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Mary Cowman

Assoc. Dean for Bioengineering, Professor of Othopaedic Surgery

1974 …2019
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Research Output 1974 2019

2019

Methods for hyaluronan molecular mass determination by agarose gel electrophoresis

Cowman, M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 91-102 12 p. (Methods in Molecular Biology; vol. 1952).

Research output: Chapter in Book/Report/Conference proceedingChapter

Agar Gel Electrophoresis
Hyaluronic Acid
Reactive Nitrogen Species
Cell Surface Receptors
Reactive Oxygen Species

Role of Hyaluronan in Inflammatory Effects on Human Articular Chondrocytes

Cowman, M., Shortt, C., Arora, S., Fu, Y., Villavieja, J., Rathore, J., Huang, X., Rakshit, T., Jung, G. I. & Kirsch, T., Jan 1 2019, In : Inflammation.

Research output: Contribution to journalArticle

Open Access
Hyaluronic Acid
Chondrocytes
Joints
Interleukin-1
Conditioned Culture Medium
2016

Hyaluronan modulates growth factor induced mammary gland branching in a size dependent manner

Tolg, C., Yuan, H., Flynn, S. M., Basu, K., Ma, J., Tse, K. C. K., Kowalska, B., Vulkanesku, D., Cowman, M., McCarthy, J. B. & Turley, E. A., Oct 25 2016, (Accepted/In press) In : Matrix Biology.

Research output: Contribution to journalArticle

Hyaluronic Acid
Human Mammary Glands
Intercellular Signaling Peptides and Proteins
CD44 Antigens
Morphogenesis

Mutual macromolecular crowding as the basis for polymer solution non-ideality

Cowman, M., 2016, (Accepted/In press) In : Polymers for Advanced Technologies.

Research output: Contribution to journalArticle

Polymer solutions
Viscosity
Polymers
Colloids
Light scattering
2015

Hyaluronan, inflamation, and breast cancer progression

Schwertfeger, K. L., Cowman, M., Telmer, P. G., Turley, E. A. & McCarthy, J. B., 2015, In : Frontiers in Immunology. 6, 236

Research output: Contribution to journalArticle

Hyaluronan, inflammation, and breast cancer progression

Schwertfeger, K. L., Cowman, M., Telmer, P. G., Turley, E. A. & McCarthy, J. B., 2015, In : Frontiers in Immunology. 6, JUN, 236.

Research output: Contribution to journalArticle

Hyaluronic Acid
Breast Neoplasms
Inflammation
Neoplasms
CD44 Antigens

Viscoelastic properties of hyaluronan in physiological conditions

Cowman, M., Schmidt, T. A., Raghavan, P. & Stecco, A., 2015, F1000Reseach, p. http://f1000research.com/articles/4-622/v1.

Research output: Working paper

2013

Human milk hyaluronan enhances innate defense of the intestinal epithelium

Hill, D. R., Rho, H. K., Kessler, S. P., Amin, R., Homer, C. R., McDonald, C., Cowman, M. & De La Motte, C. A., Oct 4 2013, In : Journal of Biological Chemistry. 288, 40, p. 29090-29104 15 p.

Research output: Contribution to journalArticle

Human Milk
Hyaluronic Acid
Intestinal Mucosa
Milk
Defensins
2012

Macromolecular crowding in biomatrix

Cowman, M., Hernandez, M. & Kim, J., 2012, Structure and function of biomatrix: Control of cell function and gene expression. Balazs, E. A. & Hargittai, M. (eds.). Edgewater, NJ: Matrix Biology Institue, p. 45-66

Research output: Chapter in Book/Report/Conference proceedingChapter

Defensins
Hyaluronic Acid
Intestinal Mucosa
Pattern Recognition Receptors
Polymers
Defensins
Hyaluronic Acid
Intestinal Mucosa
Pattern Recognition Receptors
Polymers
Defensins
Hyaluronic Acid
Intestinal Mucosa
Pattern Recognition Receptors
Polymers
Defensins
Hyaluronic Acid
Intestinal Mucosa
Pattern Recognition Receptors
Polymers

Specific-sized hyaluronan fragments promote expression of human β-defensin 2 in intestinal epithelium

Hill, D. R., Kessler, S. P., Rho, H. K., Cowman, M. & De La Motte, C. A., Aug 31 2012, In : Journal of Biological Chemistry. 287, 36, p. 30610-30624 15 p.

Research output: Contribution to journalArticle

Defensins
Hyaluronic Acid
Intestinal Mucosa
Pattern Recognition Receptors
Polymers
2011

Agarose and polyacrylamide gel electrophoresis methods for molecular mass analysis of 5- to 500-kDa hyaluronan

Bhilocha, S., Ripal, A., Pandya, M., Yuan, H., Tank, M., LoBello, J., Shytuhina, A., Wang, W., Wisniewski, H. G., De La Motte, C. & Cowman, M., Oct 2011, In : Analytical Biochemistry. 417, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

Agar Gel Electrophoresis
Molecular mass
Hyaluronic Acid
Electrophoresis
Sepharose

Improved agarose gel electrophoresis method and molecular mass calculation for high molecular mass hyaluronan

Cowman, M., Chen, C. C., Pandya, M., Yuan, H., Ramkishun, D., LoBello, J., Bhilocha, S., Russell-Puleri, S., Skendaj, E., Mijovic, J. & Jing, W., Oct 2011, In : Analytical Biochemistry. 417, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Agar Gel Electrophoresis
Molecular mass
Hyaluronic Acid
Electrophoresis
Sepharose

The effect of molecular weight on hyaluronan's cartilage boundary lubricating ability - alone and in combination with proteoglycan 4

Kwiecinski, J. J., Dorosz, S. G., Ludwig, T. E., Abubacker, S., Cowman, M. & Schmidt, T. A., Nov 2011, In : Osteoarthritis and Cartilage. 19, 11, p. 1356-1362 7 p.

Research output: Contribution to journalArticle

Cartilage
Proteoglycans
Hyaluronic Acid
Molecular Weight
Molecular weight
2008

Carbohydrate Chemistry, Biology and Medical Applications

Garg, H. G., Cowman, M. & Hales, C. A., 2008, Elsevier Ltd.

Research output: Book/ReportBook

Medical applications
Carbohydrates
Drug products
Animals
Pharmaceutical Preparations
2007

Effects of the proteinaceous moiety on the emulsifying properties of sugar beet pectin

Funami, T., Zhang, G., Hiroe, M., Noda, S., Nakauma, M., Asai, I., Cowman, M., Al-Assaf, S. & Phillips, G. O., Dec 2007, In : Food Hydrocolloids. 21, 8, p. 1319-1329 11 p.

Research output: Contribution to journalArticle

Sugar beets
Beta vulgaris
emulsifying properties
sugar beet
pectins
2006

Scanning electron and atomic force microscopy to study plasma torch effects on B. cereus spores

Tarasenko, O., Nourbakhsh, S., Kuo, S., Bakhtina, A., Alusta, P., Kudasheva, D., Cowman, M. & Levon, K., Aug 2006, In : IEEE Transactions on Plasma Science. 34, 4 II, p. 1281-1289 9 p.

Research output: Contribution to journalArticle

plasma torches
spores
atomic force microscopy
scanning
electrons

Use of atomic force microscopy to investigate the structure of arabinogalactan proteins

Cowman, M., Funami, T., Al-Assaf, S., Kudasheva, D. S., Mohan, D. & Phillips, G. O., 2006, In : Food & Food Ingredients Journal of Japan. 211, p. 207-212

Research output: Contribution to journalArticle

2004

Facile Route to Ultraflat SAM-Protected Gold Surfaces by "Amphiphile Splitting"

Gupta, P., Loos, K., Korniakov, A., Spagnoli, C., Cowman, M. & Ulman, A., Jan 16 2004, In : Angewandte Chemie - International Edition. 43, 4, p. 520-523 4 p.

Research output: Contribution to journalArticle

Amphiphiles
Gold
Self assembled monolayers
Sulfhydryl Compounds
Contact angle

Structure of carbohydrate-bound polynuclear iron oxyhydroxide nanoparticles in parenteral formulations

Kudasheva, D. S., Lai, J., Ulman, A. & Cowman, M., Nov 2004, In : Journal of Inorganic Biochemistry. 98, 11, p. 1757-1769 13 p.

Research output: Contribution to journalArticle

saccharated ferric oxide
Nanoparticles
Iron
Carbohydrates
Minerals
2003

Activity of Candida rugosa lipase immobilized on γ-Fe2O3 magnetic nanoparticles

Dyal, A., Loos, K., Noto, M., Chang, S. W., Spagnoli, C., Shafi, K. V. P. M., Ulman, A., Cowman, M. & Gross, R. A., Feb 15 2003, In : Journal of the American Chemical Society. 125, 7, p. 1684-1685 2 p.

Research output: Contribution to journalArticle

Candida
Lipases
Lipase
Nanoparticles
Amines

Atomic force microscopy of hyaluronan polysaccharide on differing surfaces

Spagnoli, C., Lyubchenko, Y. L., Balazs, EA. & Cowman, M., 2003, In : Biophysical Journal.

Research output: Contribution to journalArticle

Imaging structured water and bound polysaccharide on mica surface at ambient temperature

Spagnoli, C., Loos, K., Ulman, A. & Cowman, M., Jun 11 2003, In : Journal of the American Chemical Society. 125, 23, p. 7124-7128 5 p.

Research output: Contribution to journalArticle

Mica
Polysaccharides
Imaging techniques
Temperature
Water

Poly(N-isopropylacrylamide-co-1-vinylimidazole) hydrogel nanoparticles prepared and hydrophobically modified in liposome reactors: Atomic force microscopy and dynamic light scattering study

Kazakov, S., Kaholek, M., Kudasheva, D., Teraoka, I., Cowman, M. & Levon, K., Sep 16 2003, In : Langmuir. 19, 19, p. 8086-8093 8 p.

Research output: Contribution to journalArticle

Liposomes
Hydrogel
Dynamic light scattering
Hydrogels
lipids

Poly(vinyl alcohol) as versatile biomaterial for potential biomedical applications

Paradossi, G., Cavalieri, F., Chiessi, E., Spagnoli, C. & Cowman, M., Aug 1 2003, In : Journal of Materials Science: Materials in Medicine. 14, 8, p. 687-691 5 p.

Research output: Contribution to journalArticle

Hydrogels
Biocompatible Materials
Biomaterials
Genetic Therapy
Alcohols
2002

Tapping mode atomic force microscopy of hyaluronan and hylan A

Cowman, M., Li, M., Dyal, A. & Kanai, S., 2002, Hyaluronan. Kennedy, J. F., Phillips, G. O. & Williams, P. A. (eds.). Cambridge: Woodhead Publishing, p. 109-116

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Temperature effect on the dynamic rheological characteristics of hyaluronan, hylan A, and synvisc

Hoefling, J. M., Cowman, M., Matsuoka, S. & Balazs, E. A., 2002, Hyaluronan. Kennedy, J. F., Phillips, G. O. & Williams, P. A. (eds.). Cambridge: Woodhead Publishing, p. 103-108

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Viscosity of polymer solutions revisited

Matsuoka, S. & Cowman, M., 2002, Hyaluronan. Kennedy, J. F., Phillips, G. O. & Williams, P. A. (eds.). Cambridge: Woodhead Publishing, p. 79-88

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2001

13C NMR studies of hyaluronan. 2. Dependence of conformational dynamics on chain length and solvent

Cowman, M., Feder-Davis, J. & Hittner, D. M., Jan 2001, In : Macromolecules. 34, 1, p. 110-115 6 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Chain length
Nuclear magnetic resonance
Relaxation time
Conformations
2000

Concentration dependence of solution viscosities of rigid rod polymers

Kwei, T. K., Nakazawa, M., Matsuoka, S., Cowman, M. & Okamoto, Y., 2000, In : Macromolecules. 33, 2, p. 235-236 2 p.

Research output: Contribution to journalArticle

Gel permeation chromatography
Polymers
Molecular weight
Viscosity
Organic solvents
Ultrasonic relaxation
monosaccharides
Monosaccharides
Molecular dynamics
carbohydrates
Ultrasonic relaxation
monosaccharides
Monosaccharides
Molecular dynamics
carbohydrates
Ultrasonic relaxation
monosaccharides
Monosaccharides
Molecular dynamics
carbohydrates
Ultrasonic relaxation
monosaccharides
Monosaccharides
Molecular dynamics
carbohydrates

Molecular dynamics and kinetics of monosaccharides in solution. A broadband ultrasonic relaxation study

Stenger, J., Cowman, M., Eggers, F., Eyring, E. M., Kaatze, U. & Petrucci, S., May 18 2000, In : Journal of Physical Chemistry B. 104, 19, p. 4782-4790 9 p.

Research output: Contribution to journalArticle

Ultrasonic relaxation
monosaccharides
Monosaccharides
Molecular dynamics
carbohydrates

Tapping mode atomic force microscopy of the hyaluronan derivative, hylan A

Cowman, M., Li, M., Dyal, A. & Balazs, E. A., Mar 2000, In : Carbohydrate Polymers. 41, 3, p. 229-235 7 p.

Research output: Contribution to journalArticle

hyaluronic acid
atomic force microscopy
Atomic Force Microscopy
Hyaluronic Acid
Atomic force microscopy

Thermal analysis of semi-dilute hyaluronan solutions

Liu, J. & Cowman, M., 2000, In : Journal of Thermal Analysis and Calorimetry. 59, 1, p. 547-557 11 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Thermoanalysis
thermal analysis
Water
water
1999

Another model for linear viscoelasticity of polymer solutions

Matsuoka, S., Cowman, M., Balazs, E. A. & Hoefling, J. M., 1999, Bulletin of the American Physical Society, 44, p. 1186.

Research output: Contribution to specialist publicationArticle

Microsecond to subnanosecond molecular relaxation dynamics of the interaction of Ca2+ with some carbohydrates in aqueous solution

Cowman, M., Eggers, F., Eyring, E. M., Horoszewski, D., Kaatze, U., Kreitner, R., Petrucci, S., Klöppel-Riech, M. & Stenger, J., Jan 7 1999, In : Journal of Physical Chemistry B. 103, 1, p. 239-242 4 p.

Research output: Contribution to journalArticle

carbohydrates
molecular relaxation
Carbohydrates
aqueous solutions
Relaxation processes
1998

Atomic force microscopy of hyaluronan

Li, M. & Cowman, MK., Feb 1998, In : Biophysical Journal. 74, 2, p. A226

Research output: Contribution to journalArticle

Hyaluronan interactions: self, water, ions

Cowman, M., Liu, J., Li, M., Hittner, D. M. & Kim, J. S., 1998, The chemistry, biology and medical applications of hyaluronan and its derivatives. Laurent, T. C. (ed.). London: Portland Press, p. 17-24 (Wenner-Gren International Series; no. 72).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Tapping mode atomic force microscopy of hyaluronan: Extended and intramolecularly interacting chains

Cowman, M., Li, M. & Balazs, E. A., Oct 1998, In : Biophysical Journal. 75, 4, p. 2030-2037 8 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Hyaluronic Acid
Extracellular Matrix
Polysaccharides
Molecular Weight
1997

Degradation of hyaluronan by peroxynitrite

Li, M., Rosenfeld, L., Vilar, R. E. & Cowman, M., May 15 1997, In : Archives of Biochemistry and Biophysics. 341, 2, p. 245-250 6 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Hyaluronic Acid
Degradation
Hydroxyl Radical
Molecular Weight

Nitric oxide degradation of heparin and heparan sulphate

Vilar, R. E., Ghael, D., Li, M., Bhagat, D. D., Arrigo, L. M., Cowman, M., Dweck, H. S. & Rosenfeld, L., Jun 1 1997, In : Biochemical Journal. 324, 2, p. 473-479 7 p.

Research output: Contribution to journalArticle

Heparitin Sulfate
Heparin
Nitric Oxide
Degradation
Endothelial cells
Ultrasonic relaxation
Carbohydrates
Ultrasonics
Reaction kinetics
Glucose

Ultrasonic relaxation and fast chemical kinetics of some carbohydrate aqueous solutions

Behrends, R., Cowman, M., Eggers, F., Eyring, E. M., Kaatze, U., Majewski, J., Petrucci, S., Richmann, K. H. & Riech, M., 1997, In : Journal of the American Chemical Society. 119, 9, p. 2182-2186 5 p.

Research output: Contribution to journalArticle

Ultrasonic relaxation
Carbohydrates
Ultrasonics
Reaction kinetics
Glucose