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Piergiorgio Percipalle

Associate Professor, Biology

    19942019
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    Research Output 1994 2019

    2019
    Open Access
    Gene Expression Profiling
    Fibroblasts
    Antiviral Agents
    Genes
    Immunity

    Cytoskeletal proteins in the cell nucleus: A special nuclear actin perspective

    Percipalle, P. & Vartiainen, M., Jul 15 2019, In : Molecular Biology of the Cell. 30, 15, p. 1781-1785 5 p.

    Research output: Contribution to journalReview article

    Open Access
    Cytoskeletal Proteins
    Cell Nucleus
    Actins
    Nuclear Lamina
    Genome

    Mitochondria-localized β-actin is essential for priming innate antiviral immune signaling by regulating IRF3 protein stability

    Xie, X., Endara-Coll, M., Mahmood, R., Jankauskas, R., Gjorgjieva, T. & Percipalle, P., Jan 1 2019, (Accepted/In press) In : Cellular and Molecular Immunology.

    Research output: Contribution to journalLetter

    Protein Stability
    Antiviral Agents
    Actins
    Mitochondria

    Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

    Prakash, V., Carson, B. B., Feenstra, J. M., Dass, R. A., Sekyrova, P., Hoshino, A., Petersen, J., Guo, Y., Parks, M. M., Kurylo, C. M., Batchelder, J. E., Haller, K., Hashimoto, A., Rundqivst, H., Condeelis, J. S., Allis, C. D., Drygin, D., Nieto, M. A., Andäng, M., Percipalle, P. & 8 others, Bergh, J., Adameyko, I., Farrants, A. K. Ö., Hartman, J., Lyden, D., Pietras, K., Blanchard, S. C. & Vincent, C. T., Dec 1 2019, In : Nature Communications. 10, 1, 2110.

    Research output: Contribution to journalArticle

    Open Access
    biological evolution
    ribosomes
    Epithelial-Mesenchymal Transition
    Cell Cycle Checkpoints
    Ribosomes
    2018
    Myofibroblasts
    Transforming Growth Factors
    Fibroblasts
    Knockout Mice
    Actins

    In Mitochondria β-Actin Regulates mtDNA Transcription and Is Required for Mitochondrial Quality Control

    Xie, X., Venit, T., Drou, N. & Percipalle, P., May 25 2018, In : Food Science and Human Wellness. 3, p. 226-237 12 p.

    Research output: Contribution to journalArticle

    Open Access
    Mitochondrial DNA
    Quality Control
    actin
    quality control
    Actins

    The relative composition of actin isoforms regulates cell surface biophysical features and cellular behaviors

    Xie, X., Deliorman, M., Qasaimeh, M. & Percipalle, P., May 1 2018, In : Biochimica et Biophysica Acta - General Subjects. 1862, 5, p. 1079-1090 12 p.

    Research output: Contribution to journalArticle

    Actins
    Protein Isoforms
    Chemical analysis
    Surface Properties
    Mammals

    β-Actin-dependent global chromatin organization and gene expression programs control cellular identity

    Xie, X., Almuzzaini, B., Drou, N., Kremb, S., Yousif, A., Farrants, A. K. Ö., Gunsalus, K. & Percipalle, P., Mar 1 2018, In : FASEB Journal. 32, 3, p. 1296-1314 19 p.

    Research output: Contribution to journalArticle

    Gene expression
    Chromatin
    Actins
    Genes
    Gene Expression

    β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming

    Xie, X., Jankauskas, R., Mazari, A. M. A., Drou, N. & Percipalle, P., Dec 1 2018, In : PLoS Genetics. 14, 12, e1007846.

    Research output: Contribution to journalArticle

    Heterochromatin
    heterochromatin
    actin
    Actins
    gene
    2017

    An actin-based nucleoskeleton involved in gene regulation and genome organization

    Xie, X. & Percipalle, P., Jan 1 2017, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

    Research output: Contribution to journalArticle

    Nuclear Matrix
    Gene expression
    Actins
    Genes
    Genome

    Nuclear Wiskott-Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells

    Kuznetsov, N. V., Almuzzaini, B., Kritikou, J. S., Baptista, M. A. P., Oliveira, M. M. S., Keszei, M., Snapper, S. B., Percipalle, P. & Westerberg, L. S., Oct 27 2017, In : Genome Medicine. 9, 1, 91.

    Research output: Contribution to journalArticle

    T Cell Transcription Factor 1
    Wiskott-Aldrich Syndrome Protein
    Nuclear Proteins
    T-Lymphocytes
    Thymocytes
    2016

    Functional analyses of the Crohn's disease risk gene LACC1

    Assadi, G., Vesterlund, L., Bonfiglio, F., Mazzurana, L., Cordeddu, L., Schepis, D., Mjösberg, J., Ruhrmann, S., Fabbri, A., Vukojevic, V., Percipalle, P., Salomons, F. A., Laurencikiene, J., Törkvist, L., Halfvarson, J. & D'Amato, M., Dec 1 2016, In : PLoS One. 11, 12, e0168276.

    Research output: Contribution to journalArticle

    Crohn disease
    Macrophages
    Crohn Disease
    Peroxisome Proliferator-Activated Receptors
    Peroxisomes

    In β-actin knockouts, epigenetic reprogramming and rDNA transcription inactivation lead to growth and proliferation defects

    Almuzzaini, B., Sarshad, A. A., Rahmanto, A. S., Hansson, M. L., Von Euler, A., Sangfelt, O., Visa, N., Farrants, A. K. Ö. & Percipalle, P., Aug 1 2016, In : FASEB Journal. 30, 8, p. 2860-2873 14 p.

    Research output: Contribution to journalArticle

    Transcription
    Ribosomal DNA
    Epigenomics
    Actins
    Defects

    Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I

    Dass, R. A., Sarshad, A. A., Carson, B. B., Feenstra, J. M., Kaur, A., Obrdlik, A., Parks, M. M., Prakash, V., Love, D. K., Pietras, K., Serra, R., Blanchard, S. C., Percipalle, P., Brown, A. M. C. & Vincent, C. T., Aug 1 2016, In : PLoS Genetics. 12, 8, e1006217.

    Research output: Contribution to journalArticle

    RNA Polymerase I
    DNA-directed RNA polymerase
    Ribosomal DNA
    tumor
    ribosomal DNA
    2015

    Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation

    Almuzzaini, B., Sarshad, A. A., Farrants, A. K. Ö. & Percipalle, P., Dec 12 2015, In : BMC Biology. 13, 1, 35.

    Research output: Contribution to journalArticle

    RNA Polymerase II
    transcriptional activation
    Transcription
    DNA-directed RNA polymerase
    Myosins
    2014

    Glycogen Synthase Kinase (GSK) 3β Phosphorylates and Protects Nuclear Myosin 1c from Proteasome-Mediated Degradation to Activate rDNA Transcription in Early G1 Cells

    Sarshad, A. A., Corcoran, M., Al-Muzzaini, B., Borgonovo-Brandter, L., Von Euler, A., Lamont, D., Visa, N. & Percipalle, P., Jan 1 2014, In : PLoS Genetics. 10, 6, e1004390.

    Research output: Contribution to journalArticle

    Glycogen Synthase Kinase 3
    proteasome endopeptidase complex
    Proteasome Endopeptidase Complex
    Myosins
    myosin

    MRNA biogenesis, from the gene to polysomes

    Percipalle, P., Jan 1 2014, In : Seminars in Cell and Developmental Biology. 32, 1 p.

    Research output: Contribution to journalEditorial

    RNA Transport
    Genetic Transcription
    Polyribosomes
    Protein Biosynthesis
    Messenger RNA

    New insight into role of myosin motors for activation of RNA polymerases

    Sarshad, A. A. & Percipalle, P., Jan 1 2014, In : International Review of Cell and Molecular Biology. 311, p. 183-230 48 p.

    Research output: Contribution to journalArticle

    DNA-Directed RNA Polymerases
    Myosins
    Actins
    Chemical activation
    Transcription
    RNA Transport
    Messenger RNA
    Ribonucleoproteins
    Spermatogenesis
    Actins
    2013

    Co-transcriptional nuclear actin dynamics

    Percipalle, P., Feb 14 2013, In : Nucleus (United States). 4, 1, p. 1-10 10 p.

    Research output: Contribution to journalReview article

    Actins
    Proteins
    Polymerization
    Microfilament Proteins
    RNA Polymerase II

    Nuclear Myosin 1c Facilitates the Chromatin Modifications Required to Activate rRNA Gene Transcription and Cell Cycle Progression

    Sarshad, A., Sadeghifar, F., Louvet, E., Mori, R., Böhm, S., Al-Muzzaini, B., Vintermist, A., Fomproix, N., Östlund, A. K. & Percipalle, P., Apr 15 2013, In : PLoS Genetics. 9, 3, e1003397.

    Research output: Contribution to journalArticle

    Myosins
    myosin
    rRNA Genes
    Chromatin
    chromatin

    The Transacting Factor CBF-A/Hnrnpab Binds to the A2RE/RTS Element of Protamine 2 mRNA and Contributes to Its Translational Regulation during Mouse Spermatogenesis

    Fukuda, N., Fukuda, T., Sinnamon, J., Hernandez-Hernandez, A., Izadi, M., Raju, C. S., Czaplinski, K. & Percipalle, P., Oct 1 2013, In : PLoS Genetics. 9, 10, e1003858.

    Research output: Contribution to journalArticle

    protamines
    Spermatogenesis
    spermatogenesis
    sperm
    translation (genetics)
    2012

    In vivo run-on assays to monitor nascent precursor RNA transcripts

    Percipalle, P. & Louvet, E., Jan 2 2012, Transcriptional Regulation: Methods and Protocols. p. 519-533 15 p. (Methods in Molecular Biology; vol. 809).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    RNA Precursors
    Fluorine
    Uridine
    Eukaryotic Cells
    DNA-Directed RNA Polymerases
    2011

    In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements

    Raju, C. S., Fukuda, N., López-Iglesias, C., Göritz, C., Visa, N. & Percipalle, P., Jun 1 2011, In : Molecular Biology of the Cell. 22, 11, p. 1864-1877 14 p.

    Research output: Contribution to journalArticle

    Response Elements
    varespladib methyl
    Calcium-Calmodulin-Dependent Protein Kinase Type 2
    Brain-Derived Neurotrophic Factor
    Neurons

    The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes

    Vintermist, A., Böhm, S., Sadeghifar, F., Louvet, E., Mansén, A., Percipalle, P. & Östlund Farrants, A. K., May 12 2011, In : PLoS One. 6, 4, e19184.

    Research output: Contribution to journalArticle

    Williams Syndrome
    Chromatin Assembly and Disassembly
    Transferases
    rRNA Genes
    Histones

    The F-actin severing protein cofilin-1 is required for RNA polymerase II transcription elongation

    Obrdlik, A. & Percipalle, P., Jan 1 2011, In : Nucleus. 2, 1, p. 72-79 8 p.

    Research output: Contribution to journalArticle

    Cofilin 1
    RNA Polymerase II
    Actins
    Proteins
    Chromatin Immunoprecipitation
    2010

    Nuclear functions of actin.

    Visa, N. & Percipalle, P., Apr 1 2010, In : Cold Spring Harbor perspectives in biology. 2, 4

    Research output: Contribution to journalReview article

    Actins
    Chromatin
    Microfilament Proteins
    Ribonucleoproteins
    Chromatin Assembly and Disassembly

    Nuclear myosin 1 is in complex with mature rRNA transcripts and associates with the nuclear pore basket

    Obrdlik, A., Louvet, E., Kukalev, A., Naschekin, D., Kiseleva, E., Fahrenkrog, B. & Percipalle, P., Jan 1 2010, In : FASEB Journal. 24, 1, p. 146-157 12 p.

    Research output: Contribution to journalArticle

    Nuclear Pore
    Myosins
    Actins
    Nuclear RNA
    Immunoelectron Microscopy
    2009

    Actin-associated hnRNP proteins as transacting factors in the control of mRNA transport and localization

    Percipalle, P., Raju, C. S. & Fukuda, N., Jan 1 2009, In : RNA Biology. 6, 2, p. 171-174 4 p.

    Research output: Contribution to journalReview article

    Heterogeneous-Nuclear Ribonucleoproteins
    Actins
    Messenger RNA
    Oligodendroglia
    Polyribosomes

    Analysis of nascent RNA transcripts by chromatin RNA immunoprecipitation

    Obrdlik, A. & Percipalle, P., Dec 1 2009, Chromatin Immunoprecipitation Assays: Methods and Protocols. p. 215-235 21 p. (Methods in Molecular Biology; vol. 567).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Chromatin Immunoprecipitation
    RNA
    RNA-Binding Proteins
    Chromatin
    Messenger RNA

    Physical and functional interaction between heterochromatin protein 1α and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U

    Ameyar-Zazoua, M., Souidi, M., Fritsch, L., Robin, P., Thomas, A., Hamiche, A., Percipalle, P., Ait-Si-Ali, S. & Harel-Bellan, A., Oct 9 2009, In : Journal of Biological Chemistry. 284, 41, p. 27974-27979 6 p.

    Research output: Contribution to journalArticle

    Heterogeneous-Nuclear Ribonucleoprotein U
    RNA-Binding Proteins
    Chromatin
    Gene Silencing
    Purification

    SAF-A/hnRNP-U localization in interphase and metaphase

    Kukalev, A. S., Lobov, I. B., Percipalle, P. & Podgornaya, O. I., Jun 1 2009, In : Cytogenetic and Genome Research. 124, 3-4, p. 288-297 10 p.

    Research output: Contribution to journalArticle

    Heterogeneous-Nuclear Ribonucleoprotein U
    Interphase
    Metaphase
    Chromosomes
    Matrix Attachment Regions

    The long journey of actin and actin-associated proteins from genes to polysomes

    Percipalle, P., Jul 1 2009, In : Cellular and Molecular Life Sciences. 66, 13, p. 2151-2165 15 p.

    Research output: Contribution to journalReview article

    Polyribosomes
    Actins
    RNA
    Ribonucleoproteins
    Proteins
    2008

    Chapter 3 Transcriptional Control of Gene Expression by Actin and Myosin

    Louvet, E. & Percipalle, P., Dec 1 2008, In : International Review of Cell and Molecular Biology. 272, C, p. 107-147 41 p.

    Research output: Contribution to journalReview article

    Myosins
    Gene expression
    Actins
    Gene Expression
    Transcription

    In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences

    Raju, C. S., Göritz, C., Nord, Y., Hermanson, O., López-Iglesias, C., Visa, N., Castelo-Branco, G. & Percipalle, P., Jul 1 2008, In : Molecular Biology of the Cell. 19, 7, p. 3008-3019 12 p.

    Research output: Contribution to journalArticle

    Heterogeneous-Nuclear Ribonucleoproteins
    Myelin Basic Protein
    Oligodendroglia
    Prosencephalon
    Messenger RNA

    The glycogen synthase kinase (GSK) 3β represses RNA polymerase I transcription

    Vincent, T., Kukalev, A., Andäng, M., Pettersson, R. & Percipalle, P., Sep 4 2008, In : Oncogene. 27, 39, p. 5254-5259 6 p.

    Research output: Contribution to journalArticle

    RNA Polymerase I
    Glycogen Synthase Kinase 3
    Epithelial Cells
    PTEN Phosphohydrolase
    Tumor Suppressor Proteins

    The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription

    Obrdlik, A., Kukalev, A., Louvet, E., Farrants, A. K. Ö., Caputo, L. & Percipalle, P., Oct 1 2008, In : Molecular and Cellular Biology. 28, 20, p. 6342-6357 16 p.

    Research output: Contribution to journalArticle

    Heterogeneous-Nuclear Ribonucleoprotein U
    Histone Acetyltransferases
    RNA Polymerase II
    Actins
    Heterogeneous-Nuclear Ribonucleoproteins
    2007

    Genetic connections of the actin cytoskeleton and beyond

    Percipalle, P., May 1 2007, In : BioEssays. 29, 5, p. 407-411 5 p.

    Research output: Contribution to journalArticle

    Actin Cytoskeleton
    Actins
    Genes
    Cell signaling
    Protein Biosynthesis

    The function of actin in gene transcription

    Obrdlik, A., Kukalev, A. & Percipalle, P., Jul 1 2007, In : Histology and Histopathology. 22, 7-9, p. 1051-1055 5 p.

    Research output: Contribution to journalReview article

    Actins
    Genes
    Heterogeneous-Nuclear Ribonucleoproteins
    Ribosomal Proteins
    DNA-Directed RNA Polymerases
    2006

    Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1

    Percipalle, P. & Farrants, A. K. Ö., Jun 1 2006, In : Current Opinion in Cell Biology. 18, 3, p. 267-274 8 p.

    Research output: Contribution to journalReview article

    Chromatin Assembly and Disassembly
    Myosins
    Chromatin
    Euchromatin
    RNA Polymerase I

    Molecular functions of nuclear actin in transcription

    Percipalle, P. & Visa, N., Mar 1 2006, In : Journal of Cell Biology. 172, 7, p. 967-971 5 p.

    Research output: Contribution to journalShort survey

    Actins
    MHC Class II Genes
    RNA-Binding Proteins
    RNA Polymerase II
    Eukaryotic Cells

    The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription

    Percipalle, P., Fomproix, N., Cavellán, E., Voit, R., Reimer, G., Krüger, T., Thyberg, J., Scheer, U., Grummt, I. & Östlund Farrants, A. K., May 1 2006, In : EMBO Reports. 7, 5, p. 525-530 6 p.

    Research output: Contribution to journalArticle

    Williams Syndrome
    RNA Polymerase I
    Chromatin Assembly and Disassembly
    Transcription
    Myosins

    The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription

    Cavellán, E., Asp, P., Percipalle, P. & Farrants, A. K. Ö., Jun 16 2006, In : Journal of Biological Chemistry. 281, 24, p. 16264-16271 8 p.

    Research output: Contribution to journalArticle

    Williams Syndrome
    Chromatin Assembly and Disassembly
    Transcription
    Nuclear Proteins
    Chromatin
    2005

    Actin and hnRNP U cooperate for productive transcription by RNA polymerase II

    Kukalev, A., Nord, Y., Palmberg, C., Bergman, T. & Percipalle, P., Dec 1 2005, In : Nature Structural and Molecular Biology. 12, 3, p. 238-244 7 p.

    Research output: Contribution to journalArticle

    Heterogeneous-Nuclear Ribonucleoprotein U
    RNA Polymerase II
    Actins
    Microfilament Proteins
    Ribonucleoproteins
    2004

    An actin-myosin complex on actively transcribing genes

    Fomproix, N. & Percipalle, P., Mar 10 2004, In : Experimental Cell Research. 294, 1, p. 140-148 9 p.

    Research output: Contribution to journalArticle

    Myosins
    Actins
    Genes
    RNA Polymerase I
    Holoenzymes
    2003

    An actin-ribonucleoprotein interaction is involved in transcription by RNA polymerase II

    Percipalle, P., Fomproix, N., Kylberg, K., Miralles, F., Björkroth, B., Daneholt, B. & Visa, N., May 27 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 11, p. 6475-6480 6 p.

    Research output: Contribution to journalArticle

    Ribonucleoproteins
    RNA Polymerase II
    Actins
    Microfilament Proteins
    Chironomidae
    2002

    Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins

    Percipalle, P., Jonsson, A., Nashchekin, D., Karlsson, C., Bergman, T., Guialis, A. & Daneholt, B., Apr 15 2002, In : Nucleic Acids Research. 30, 8, p. 1725-1734 10 p.

    Research output: Contribution to journalArticle

    Heterogeneous-Nuclear Ribonucleoprotein Group A-B
    Actins
    Cytoplasm
    Heterogeneous-Nuclear Ribonucleoproteins
    Proteins
    2001

    Actin bound to the heterogeneous nuclear ribonucleoprotein hrp36 is associated with Balbiani ring mRNA from the gene to polysomes

    Percipalle, P., Zhao, J., Pope, B., Weeds, A., Lindberg, U. & Daneholt, B., Apr 2 2001, In : Journal of Cell Biology. 153, 1, p. 229-235 7 p.

    Research output: Contribution to journalArticle

    Chromosomal Puffs
    Heterogeneous-Nuclear Ribonucleoproteins
    Polyribosomes
    Actins
    Messenger RNA

    Recovery of gel-separated proteins for in-solution digestion and mass spectrometry

    Jonsson, A. P., Aissouni, Y., Palmberg, C., Percipalle, P., Nordling, E., Daneholt, B., Jörnvall, H. & Bergman, T., Nov 15 2001, In : Analytical Chemistry. 73, 22, p. 5370-5377 8 p.

    Research output: Contribution to journalArticle

    Mass spectrometry
    Gels
    Recovery
    Proteins
    Membranes