Mary Cowman

Assoc. Dean for Bioengineering, Professor of Othopaedic Surgery

1974 …2019
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Research Output 1974 2019

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2019

Role of Hyaluronan in Inflammatory Effects on Human Articular Chondrocytes

Cowman, M., Shortt, C., Arora, S., Fu, Y., Villavieja, J., Rathore, J., Huang, X., Rakshit, T., Jung, G. I. & Kirsch, T., Jan 1 2019, In : Inflammation.

Research output: Contribution to journalArticle

Open Access
Hyaluronic Acid
Chondrocytes
Joints
Interleukin-1
Conditioned Culture Medium
2018

A competitive alphascreen assay for detection of hyaluronan

Huang, X., Schmidt, T. A., Shortt, C., Arora, S., Asari, A., Kirsch, T. & Cowman, M., Mar 1 2018, In : Glycobiology. 28, 3, p. 137-147 11 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Assays
Singlet Oxygen
CD44 Antigens
Aggrecans

Human pericardial proteoglycan 4 (lubricin): Implications for postcardiotomy intrathoracic adhesion formation

Park, D. S. J., Regmi, S. C., Svystonyuk, D. A., Teng, G., Belke, D., Turnbull, J., Guzzardi, D. G., Kang, S., Cowman, M., Schmidt, T. A. & Fedak, P. W. M., Jan 1 2018, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Proteoglycans
Myofibroblasts
Collagen
Pericardium
lubricin
2017

Hyaluronan and Hyaluronan Fragments

Cowman, M., Jan 1 2017, (Accepted/In press) In : Advances in Carbohydrate Chemistry and Biochemistry.

Research output: Contribution to journalArticle

Hyaluronic Acid
Molecular mass
Tissue
Hydrodynamics
Molecules
2016

Hyaluronan modulates growth factor induced mammary gland branching in a size dependent manner

Tolg, C., Yuan, H., Flynn, S. M., Basu, K., Ma, J., Tse, K. C. K., Kowalska, B., Vulkanesku, D., Cowman, M., McCarthy, J. B. & Turley, E. A., Oct 25 2016, (Accepted/In press) In : Matrix Biology.

Research output: Contribution to journalArticle

Hyaluronic Acid
Human Mammary Glands
Intercellular Signaling Peptides and Proteins
CD44 Antigens
Morphogenesis

Mutual macromolecular crowding as the basis for polymer solution non-ideality

Cowman, M., 2016, (Accepted/In press) In : Polymers for Advanced Technologies.

Research output: Contribution to journalArticle

Polymer solutions
Viscosity
Polymers
Colloids
Light scattering
2015

Determination of hyaluronan molecular mass distribution in human breast milk

Yuan, H., Amin, R., Ye, X., De La Motte, C. A. & Cowman, M., Apr 1 2015, In : Analytical Biochemistry. 474, p. 78-88 11 p.

Research output: Contribution to journalArticle

Molecular mass
Human Milk
Hyaluronic Acid
Myeloma Proteins
Ion Exchange Chromatography

Hyaluronan, inflamation, and breast cancer progression

Schwertfeger, K. L., Cowman, M., Telmer, P. G., Turley, E. A. & McCarthy, J. B., 2015, In : Frontiers in Immunology. 6, 236

Research output: Contribution to journalArticle

Hyaluronan, inflammation, and breast cancer progression

Schwertfeger, K. L., Cowman, M., Telmer, P. G., Turley, E. A. & McCarthy, J. B., 2015, In : Frontiers in Immunology. 6, JUN, 236.

Research output: Contribution to journalArticle

Hyaluronic Acid
Breast Neoplasms
Inflammation
Neoplasms
CD44 Antigens

The content and size of hyaluronan in biological fluids and tissues

Cowman, M., Lee, H. G., Schwertfeger, K. L., McCarthy, J. B. & Turley, E. A., 2015, In : Frontiers in Immunology. 6, JUN, 261.

Research output: Contribution to journalArticle

Hyaluronic Acid
Polymers
Cellular Microenvironment
Disaccharides
Toll-Like Receptors
2014

Clusterin and complement activation in exfoliation glaucoma

Doudevski, I., Rostagno, A., Cowman, M., Liebmann, J., Ritch, R. & Ghiso, J., Feb 18 2014, In : Investigative Ophthalmology and Visual Science. 55, 4, p. 2491-2499 9 p.

Research output: Contribution to journalArticle

Exfoliation Syndrome
Clusterin
Complement Activation
Lenses
Complement Membrane Attack Complex

Effects of concentration and structure on proteoglycan 4 rheology and interaction with hyaluronan

Ludwig, T. E., Cowman, M. K., Jay, G. D. & Schmidt, T. A., 2014, In : Biorheology. 51, 6, p. 409-422 14 p.

Research output: Contribution to journalArticle

Rheology
Proteoglycans
Hyaluronic Acid
Viscosity
Disulfides
2013

Human milk hyaluronan enhances innate defense of the intestinal epithelium

Hill, D. R., Rho, H. K., Kessler, S. P., Amin, R., Homer, C. R., McDonald, C., Cowman, M. & De La Motte, C. A., Oct 4 2013, In : Journal of Biological Chemistry. 288, 40, p. 29090-29104 15 p.

Research output: Contribution to journalArticle

Human Milk
Hyaluronic Acid
Intestinal Mucosa
Milk
Defensins

Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated hyaluronan binding protein

Yuan, H., Tank, M., Alsofyani, A., Shah, N., Talati, N., LoBello, J. C., Kim, J., Oonuki, Y., De La Motte, C. A. & Cowman, M., Nov 2013, In : Glycobiology. 23, 11, p. 1270-1280 11 p.

Research output: Contribution to journalArticle

CD44 Antigens
Immunosorbents
Molecular mass
Hyaluronic Acid
Assays
2012

A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds

Tolg, C., Hamilton, S. R., Zalinska, E., McCulloch, L., Amin, R., Akentieva, N., Winnik, F., Savani, R., Bagli, D. J., Luyt, L. G., Cowman, M., McCarthy, J. B. & Turley, E. A., Oct 2012, In : American Journal of Pathology. 181, 4, p. 1250-1270 21 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Inflammation
Skin
Peptides
Wounds and Injuries

Specific-sized hyaluronan fragments promote expression of human β-defensin 2 in intestinal epithelium

Hill, D. R., Kessler, S. P., Rho, H. K., Cowman, M. & De La Motte, C. A., Aug 31 2012, In : Journal of Biological Chemistry. 287, 36, p. 30610-30624 15 p.

Research output: Contribution to journalArticle

Defensins
Hyaluronic Acid
Intestinal Mucosa
Pattern Recognition Receptors
Polymers
2011

Agarose and polyacrylamide gel electrophoresis methods for molecular mass analysis of 5- to 500-kDa hyaluronan

Bhilocha, S., Ripal, A., Pandya, M., Yuan, H., Tank, M., LoBello, J., Shytuhina, A., Wang, W., Wisniewski, H. G., De La Motte, C. & Cowman, M., Oct 2011, In : Analytical Biochemistry. 417, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

Agar Gel Electrophoresis
Molecular mass
Hyaluronic Acid
Electrophoresis
Sepharose

Improved agarose gel electrophoresis method and molecular mass calculation for high molecular mass hyaluronan

Cowman, M., Chen, C. C., Pandya, M., Yuan, H., Ramkishun, D., LoBello, J., Bhilocha, S., Russell-Puleri, S., Skendaj, E., Mijovic, J. & Jing, W., Oct 2011, In : Analytical Biochemistry. 417, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Agar Gel Electrophoresis
Molecular mass
Hyaluronic Acid
Electrophoresis
Sepharose

The effect of molecular weight on hyaluronan's cartilage boundary lubricating ability - alone and in combination with proteoglycan 4

Kwiecinski, J. J., Dorosz, S. G., Ludwig, T. E., Abubacker, S., Cowman, M. & Schmidt, T. A., Nov 2011, In : Osteoarthritis and Cartilage. 19, 11, p. 1356-1362 7 p.

Research output: Contribution to journalArticle

Cartilage
Proteoglycans
Hyaluronic Acid
Molecular Weight
Molecular weight
2009

Transfer of inter-α-inhibitor heavy chains to hyaluronan by surface-linked hyaluronan-TSG-6 complexes

Colón, E., Shytuhina, A., Cowman, M., Band, P. A., Sanggaard, K. W., Enghild, J. J. & Wisniewski, H. G., Jan 23 2009, In : Journal of Biological Chemistry. 284, 4, p. 2320-2331 12 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Sepsis
Covalent bonds
Ovulation
Arthritis
2007

Effects of the proteinaceous moiety on the emulsifying properties of sugar beet pectin

Funami, T., Zhang, G., Hiroe, M., Noda, S., Nakauma, M., Asai, I., Cowman, M., Al-Assaf, S. & Phillips, G. O., Dec 2007, In : Food Hydrocolloids. 21, 8, p. 1319-1329 11 p.

Research output: Contribution to journalArticle

Sugar beets
Beta vulgaris
emulsifying properties
sugar beet
pectins
2006

Scanning electron and atomic force microscopy to study plasma torch effects on B. cereus spores

Tarasenko, O., Nourbakhsh, S., Kuo, S., Bakhtina, A., Alusta, P., Kudasheva, D., Cowman, M. & Levon, K., Aug 2006, In : IEEE Transactions on Plasma Science. 34, 4 II, p. 1281-1289 9 p.

Research output: Contribution to journalArticle

plasma torches
spores
atomic force microscopy
scanning
electrons

Use of atomic force microscopy to investigate the structure of arabinogalactan proteins

Cowman, M., Funami, T., Al-Assaf, S., Kudasheva, D. S., Mohan, D. & Phillips, G. O., 2006, In : Food & Food Ingredients Journal of Japan. 211, p. 207-212

Research output: Contribution to journalArticle

2005

Experimental approaches to hyaluronan structure

Cowman, M. & Matsuoka, S., Apr 11 2005, In : Carbohydrate Research. 340, 5, p. 791-809 19 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Polymers
Hydrodynamics
Putty
Salts

Extended, relaxed, and condensed conformations of hyaluronan observed by atomic force microscopy

Cowman, M., Spagnoli, C., Kudasheva, D., Li, M., Dyal, A., Kanai, S. & Balazs, E. A., Jan 2005, In : Biophysical Journal. 88, 1, p. 590-602 13 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Hyaluronic Acid
Water
Extracellular Space
Static Electricity

Hyaluronan conformations on surfaces: Effect of surface charge and hydrophobicity

Spagnoli, C., Korniakov, A., Ulman, A., Balazs, E. A., Lyubchenko, Y. L. & Cowman, M., Apr 11 2005, In : Carbohydrate Research. 340, 5, p. 929-941 13 p.

Research output: Contribution to journalArticle

Graphite
Hyaluronic Acid
Surface charge
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
2004

Facile Route to Ultraflat SAM-Protected Gold Surfaces by "Amphiphile Splitting"

Gupta, P., Loos, K., Korniakov, A., Spagnoli, C., Cowman, M. & Ulman, A., Jan 16 2004, In : Angewandte Chemie - International Edition. 43, 4, p. 520-523 4 p.

Research output: Contribution to journalArticle

Amphiphiles
Gold
Self assembled monolayers
Sulfhydryl Compounds
Contact angle

Structure of carbohydrate-bound polynuclear iron oxyhydroxide nanoparticles in parenteral formulations

Kudasheva, D. S., Lai, J., Ulman, A. & Cowman, M., Nov 2004, In : Journal of Inorganic Biochemistry. 98, 11, p. 1757-1769 13 p.

Research output: Contribution to journalArticle

saccharated ferric oxide
Nanoparticles
Iron
Carbohydrates
Minerals
2003

Activity of Candida rugosa lipase immobilized on γ-Fe2O3 magnetic nanoparticles

Dyal, A., Loos, K., Noto, M., Chang, S. W., Spagnoli, C., Shafi, K. V. P. M., Ulman, A., Cowman, M. & Gross, R. A., Feb 15 2003, In : Journal of the American Chemical Society. 125, 7, p. 1684-1685 2 p.

Research output: Contribution to journalArticle

Candida
Lipases
Lipase
Nanoparticles
Amines

Atomic force microscopy of hyaluronan polysaccharide on differing surfaces

Spagnoli, C., Lyubchenko, Y. L., Balazs, EA. & Cowman, M., 2003, In : Biophysical Journal.

Research output: Contribution to journalArticle

Imaging structured water and bound polysaccharide on mica surface at ambient temperature

Spagnoli, C., Loos, K., Ulman, A. & Cowman, M., Jun 11 2003, In : Journal of the American Chemical Society. 125, 23, p. 7124-7128 5 p.

Research output: Contribution to journalArticle

Mica
Polysaccharides
Imaging techniques
Temperature
Water

Poly(N-isopropylacrylamide-co-1-vinylimidazole) hydrogel nanoparticles prepared and hydrophobically modified in liposome reactors: Atomic force microscopy and dynamic light scattering study

Kazakov, S., Kaholek, M., Kudasheva, D., Teraoka, I., Cowman, M. & Levon, K., Sep 16 2003, In : Langmuir. 19, 19, p. 8086-8093 8 p.

Research output: Contribution to journalArticle

Liposomes
Hydrogel
Dynamic light scattering
Hydrogels
lipids

Poly(vinyl alcohol) as versatile biomaterial for potential biomedical applications

Paradossi, G., Cavalieri, F., Chiessi, E., Spagnoli, C. & Cowman, M., Aug 1 2003, In : Journal of Materials Science: Materials in Medicine. 14, 8, p. 687-691 5 p.

Research output: Contribution to journalArticle

Hydrogels
Biocompatible Materials
Biomaterials
Genetic Therapy
Alcohols
2002

Equation of state for polymer solution

Matsuoka, S. & Cowman, M., Apr 15 2002, In : Polymer. 43, 12, p. 3447-3453 7 p.

Research output: Contribution to journalArticle

Polymer solutions
Equations of state
Polymers
Viscosity
Polyelectrolytes
2001

13C NMR studies of hyaluronan. 2. Dependence of conformational dynamics on chain length and solvent

Cowman, M., Feder-Davis, J. & Hittner, D. M., Jan 2001, In : Macromolecules. 34, 1, p. 110-115 6 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Chain length
Nuclear magnetic resonance
Relaxation time
Conformations
2000

Concentration dependence of solution viscosities of rigid rod polymers

Kwei, T. K., Nakazawa, M., Matsuoka, S., Cowman, M. & Okamoto, Y., 2000, In : Macromolecules. 33, 2, p. 235-236 2 p.

Research output: Contribution to journalArticle

Gel permeation chromatography
Polymers
Molecular weight
Viscosity
Organic solvents

Molecular dynamics and kinetics of monosaccharides in solution. A broadband ultrasonic relaxation study

Stenger, J., Cowman, M., Eggers, F., Eyring, E. M., Kaatze, U. & Petrucci, S., May 18 2000, In : Journal of Physical Chemistry B. 104, 19, p. 4782-4790 9 p.

Research output: Contribution to journalArticle

Ultrasonic relaxation
monosaccharides
Monosaccharides
Molecular dynamics
carbohydrates

Tapping mode atomic force microscopy of the hyaluronan derivative, hylan A

Cowman, M., Li, M., Dyal, A. & Balazs, E. A., Mar 2000, In : Carbohydrate Polymers. 41, 3, p. 229-235 7 p.

Research output: Contribution to journalArticle

hyaluronic acid
atomic force microscopy
Atomic Force Microscopy
Hyaluronic Acid
Atomic force microscopy

Thermal analysis of semi-dilute hyaluronan solutions

Liu, J. & Cowman, M., 2000, In : Journal of Thermal Analysis and Calorimetry. 59, 1, p. 547-557 11 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Thermoanalysis
thermal analysis
Water
water
1999

Another model for linear viscoelasticity of polymer solutions

Matsuoka, S., Cowman, M., Balazs, E. A. & Hoefling, J. M., 1999, Bulletin of the American Physical Society, 44, p. 1186.

Research output: Contribution to specialist publicationArticle

Microsecond to subnanosecond molecular relaxation dynamics of the interaction of Ca2+ with some carbohydrates in aqueous solution

Cowman, M., Eggers, F., Eyring, E. M., Horoszewski, D., Kaatze, U., Kreitner, R., Petrucci, S., Klöppel-Riech, M. & Stenger, J., Jan 7 1999, In : Journal of Physical Chemistry B. 103, 1, p. 239-242 4 p.

Research output: Contribution to journalArticle

carbohydrates
molecular relaxation
Carbohydrates
aqueous solutions
Relaxation processes
1998

Atomic force microscopy of hyaluronan

Li, M. & Cowman, MK., Feb 1998, In : Biophysical Journal. 74, 2, p. A226

Research output: Contribution to journalArticle

Tapping mode atomic force microscopy of hyaluronan: Extended and intramolecularly interacting chains

Cowman, M., Li, M. & Balazs, E. A., Oct 1998, In : Biophysical Journal. 75, 4, p. 2030-2037 8 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Hyaluronic Acid
Extracellular Matrix
Polysaccharides
Molecular Weight
1997

Degradation of hyaluronan by peroxynitrite

Li, M., Rosenfeld, L., Vilar, R. E. & Cowman, M., May 15 1997, In : Archives of Biochemistry and Biophysics. 341, 2, p. 245-250 6 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Hyaluronic Acid
Degradation
Hydroxyl Radical
Molecular Weight

Nitric oxide degradation of heparin and heparan sulphate

Vilar, R. E., Ghael, D., Li, M., Bhagat, D. D., Arrigo, L. M., Cowman, M., Dweck, H. S. & Rosenfeld, L., Jun 1 1997, In : Biochemical Journal. 324, 2, p. 473-479 7 p.

Research output: Contribution to journalArticle

Heparitin Sulfate
Heparin
Nitric Oxide
Degradation
Endothelial cells
Ultrasonic relaxation
Carbohydrates
Ultrasonics
Reaction kinetics
Glucose
Ultrasonic relaxation
Carbohydrates
Ultrasonics
Reaction kinetics
Glucose

Ultrasonic relaxation and fast chemical kinetics of some carbohydrate aqueous solutions

Behrends, R., Cowman, M., Eggers, F., Eyring, E. M., Kaatze, U., Majewski, J., Petrucci, S., Richmann, K. H. & Riech, M., 1997, In : Journal of the American Chemical Society. 119, 9, p. 2182-2186 5 p.

Research output: Contribution to journalArticle

Ultrasonic relaxation
Carbohydrates
Ultrasonics
Reaction kinetics
Glucose