No photo of Rebecca Betensky

Rebecca Betensky

Professor

    1987 …2019
    If you made any changes in Pure, your changes will be visible here soon.

    Research Output 1987 2019

    2019

    Association of Amyloid and Tau with Cognition in Preclinical Alzheimer Disease: A Longitudinal Study

    Hanseeuw, B. J., Betensky, R., Jacobs, H. I. L., Schultz, A. P., Sepulcre, J., Becker, J. A., Cosio, D. M. O., Farrell, M., Quiroz, Y. T., Mormino, E. C., Buckley, R. F., Papp, K. V., Amariglio, R. A., Dewachter, I., Ivanoiu, A., Huijbers, W., Hedden, T., Marshall, G. A., Chhatwal, J. P., Rentz, D. M. & 2 others, Sperling, R. A. & Johnson, K., Jan 1 2019, In : JAMA Neurology.

    Research output: Contribution to journalArticle

    Amyloid
    Positron-Emission Tomography
    Cognition
    Longitudinal Studies
    Alzheimer Disease

    Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanisms

    Lin, Y. F., Smith, A. V., Aspelund, T., Betensky, R., Smoller, J. W., Gudnason, V., Launer, L. J. & Blacker, D., Jan 1 2019, In : Alzheimer's and Dementia. 15, 1, p. 65-75 11 p.

    Research output: Contribution to journalArticle

    Vascular Dementia
    Alzheimer Disease
    Pathology
    Cognition
    Blood Vessels

    Inverse probability weighting methods for Cox regression with right-truncated data

    Vakulenko-Lagun, B., Mandel, M. & Betensky, R. A., Jan 1 2019, (Accepted/In press) In : Biometrics.

    Research output: Contribution to journalArticle

    Inverse Probability Weighting
    Cox Regression
    Truncated Data
    Estimating Equation
    Positivity

    New guidelines for statistical reporting

    Betensky, R. A. & Newberger, N. G., Oct 17 2019, In : New England Journal of Medicine. 381, 16, 1 p.

    Research output: Contribution to journalLetter

    Statistical Data Interpretation
    Vitamin D
    Research Design
    Cardiovascular Diseases
    Guidelines

    Nonidentifiability in the presence of factorization for truncated data.

    Vakulenko-Lagun, B., Qian, J., Chiou, S. H. & Betensky, R. A., Sep 1 2019, In : Biometrika. 106, 3, p. 724-731 8 p.

    Research output: Contribution to journalArticle

    Open Access
    Truncated Data
    Risk Adjustment
    Factorization
    Quasi-independence
    Adjustment

    Publisher Correction: Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI (Scientific Reports, (2018), 8, 1, (17062), 10.1038/s41598-018-34820-x)

    Ly, K. I., Vakulenko-Lagun, B., Emblem, K. E., Ou, Y., Da, X., Betensky, R., Kalpathy-Cramer, J., Duda, D. G., Jain, R. K., Chi, A. S., Plotkin, S. R., Batchelor, T. T., Sorensen, G., Rosen, B. R. & Gerstner, E. R., Dec 1 2019, In : Scientific reports. 9, 1, 8721.

    Research output: Contribution to journalComment/debate

    Open Access
    temozolomide
    Tumor Microenvironment
    Glioblastoma
    Magnetic Resonance Imaging
    indium arsenide

    Serum levels of 25-hydroxyvitamin D at diagnosis are not associated with overall survival in esophageal adenocarcinoma

    Loehrer, E., Betensky, R., Giovannucci, E., Su, L., Shafer, A., Hollis, B. W. & Christiani, D. C., Jan 1 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 8, p. 1379-1387 9 p.

    Research output: Contribution to journalArticle

    Adenocarcinoma
    Survival
    Serum
    Confidence Intervals
    Neoplasms

    The impact of amyloid-beta and tau on prospective cognitive decline in older individuals

    Sperling, R. A., Mormino, E. C., Schultz, A. P., Betensky, R., Papp, K. V., Amariglio, R. E., Hanseeuw, B. J., Buckley, R., Chhatwal, J., Hedden, T., Marshall, G. A., Quiroz, Y. T., Donovan, N. J., Jackson, J., Gatchel, J. R., Rabin, J. S., Jacobs, H., Yang, H. S., Properzi, M., Kirn, D. R. & 2 others, Rentz, D. M. & Johnson, K. A., Feb 1 2019, In : Annals of Neurology. 85, 2, p. 181-193 13 p.

    Research output: Contribution to journalArticle

    Amyloid
    Alzheimer Disease
    Positron-Emission Tomography
    Executive Function
    Pathology

    The missing indicator approach for censored covariates subject to limit of detection in logistic regression models

    Chiou, S. H., Betensky, R. & Balasubramanian, R., Oct 2019, In : Annals of Epidemiology. 38, p. 57-64 8 p.

    Research output: Contribution to journalArticle

    Limit of Detection
    Case-Control Studies
    Logistic Models
    Metabolome
    Sample Size

    The p-Value Requires Context, Not a Threshold

    Betensky, R., Mar 29 2019, In : American Statistician. 73, sup1, p. 115-117 3 p.

    Research output: Contribution to journalArticle

    Open Access
    p-Value
    Effect Size
    Sample Size
    Confidence Bounds
    Null hypothesis
    2018

    An optimal Wilcoxon–Mann–Whitney test of mortality and a continuous outcome

    Matsouaka, R. A., Singhal, A. B. & Betensky, R., Aug 1 2018, In : Statistical Methods in Medical Research. 27, 8, p. 2384-2400 17 p.

    Research output: Contribution to journalArticle

    Optimal Test
    Mortality
    Test Statistic
    Randomized Clinical Trial
    Stroke

    Association of anxiety with subcortical amyloidosis in cognitively normal older adults

    Hanseeuw, B. J., Jonas, V., Jackson, J., Betensky, R., Rentz, D. M., Johnson, K. A., Sperling, R. A. & Donovan, N. J., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

    Amyloidosis
    Anxiety
    Amyloid
    Alzheimer Disease
    Positron-Emission Tomography

    Biomarker validation with an imperfect reference: Issues and bounds

    Emerson, S. C., Waikar, S. S., Fuentes, C., Bonventre, J. V. & Betensky, R., Oct 1 2018, In : Statistical Methods in Medical Research. 27, 10, p. 2933-2945 13 p.

    Research output: Contribution to journalArticle

    Biomarkers
    Imperfect
    Conditional Independence
    Operating Characteristics
    Latent Class Analysis

    Correction to: Association of anxiety with subcortical amyloidosis in cognitively normal older adults (Molecular Psychiatry, (2018), 10.1038/s41380-018-0214-2)

    Hanseeuw, B. J., Jonas, V., Jackson, J., Betensky, R., Rentz, D. M., Johnson, K. A., Sperling, R. A. & Donovan, N. J., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

    Amyloidosis
    Licensure
    Psychiatry
    Anxiety

    Design and analysis considerations for combining data from multiple biomarker studies

    Sloan, A., Song, Y., Gail, M. H., Betensky, R., Rosner, B., Ziegler, R. G., Smith-Warner, S. A. & Wang, M., Jan 1 2018, (Accepted/In press) In : Statistics in Medicine.

    Research output: Contribution to journalArticle

    Biomarkers
    Calibration
    Pooling
    Cohort Study
    Design

    Hypothesis Tests for Neyman's Bias in Case–Control Studies

    Swanson, D. M., Anderson, C. D. & Betensky, R., Aug 18 2018, In : Journal of Applied Statistics. 45, 11, p. 1956-1977 22 p.

    Research output: Contribution to journalArticle

    Case-control Study
    Hypothesis Test
    Mortality
    Atrial Fibrillation
    Brain Tumor

    Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response

    Plant, A. S., Koyama, S., Sinai, C., Solomon, I. H., Griffin, G. K., Ligon, K. L., Bandopadhayay, P., Betensky, R., Emerson, R., Dranoff, G., Kieran, M. W. & Ritz, J., Apr 1 2018, In : Journal of Neuro-Oncology. 137, 2, p. 269-278 10 p.

    Research output: Contribution to journalArticle

    Immunophenotyping
    Brain Neoplasms
    Histology
    Pediatrics
    T-Lymphocytes

    Integration of risk factors for Parkinson disease in 2 large longitudinal cohorts

    Kim, I. Y., O'Reilly, É. J., Hughes, K. C., Gao, X., Schwarzschild, M. A., Hannan, M. T., Betensky, R. & Ascherio, A., May 8 2018, In : Neurology. 90, 19, p. e1646-e1653

    Research output: Contribution to journalArticle

    Parkinson Disease
    Caffeine
    Health
    Nurses
    Confidence Intervals

    Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk

    Kim, I. Y., O'Reilly, É. J., Hughes, K. C., Gao, X., Schwarzschild, M. A., McCullough, M. L., Hannan, M. T., Betensky, R. & Ascherio, A., Mar 1 2018, In : Movement Disorders. 33, 3, p. 414-420 7 p.

    Research output: Contribution to journalArticle

    Ionotropic Glutamate Receptors
    Cytochrome P-450 CYP1A2
    Caffeine
    Parkinson Disease
    Confidence Intervals

    Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results

    on behalf of the MR WITNESS Investigators, May 1 2018, In : Annals of Neurology. 83, 5, p. 980-993 14 p.

    Research output: Contribution to journalArticle

    Stroke
    Intracranial Hemorrhages
    Tissue Plasminogen Activator
    Diffusion Magnetic Resonance Imaging
    Brain Edema

    Inverse probability weighted Cox regression for doubly truncated data

    Mandel, M., de Uña-Álvarez, J., Simon, D. K. & Betensky, R., Jun 1 2018, In : Biometrics. 74, 2, p. 481-487 7 p.

    Research output: Contribution to journalArticle

    Cox Regression
    Truncated Data
    Covariates
    Nucleotides
    Polymorphism

    Multicrossover Randomized Controlled Trial Designs in Alzheimer Disease

    Arnold, S. E. & Betensky, R., Aug 1 2018, In : Annals of Neurology. 84, 2, p. 168-175 8 p.

    Research output: Contribution to journalArticle

    Alzheimer Disease
    Randomized Controlled Trials

    Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain

    Hopp, S. C., Bihlmeyer, N. A., Corradi, J. P., Vanderburg, C., Cacace, A. M., Das, S., Clark, T. W., Betensky, R., Hyman, B. T. & Hudry, E., Oct 1 2018, In : Journal of Neurochemistry. 147, 1, p. 24-39 16 p.

    Research output: Contribution to journalArticle

    Calcineurin
    Brain
    Alzheimer Disease
    Chemical activation
    MicroRNAs

    Permutation tests for general dependent truncation

    Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging & Harvard Aging Brain Study, Dec 1 2018, In : Computational Statistics and Data Analysis. 128, p. 308-324 17 p.

    Research output: Contribution to journalArticle

    Quasi-independence
    Permutation Test
    Truncation
    Dependent
    Factorization

    PET staging of amyloidosis using striatum

    Alzheimer's Disease Neuroimaging Initiative & Harvard Aging Brain Study, Oct 1 2018, In : Alzheimer's and Dementia. 14, 10, p. 1281-1292 12 p.

    Research output: Contribution to journalArticle

    Amyloidosis
    Positron-Emission Tomography
    Amyloid
    Corpus Striatum
    Cognition

    Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms

    Lin, Y. F., Chen, C. Y., Öngür, D., Betensky, R., Smoller, J. W., Blacker, D. & Hall, M. H., Dec 1 2018, In : Translational Psychiatry. 8, 1, 97.

    Research output: Contribution to journalArticle

    Evoked Potentials
    Psychotic Disorders
    Aptitude
    Genome-Wide Association Study
    Intelligence

    Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI

    Ina Ly, K., Vakulenko-Lagun, B., Emblem, K. E., Ou, Y., Da, X., Betensky, R., Kalpathy-Cramer, J., Duda, D. G., Jain, R. K., Chi, A. S., Plotkin, S. R., Batchelor, T. T., Sorensen, G., Rosen, B. R. & Gerstner, E. R., Dec 1 2018, In : Scientific Reports. 8, 1, 17062.

    Research output: Contribution to journalArticle

    temozolomide
    Cerebrovascular Circulation
    Tumor Microenvironment
    Glioblastoma
    Magnetic Resonance Imaging

    rBPI21 (opebacan) promotes rapid trilineage hematopoietic recovery in a murine model of high-dose total body irradiation

    Janec, K. J., Yuan, H., Norton, J. E., Kelner, R. H., Hirt, C. K., Betensky, R. & Guinan, E. C., Aug 1 2018, In : American Journal of Hematology. 93, 8, p. 1002-1013 12 p.

    Research output: Contribution to journalArticle

    Whole-Body Irradiation
    Radiation
    Bone Marrow
    Megakaryocytes
    Resource Allocation

    Reader response: Systematic review and statistical analysis of the integrity of 33 randomized controlled trials

    Betensky, R. & Chiou, S. H., Mar 20 2018, In : Neurology. 90, 12, 1 p.

    Research output: Contribution to journalLetter

    Randomized Controlled Trials

    Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease

    Bennett, R. E., Robbins, A. B., Hu, M., Cao, X., Betensky, R., Clark, T., Das, S. & Hyman, B. T., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. E1289-E1298

    Research output: Contribution to journalArticle

    Transgenic Mice
    Blood Vessels
    Alzheimer Disease
    Gene Expression
    Pathology

    The prognostic value of histopathologic lesions in native kidney biopsy specimens: Results from the Boston kidney biopsy cohort study

    Srivastava, A., Palsson, R., Kaze, A. D., Chen, M. E., Palacios, P., Sabbisetti, V., Betensky, R., Steinman, T. I., Thadhani, R. I., McMahon, G. M., Stillman, I. E., Rennke, H. G. & Waikar, S. S., Aug 1 2018, In : Journal of the American Society of Nephrology. 29, 8, p. 2213-2224 12 p.

    Research output: Contribution to journalArticle

    Kidney Diseases
    Cohort Studies
    Kidney
    Biopsy
    Disease Progression

    Threshold regression to accommodate a censored covariate

    Qian, J., Chiou, S. H., Maye, J. E., Atem, F., Johnson, K. A. & Betensky, R., Dec 1 2018, In : Biometrics. 74, 4, p. 1261-1270 10 p.

    Research output: Contribution to journalArticle

    Covariates
    dementia
    Regression
    amyloid
    Alzheimer disease

    Time-to-event data with time-varying biomarkers measured only at study entry, with applications to Alzheimer's disease

    for the Alzheimer's Disease Neuroimaging Initiative, Mar 15 2018, In : Statistics in Medicine. 37, 6, p. 914-932 19 p.

    Research output: Contribution to journalArticle

    Time-varying Covariates
    Alzheimer's Disease
    Biomarkers
    Time-varying
    Alzheimer Disease

    Transformation model estimation of survival under dependent truncation and independent censoring

    Chiou, S. H., Austin, M. D., Qian, J. & Betensky, R., Jan 1 2018, (Accepted/In press) In : Statistical Methods in Medical Research.

    Research output: Contribution to journalArticle

    Transformation Model
    Quasi-independence
    Censoring
    Truncation
    Right Censoring

    Wide Range of Clinical Outcomes in Patients with Gliomatosis Cerebri Growth Pattern: A Clinical, Radiographic, and Histopathologic Study

    Ly, K. I., Oakley, D. H., Pine, A. B., Frosch, M. P., Chiou, S. H., Betensky, R., Pomerantz, S. R., Hochberg, F. H., Batchelor, T. T., Cahill, D. P. & Dietrich, J., Jan 1 2018, (Accepted/In press) In : Oncologist.

    Research output: Contribution to journalArticle

    Neuroepithelial Neoplasms
    Growth
    Survival
    Magnetic Resonance Imaging
    Confidence Intervals
    2017

    APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts

    Qian, J., Wolters, F. J., Beiser, A., Haan, M., Ikram, M. A., Karlawish, J., Langbaum, J. B., Neuhaus, J. M., Reiman, E. M., Roberts, J. S., Seshadri, S., Tariot, P. N., Woods, B. M. C., Betensky, R. & Blacker, D., Mar 1 2017, In : PLoS Medicine. 14, 3, e1002254.

    Research output: Contribution to journalArticle

    Dementia
    Cohort Studies
    Incidence
    Genotype
    Genetic Phenomena

    Association of cancer and Alzheimer's disease risk in a national cohort of veterans

    Frain, L., Swanson, D., Cho, K., Gagnon, D., Lu, K. P., Betensky, R. & Driver, J., Dec 1 2017, In : Alzheimer's and Dementia. 13, 12, p. 1364-1370 7 p.

    Research output: Contribution to journalArticle

    Veterans
    Alzheimer Disease
    Neoplasms
    Survivors
    Prostatic Neoplasms

    Bayesian Variable Selection Methods for Matched Case-Control Studies

    Asafu-Adjei, J., Mahlet, G. T., Coull, B., Balasubramanian, R., Lev, M., Schwamm, L. & Betensky, R., Jan 1 2017, In : International Journal of Biostatistics. 13, 1, 20160043.

    Research output: Contribution to journalArticle

    Matched Case-control Study
    Bayesian Variable Selection
    Variable Selection
    Case-control
    Statistical Power

    Cognitive resilience in clinical and preclinical Alzheimer’s disease: the Association of Amyloid and Tau Burden on cognitive performance

    Rentz, D. M., Mormino, E. C., Papp, K. V., Betensky, R., Sperling, R. A. & Johnson, K. A., Apr 1 2017, In : Brain Imaging and Behavior. 11, 2, p. 383-390 8 p.

    Research output: Contribution to journalArticle

    Cognitive Reserve
    Amyloid
    Alzheimer Disease
    Linear Models
    Proxy

    Correlation among baseline variables yields non-uniformity of p-values

    Betensky, R. & Chiou, S. H., Sep 1 2017, In : PLoS One. 12, 9, e0184531.

    Research output: Contribution to journalArticle

    Statistical tests
    Neurology
    Random Allocation
    Testing
    clinical trials

    Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline

    Hanseeuw, B. J., Betensky, R., Schultz, A. P., Papp, K. V., Mormino, E. C., Sepulcre, J., Bark, J. S., Cosio, D. M., LaPoint, M., Chhatwal, J. P., Rentz, D. M., Sperling, R. A. & Johnson, K. A., Apr 1 2017, In : Annals of Neurology. 81, 4, p. 583-596 14 p.

    Research output: Contribution to journalArticle

    Amyloid
    Tauopathies
    Alzheimer Disease
    Glucose
    Entorhinal Cortex

    Is this significant?

    Betensky, R., Mar 1 2017, In : Annals of Neurology. 81, 3, p. 344-347 4 p.

    Research output: Contribution to journalEditorial

    Linear regression with a randomly censored covariate: application to an Alzheimer's study

    Atem, F. D., Qian, J., Maye, J. E., Johnson, K. A. & Betensky, R., Feb 1 2017, In : Journal of the Royal Statistical Society. Series C: Applied Statistics. 66, 2, p. 313-328 16 p.

    Research output: Contribution to journalArticle

    Linear regression
    Covariates
    Random Censoring
    Dementia
    Imputation
    Neurofibrillary Tangles
    Autopsy
    Clinical Trials
    Dementia
    Alzheimer Disease

    Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

    Arbel-Ornath, M., Hudry, E., Boivin, J. R., Hashimoto, T., Takeda, S., Kuchibhotla, K. V., Hou, S., Lattarulo, C. R., Belcher, A. M., Shakerdge, N., Trujillo, P. B., Muzikansky, A., Betensky, R., Hyman, B. T. & Bacskai, B. J., Mar 21 2017, In : Molecular Neurodegeneration. 12, 1, 27.

    Research output: Contribution to journalArticle

    Amyloid
    Synapses
    Calcium
    Brain
    Alzheimer Disease
    2016

    A concept-wide association study of clinical notes to discover new predictors of kidney failure

    Singh, K., Betensky, R., Wright, A., Curhan, G. C., Bates, D. W. & Waikar, S. S., Jan 1 2016, In : Clinical Journal of the American Society of Nephrology. 11, 12, p. 2150-2158 9 p.

    Research output: Contribution to journalArticle

    Chronic Kidney Failure
    Renal Insufficiency
    Nephrology
    Confidence Intervals
    Fast Foods

    Comparison of urine output among patients treated with more intensive versus less intensive RRT: Results from the acute renal failure trial network study

    McCausland, F. R., Asafu-Adjei, J., Betensky, R., Palevsky, P. M. & Waikar, S. S., Jan 1 2016, In : Clinical Journal of the American Society of Nephrology. 11, 8, p. 1335-1342 8 p.

    Research output: Contribution to journalArticle

    Acute Kidney Injury
    Urine
    Critical Illness
    Hemodiafiltration
    Renal Dialysis

    Decreased hippocampal metabolism in high-amyloid mild cognitive impairment

    Hanseeuw, B. J., Schultz, A. P., Betensky, R., Sperling, R. A. & Johnson, K. A., Dec 1 2016, In : Alzheimer's and Dementia. 12, 12, p. 1288-1296 9 p.

    Research output: Contribution to journalArticle

    Amyloid
    Positron-Emission Tomography
    Cognitive Dysfunction
    Atrophy
    Linear Models

    Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly

    Dhilla Albers, A., Asafu-Adjei, J., Delaney, M. K., Kelly, K. E., Gomez-Isla, T., Blacker, D., Johnson, K. A., Sperling, R. A., Hyman, B. T., Betensky, R., Hastings, L. & Albers, M. W., Dec 1 2016, In : Annals of Neurology. 80, 6, p. 846-857 12 p.

    Research output: Contribution to journalArticle

    Episodic Memory
    Biomarkers
    Alzheimer Disease
    Odorants
    Entorhinal Cortex

    Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring

    Maye, J. E., Betensky, R., Gidicsin, C. M., Locascio, J., Becker, J. A., Pepin, L., Carmasin, J., Rentz, D. M., Marshall, G. A., Blacker, D., Sperling, R. A. & Johnson, K. A., Apr 1 2016, In : Neurobiology of Aging. 40, p. 61-67 7 p.

    Research output: Contribution to journalArticle

    Maternal Age
    Age of Onset
    Amyloid
    Dementia
    Mothers