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Tania Lupoli

Assistant Professor of Chemistry

    20072018
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    Fingerprint Weighted list of dominant concepts in the researcher's publications (titles and abstracts).

    Peptidoglycan Medicine & Life Sciences
    Cell Wall Medicine & Life Sciences
    Cells Chemical Compounds
    Peptidoglycan Glycosyltransferase Medicine & Life Sciences
    Penicillin-Binding Proteins Medicine & Life Sciences
    Mycobacterium tuberculosis Medicine & Life Sciences
    Peptidyl Transferases Medicine & Life Sciences
    Escherichia coli Engineering & Materials Science

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    Research Output 2007 2018

    ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB

    Yu, H., Lupoli, T., Kovach, A., Meng, X., Zhao, G., Nathan, C. F. & Li, H., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. E9560-E9569

    Research output: Contribution to journalArticle

    Mycobacterium tuberculosis
    Protein Subunits
    Hydrolysis
    Adenosine Triphosphate
    Peptides

    Targeting the Proteostasis Network for Mycobacterial Drug Discovery

    Lupoli, T., Vaubourgeix, J., Burns-Huang, K. & Gold, B., Apr 13 2018, In : ACS Infectious Diseases. 4, 4, p. 478-498 21 p.

    Research output: Contribution to journalReview article

    Drug Discovery
    Mycobacterium tuberculosis
    Immunity
    Reactive Nitrogen Species
    Proteasome Endopeptidase Complex

    Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity

    Markovski, M., Bohrhunter, J. L., Lupoli, T., Uehara, T., Walker, S., Kahne, D. E. & Bernhardt, T. G., Apr 26 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 17, p. 4788-4793 6 p.

    Research output: Contribution to journalArticle

    Peptidoglycan
    Polymerization
    Cell Wall
    Penicillin-Binding Proteins
    Membranes

    Reconstitution of a mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK

    Lupoli, T., Fay, A., Adura, C., Glickman, M. S. & Nathan, C. F., Dec 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 49, p. E7947-E7956

    Research output: Contribution to journalArticle

    Mycobacterium tuberculosis
    HSP40 Heat-Shock Proteins
    Proteins
    Small Heat-Shock Proteins
    Mycobacterium smegmatis

    Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells

    Vaubourgeix, J., Lin, G., Dhar, N., Chenouard, N., Jiang, X., Botella, H., Lupoli, T., Mariani, O., Yang, G., Ouerfelli, O., Unser, M., Schnappinger, D., McKinney, J. & Nathan, C., Feb 11 2015, In : Cell Host and Microbe. 17, 2, p. 178-190 13 p.

    Research output: Contribution to journalArticle

    Mycobacterium
    Mycobacterium tuberculosis
    Anti-Bacterial Agents
    Proteins
    Oxidants