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Sehamuddin Galadari

Senior Vice Provost of Research Outreach, Research Professor of Biology

    1988 …2019
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    Research Output 1988 2019

    • 56 Article
    • 5 Review article
    • 2 Conference contribution
    • 2 Comment/debate
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    Article
    2019
    Phosphorylation
    Ceramides
    Prostate
    Prostatic Neoplasms
    Cells
    2018

    Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells

    Subburayan, K., Thayyullathil, F., Pallichankandy, S., Rahman, A. & Galadari, S., Jul 10 2018, In : Cancer Letters. 426, p. 80-97 18 p.

    Research output: Contribution to journalArticle

    Cell Aging
    Glioma
    Prostate
    Up-Regulation
    Apoptosis
    2016

    Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine

    Rahman, A., Thayyullathil, F., Pallichankandy, S. & Galadari, S., Jul 1 2016, In : Free Radical Biology and Medicine. 96, p. 273-289 17 p.

    Research output: Contribution to journalArticle

    Ceramides
    Hydrogen Peroxide
    Cell death
    Apoptosis
    Apoptosis Regulatory Proteins
    2015

    Effects of cannabidiol on contractions and calcium signaling in rat ventricular myocytes

    Ali, R. M., Al Kury, L. T., Yang, K. H. S., Qureshi, A., Rajesh, M., Galadari, S., Shuba, Y. M., Howarth, F. C. & Oz, M., Apr 1 2015, In : Cell Calcium. 57, 4, p. 290-299 10 p.

    Research output: Contribution to journalArticle

    Cannabidiol
    Calcium Signaling
    Muscle Cells
    Caffeine
    Isradipine

    Effects of monoterpenes on ion channels of excitable cells

    Oz, M., Lozon, Y., Sultan, A., Yang, K. H. S. & Galadari, S., Jun 29 2015, In : Pharmacology and Therapeutics. 152, p. 83-97 15 p.

    Research output: Contribution to journalArticle

    Monoterpenes
    Ion Channels
    Pharmacology
    Menthol
    Ligand-Gated Ion Channels

    ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine

    Pallichankandy, S., Rahman, A., Thayyullathil, F. & Galadari, S., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 708-720 13 p.

    Research output: Contribution to journalArticle

    Autophagy
    Glioma
    Reactive Oxygen Species
    Cell death
    Chemical activation
    2014

    Effects of endogenous cannabinoid anandamide on cardiac Na+/Ca2+ exchanger

    Kury, L. T. A., Yang, K. H. S., Thayyullathil, F. T., Rajesh, M., Ali, R. M., Shuba, Y. M., Howarth, F. C., Galadari, S. & Oz, M., Jan 1 2014, In : Cell Calcium. 55, 5, p. 231-237 7 p.

    Research output: Contribution to journalArticle

    Cannabinoids
    Muscle Cells
    Cannabinoid Receptors
    Endocannabinoids
    Pertussis Toxin

    Effects of endogenous cannabinoid anandamide on excitation-contraction coupling in rat ventricular myocytes

    Al Kury, L. T., Voitychuk, O. I., Ali, R. M., Galadari, S., Yang, K. H. S., Howarth, F. C., Shuba, Y. M. & Oz, M., Jan 1 2014, In : Cell Calcium. 55, 2, p. 104-118 15 p.

    Research output: Contribution to journalArticle

    Excitation Contraction Coupling
    Cannabinoids
    Muscle Cells
    Action Potentials
    Sarcoplasmic Reticulum

    Effects of the endogenous cannabinoid anandamide on voltage-dependent sodium and calcium channels in rat ventricular myocytes

    Al Kury, L. T., Voitychuk, O. I., Yang, K. H. S., Thayyullathil, F. T., Doroshenko, P., Ramez, A. M., Shuba, Y. M., Galadari, S., Howarth, F. C. & Oz, M., Jan 1 2014, In : British Journal of Pharmacology. 171, 14, p. 3485-3498 14 p.

    Research output: Contribution to journalArticle

    Cannabinoids
    Sodium Channels
    Calcium Channels
    Muscle Cells
    Pertussis Toxin

    ROS-dependent prostate apoptosis response-4 (Par-4) up-regulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma

    Thayyullathil, F., Rahman, A., Pallichankandy, S., Patel, M. & Galadari, S., Dec 1 2014, In : FEBS Open Bio. 4, p. 763-776 14 p.

    Research output: Contribution to journalArticle

    Curcumin
    Ceramides
    Autophagy
    Cell death
    Glioma
    2013

    Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells

    Thayyullathil, F., Pallichankandy, S., Rahman, A., Kizhakkayil, J., Chathoth, S., Patel, M. & Galadari, S., Feb 27 2013, In : Journal of Molecular Signaling. 8, 2.

    Research output: Contribution to journalArticle

    Sphingosine
    Jurkat Cells
    Caspase 3
    Prostate
    Apoptosis

    Effects of cannabidiol on the function of α7-nicotinic acetylcholine receptors

    Mahgoub, M., Keun-Hang, S. Y., Sydorenko, V., Ashoor, A., Kabbani, N., Al Kury, L., Sadek, B., Howarth, C. F., Isaev, D., Galadari, S. & Oz, M., Nov 15 2013, In : European Journal of Pharmacology. 720, 1-3, p. 310-319 10 p.

    Research output: Contribution to journalArticle

    Cannabidiol
    Nicotinic Receptors
    Oocytes
    Patch-Clamp Techniques
    Choline

    Purification and biochemical characterization of membrane-bound neutral ceramidase from camel brain (Camelus dromedarius)

    Chathoth, S., Thayyullathil, F., Galadari, A., Patel, M. & Galadari, S., Apr 16 2013, In : International Journal of Biochemistry and Molecular Biology. 4, 1, p. 54-66 13 p.

    Research output: Contribution to journalArticle

    Neutral Ceramidase
    Camelus
    Purification
    Brain
    Membranes

    Role of ceramide in diabetes mellitus: Evidence and mechanisms

    Galadari, S., Rahman, A., Pallichankandy, S., Galadari, A. & Thayyullathil, F., Jul 11 2013, In : Lipids in Health and Disease. 12, 1, 98.

    Research output: Contribution to journalArticle

    Ceramides
    Medical problems
    Diabetes Mellitus
    Insulin
    Diabetes Complications
    2012

    Curcumin induces human colon cancer cell death via p62/SQSTM1 degradation, phospho-ERK Up-regulation and ceramide generation

    Patel, M., Thayyullathil, F., Chathoth, S., Hago, A., Pallichankandy, S., Rahman, A. & Galadari, S., Dec 1 2012, In : Current Trends in Biotechnology and Pharmacy. 6, 4, p. 407-417 11 p.

    Research output: Contribution to journalArticle

    Curcumin
    Ceramides
    Colonic Neoplasms
    Cell Death
    Up-Regulation

    Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells

    Kizhakkayil, J., Thayyullathil, F., Chathoth, S., Hago, A., Patel, M. & Galadari, S., May 1 2012, In : Free Radical Biology and Medicine. 52, 9, p. 1854-1864 11 p.

    Research output: Contribution to journalArticle

    Curcumin
    Ceramides
    Caspases
    Glutathione
    Apoptosis

    Modulation of excitability, membrane currents and survival of cardiac myocytes by N-acylethanolamines

    Voitychuk, O. I., Asmolkova, V. S., Gula, N. M., Sotkis, G. V., Galadari, S., Howarth, F. C., Oz, M. & Shuba, Y. M., Sep 1 2012, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821, 9, p. 1167-1176 10 p.

    Research output: Contribution to journalArticle

    Cardiac Myocytes
    Membranes
    Patch-Clamp Techniques
    Membrane Potentials
    Muscle Cells
    2011

    Glutathione selectively inhibits Doxorubicin induced phosphorylation of p53Ser15, caspase dependent ceramide production and apoptosis in human leukemic cells

    Thayyullathil, F., Chathoth, S., Kizhakkayil, J., Galadari, A., Hago, A., Patel, M. & Galadari, S., Jul 22 2011, In : Biochemical and Biophysical Research Communications. 411, 1, p. 1-6 6 p.

    Research output: Contribution to journalArticle

    Phosphorylation
    Ceramides
    Caspases
    Doxorubicin
    Glutathione

    Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells

    Thayyullathil, F., Chathoth, S., Shahin, A., Kizhakkayil, J., Hago, A., Patel, M. & Galadari, S., Apr 1 2011, In : Journal of Cellular Biochemistry. 112, 4, p. 1138-1153 16 p.

    Research output: Contribution to journalArticle

    Protein Phosphatase 1
    Sphingosine
    Jurkat Cells
    Apoptosis
    Phosphoric Monoester Hydrolases

    Purification and characterization of a second type of neutral ceramidase from rat brain: A second more hydrophobic form of rat brain ceramidase

    Thayyullathil, F., Chathoth, S., Hago, A., Patel, M., Szulc, Z. M., Hannun, Y. & Galadari, S., Apr 1 2011, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1811, 4, p. 242-252 11 p.

    Research output: Contribution to journalArticle

    Neutral Ceramidase
    Ceramidases
    Brain
    Enzymes
    Pyrimidine Nucleotides
    2010

    Modulation of curcumin-induced Akt phosphorylation and apoptosis by PI3K inhibitor in MCF-7 cells

    Kizhakkayil, J., Thayyullathil, F., Chathoth, S., Hago, A., Patel, M. & Galadari, S., Apr 9 2010, In : Biochemical and Biophysical Research Communications. 394, 3, p. 476-481 6 p.

    Research output: Contribution to journalArticle

    Phosphorylation
    Curcumin
    MCF-7 Cells
    Phosphatidylinositol 3-Kinases
    Modulation

    The effect of δ9-tetrahydrocannabinol on 5-HT3 receptors depends on the current density

    Yang, K. H. S., Isaev, D., Morales, M., Petroianu, G., Galadari, S. & Oz, M., Nov 24 2010, In : Neuroscience. 171, 1, p. 40-49 10 p.

    Research output: Contribution to journalArticle

    Dronabinol
    Serotonin Receptors
    Complementary RNA
    Oocytes
    Serotonin

    The effects of anandamide transport inhibitor AM404 on voltage-dependent calcium channels

    Alptekin, A., Galadari, S., Shuba, Y., Petroianu, G. & Oz, M., May 1 2010, In : European Journal of Pharmacology. 634, 1-3, p. 10-15 6 p.

    Research output: Contribution to journalArticle

    Calcium Channels
    Isradipine
    Skeletal Muscle Fibers
    Skeletal Muscle
    Membranes

    The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism

    Oz, M., Jaligam, V., Galadari, S., Petroianu, G., Shuba, Y. M. & Shippenberg, T. S., Mar 1 2010, In : Journal of Neurochemistry. 112, 6, p. 1454-1464 11 p.

    Research output: Contribution to journalArticle

    Dopamine Plasma Membrane Transport Proteins
    Cannabinoids
    Amidohydrolases
    Phenylmethylsulfonyl Fluoride
    Biotinylation

    The nonpsychoactive cannabinoid cannabidiol inhibits 5- hydroxytryptamine3A receptor-mediated currents in xenopus laevis oocytes

    Yang, K. H., Galadari, S., Isaev, D., Petroianu, G., Shippenberg, T. S. & Oz, M., May 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 333, 2, p. 547-554 8 p.

    Research output: Contribution to journalArticle

    Cannabidiol
    Cannabinoids
    Xenopus laevis
    Oocytes
    Receptors, Serotonin, 5-HT3
    2009

    Alkaline ceramidase 2 regulates beta;1 integrin maturation and cell adhesion

    Sun, W., Hu, W., Xu, R., Jin, J., Szulc, Z. M., Zhang, G., Galadari, S., Obeid, L. M. & Mao, C., Feb 1 2009, In : FASEB Journal. 23, 2, p. 656-666 11 p.

    Research output: Contribution to journalArticle

    Alkaline Ceramidase
    Cell adhesion
    Cell Adhesion
    Integrins
    Sphingosine

    UVC-induced apoptosis in Dubca cells is independent of JNK activation and p53Ser-15 phosphorylation

    Chathoth, S., Thayyullathil, F., Hago, A., Shahin, A., Patel, M. & Galadari, S., Jun 12 2009, In : Biochemical and Biophysical Research Communications. 383, 4, p. 426-432 7 p.

    Research output: Contribution to journalArticle

    Phosphorylation
    Phosphotransferases
    Chemical activation
    Apoptosis
    Activating Transcription Factor 2
    2008

    Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7

    Michael Conlon, J., Galadari, S., Raza, H. & Condamine, E., Jul 1 2008, In : Chemical Biology and Drug Design. 72, 1, p. 58-64 7 p.

    Research output: Contribution to journalArticle

    Anti-Infective Agents
    Anura
    Skin
    Substitution reactions
    Candida albicans

    Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells

    Thayyullathil, F., Chathoth, S., Hago, A., Patel, M. & Galadari, S., Nov 15 2008, In : Free Radical Biology and Medicine. 45, 10, p. 1403-1412 10 p.

    Research output: Contribution to journalArticle

    Curcumin
    Caspases
    Reactive Oxygen Species
    Apoptosis
    Apoptosis Inducing Factor
    2007

    Effect of aminoisobutyric acid (Aib) substitutions on the antimicrobial and cytolytic activities of the frog skin peptide, temporin-1DRa

    Michael Conlon, J., Al-Kharrge, R., Ahmed, E., Raza, H., Galadari, S. & Condamine, E., Oct 1 2007, In : Peptides. 28, 10, p. 2075-2080 6 p.

    Research output: Contribution to journalArticle

    Aminoisobutyric Acids
    Anura
    Skin
    Substitution reactions
    Hydrophobicity
    2006

    Contact dermatitis in UAE

    Galadari, I., Galadari, S. & Al Saaie, L., Jun 1 2006, In : European Annals of Allergy and Clinical Immunology. 38, 6, p. 195-197 3 p.

    Research output: Contribution to journalArticle

    Contact Dermatitis
    Hand
    Eczema
    Dermatology
    Parabens

    Identification of a novel amidase motif in neutral ceramidase

    Galadari, S., Wu, B. X., Mao, C., Roddy, P., El Bawab, S. & Hannun, Y. A., Feb 1 2006, In : Biochemical Journal. 393, 3, p. 687-695 9 p.

    Research output: Contribution to journalArticle

    amidase
    Neutral Ceramidase
    Serine
    Conserved Sequence
    fluorophosphate
    Oxidative stress
    Protein S
    Fibroblasts
    Glutathione
    Skin
    2005

    Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives

    Conlon, J. M., Abraham, B., Galadari, S., Knoop, F. C., Sonnevend, A. & Pál, T., Nov 1 2005, In : Peptides. 26, 11, p. 2104-2110 7 p.

    Research output: Contribution to journalArticle

    Anura
    Lysine
    Skin
    Derivatives
    Peptides

    Design of potent, non-toxic antimicrobial agents based upon the structure of the frog skin peptide, pseudin-2

    Pál, T., Sonnevend, Á., Galadari, S. & Conlon, J. M., Jul 15 2005, In : Regulatory Peptides. 129, 1-3, p. 85-91 7 p.

    Research output: Contribution to journalArticle

    Anti-Infective Agents
    Anura
    Lysine
    Neutral Amino Acids
    Skin

    Streptozotocin-induced diabetic nephropathy in rats: The role of inflammatory cytokines

    Mensah-Brown, E. P. K., Obineche, E. N., Galadari, S., Chandranath, E., Shahin, A., Ahmed, I., Patel, S. M. & Adem, A., Aug 7 2005, In : Cytokine. 31, 3, p. 180-190 11 p.

    Research output: Contribution to journalArticle

    T-cells
    Diabetic Nephropathies
    Streptozocin
    Rats
    Cytokines
    2003

    Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase. An enzyme that preferentially regulates metabolism of very long chain ceramides

    Mao, C., Xu, R., Szulc, Z. M., Bielawski, J., Beeker, K. P., Bielawska, A., Galadari, S., Hu, W. & Obeid, L. M., Aug 15 2003, In : Journal of Biological Chemistry. 278, 33, p. 31184-31191 8 p.

    Research output: Contribution to journalArticle

    Alkaline Ceramidase
    Ceramides
    Cloning
    Metabolism
    Endoplasmic Reticulum
    2001

    Cloning and characterization of a novel human alkaline ceramidase: A mammalian enzyme that hydrolyzes phytoceramide

    Mao, C., Xu, R., Szulc, Z. M., Bielawska, A., Galadari, S. & Obeid, L. M., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26577-26588 12 p.

    Research output: Contribution to journalArticle

    Alkaline Ceramidase
    Ceramidases
    Cloning
    Yeast
    Organism Cloning

    Effects of cations on ceramide-activated protein phosphatase 2A

    Galadari, S., Hago, A. & Patel, M., Dec 31 2001, In : Experimental and Molecular Medicine. 33, 4, p. 240-244 5 p.

    Research output: Contribution to journalArticle

    Protein Phosphatase 2
    Ceramides
    Cations
    Phosphoric Monoester Hydrolases
    Metals

    FAS Activation Induces Dephosphorylation of SR Proteins: Dependence on the de novo generation of ceramide and activation of protein phosphatase 1

    Chalfant, C. E., Ogretmen, B., Galadari, S., Kroesen, B. J., Pettus, B. J. & Hannun, Y. A., Nov 30 2001, In : Journal of Biological Chemistry. 276, 48, p. 44848-44855 8 p.

    Research output: Contribution to journalArticle

    Protein Phosphatase 1
    Ceramides
    Serine
    Arginine
    Chemical activation

    Fasting during the holy month of Ramadan does not change the composition of breast milk

    Bener, A., Galadari, S., Gillett, M., Osman, N., Al-Taneiji, H., Al-Kuwaiti, M. H. H. & Al-Sabosy, M. M. A., Jun 21 2001, In : Nutrition Research. 21, 6, p. 859-864 6 p.

    Research output: Contribution to journalArticle

    Human Milk
    Fasting
    Mothers
    Primary Health Care
    Triglycerides

    Lack of apoptosis of infiltrating cells as the mechanism of high susceptibility to EAE in DA rats

    Lukic, M. L., Mensah-Brown, E., Galadari, S. & Shahin, A., Dec 1 2001, In : Developmental Immunology. 8, 3-4, p. 193-200 8 p.

    Research output: Contribution to journalArticle

    Autoimmune Experimental Encephalomyelitis
    Apoptosis
    Interferons
    Cell Count
    Lymph Nodes

    Longer breast-feeding and protection against childhood leukaemia and lymphomas

    Bener, A., Denic, S. & Galadari, S., Feb 21 2001, In : European Journal of Cancer. 37, 2, p. 234-238 5 p.

    Research output: Contribution to journalArticle

    Breast Feeding
    Lymphoma
    Leukemia
    Odds Ratio
    Confidence Intervals

    The Src-protein tyrosine kinase Lck is required for IL-1-mediated costimulatory signaling in Th2 cells

    Al-Ramadi, B. K., Welte, T., Fernandez-Cabezudo, M. J., Galadari, S., Dittel, B., Fu, X. Y. & Bothwell, A. L. M., Dec 15 2001, In : Journal of Immunology. 167, 12, p. 6827-6833 7 p.

    Research output: Contribution to journalArticle

    Th2 Cells
    src-Family Kinases
    Interleukin-1
    Tyrosine
    Phosphorylation
    2000

    Proteolytic cleavage of phospholipase C-γ1 during apoptosis in Molt-4 cells

    Bae, S. S., Perry, D. K., Oh, Y. S., Choi, J. H., Galadari, S., Ghayur, T., Ryu, S. H., Hannun, Y. A. & Suh, P. G., Jun 24 2000, In : FASEB Journal. 14, 9, p. 1083-1092 10 p.

    Research output: Contribution to journalArticle

    Type C Phospholipases
    Apoptosis
    Tyrosine
    Etoposide
    Phosphorylation

    Proto-oncogene ras GTPase-linked induction of glutathione-S-transferase by growth factors in PC12 cells.

    Nur-E-Kamal, M. S., Qureshi, M. M., Ijaz, M. K., Galadari, S. & Raza, H., May 1 2000, In : International Journal of Oncology. 16, 5, p. 1043-1048 6 p.

    Research output: Contribution to journalArticle

    ras Proteins
    Proto-Oncogenes
    PC12 Cells
    Glutathione Transferase
    Intercellular Signaling Peptides and Proteins
    1998

    A rapid method for the identification of ceramide activated protein phosphatase

    Galadari, S. & Kishikawa, K., Dec 1 1998, In : FASEB Journal. 12, 8

    Research output: Contribution to journalArticle

    Ceramides
    Phosphoprotein Phosphatases
    Sphingomyelins
    Hydrophobic chromatography
    Chemical activation

    Purification and characterization of ceramide-activated protein phosphatases

    Galadari, S., Kishikawa, K., Kamibayashi, C., Mumby, M. C. & Hannun, Y. A., Aug 11 1998, In : Biochemistry. 37, 32, p. 11232-11238 7 p.

    Research output: Contribution to journalArticle

    Ceramides
    Phosphoprotein Phosphatases
    Purification
    Chromatography
    Size exclusion chromatography

    Src homology domains of phospholipase C γ1 inhibit nerve growth factor- induced differentiation of PC12 cells

    Bae, S. S., Lee, Y. H., Chang, J. S., Galadari, S., Kim, Y. S., Ryu, S. H. & Suh, P. G., Jul 1 1998, In : Journal of Neurochemistry. 71, 1, p. 178-185 8 p.

    Research output: Contribution to journalArticle

    Growth Differentiation Factors
    src Homology Domains
    PC12 Cells
    Type C Phospholipases
    Nerve Growth Factor
    1997

    Characterization of ceramide activated protein phosphatase: effect of cations

    Galadari, S. & Ifann, Y. A., Dec 1 1997, In : FASEB Journal. 11, 9

    Research output: Contribution to journalArticle

    Ceramides
    Phosphoprotein Phosphatases
    Cations
    Phosphoric Monoester Hydrolases
    Metals