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Tania Lupoli

Assistant Professor of Chemistry

20072018
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Fingerprint Weighted list of dominant concepts in the researcher's publications (titles and abstracts).

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Peptidoglycan Medicine & Life Sciences
Cell Wall Medicine & Life Sciences
Cells Chemical Compounds
Peptidoglycan Glycosyltransferase Medicine & Life Sciences
Penicillin-Binding Proteins Medicine & Life Sciences
Mycobacterium tuberculosis Medicine & Life Sciences
Peptidyl Transferases Medicine & Life Sciences
Escherichia coli Engineering & Materials Science

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Research Output 2007 2018

ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB

Yu, H., Lupoli, T., Kovach, A., Meng, X., Zhao, G., Nathan, C. F. & Li, H., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. E9560-E9569

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Protein Subunits
Hydrolysis
Adenosine Triphosphate
Peptides

Targeting the Proteostasis Network for Mycobacterial Drug Discovery

Lupoli, T., Vaubourgeix, J., Burns-Huang, K. & Gold, B., Apr 13 2018, In : ACS Infectious Diseases. 4, 4, p. 478-498 21 p.

Research output: Contribution to journalReview article

Drug Discovery
Mycobacterium tuberculosis
Immunity
Reactive Nitrogen Species
Proteasome Endopeptidase Complex

Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity

Markovski, M., Bohrhunter, J. L., Lupoli, T., Uehara, T., Walker, S., Kahne, D. E. & Bernhardt, T. G., Apr 26 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 17, p. 4788-4793 6 p.

Research output: Contribution to journalArticle

Peptidoglycan
Polymerization
Cell Wall
Penicillin-Binding Proteins
Membranes

Reconstitution of a mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK

Lupoli, T., Fay, A., Adura, C., Glickman, M. S. & Nathan, C. F., Dec 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 49, p. E7947-E7956

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
HSP40 Heat-Shock Proteins
Proteins
Small Heat-Shock Proteins
Mycobacterium smegmatis

Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells

Vaubourgeix, J., Lin, G., Dhar, N., Chenouard, N., Jiang, X., Botella, H., Lupoli, T., Mariani, O., Yang, G., Ouerfelli, O., Unser, M., Schnappinger, D., McKinney, J. & Nathan, C., Feb 11 2015, In : Cell Host and Microbe. 17, 2, p. 178-190 13 p.

Research output: Contribution to journalArticle

Mycobacterium
Mycobacterium tuberculosis
Anti-Bacterial Agents
Proteins
Oxidants