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Lukasz Witek

Assistant Professor

 https://orcid.org/0000-0003-1458-6527
20102020
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Research Output 2010 2020

  • 62 Article
  • 4 Conference contribution
  • 2 Review article
  • 1 Comment/debate
2020

Implant-abutment fit influences the mechanical performance of single-crown prostheses

Ramalho, I. S., Bergamo, E. T. P., Witek, L., Coelho, P. G., Lopes, A. C. O. & Bonfante, E. A., Feb 2020, In : Journal of the Mechanical Behavior of Biomedical Materials. 102, 103506.

Research output: Contribution to journal › Article

Prosthetics
Fatigue of materials
Failure modes
Cements
Fractography
2019

Absence of Healing Impairment in Osteotomies Prepared via Osseodensification Drilling

Witek, L., Neiva, R., Alifarag, A., Shahraki, F., Sayah, G., Tovar, N., Lopez, C. D., Gil, L. & Coelho, P., Jan 1 2019, In : The International journal of periodontics & restorative dentistry. 39, 1, p. 65-71 7 p.

Research output: Contribution to journal › Article

Osteotomy
Sheep
Ilium
Mandrillus
Bone Remodeling

Alveolar Ridge Expansion: Comparison of Osseodensification and Conventional Osteotome Techniques

Tian, J. H., Neiva, R., Coelho, P., Witek, L., Tovar, N. M., Lo, I. C., Gil, L. F. & Torroni, A., Mar 1 2019, In : The Journal of craniofacial surgery. 30, 2, p. 607-610 4 p.

Research output: Contribution to journal › Article

Alveolar Process
Osseointegration
Bone and Bones
Bicuspid
Sample Size

Biomaterial and biomechanical considerations to prevent risks in implant therapy

Bonfante, E. A., Jimbo, R., Witek, L., Tovar, N., Neiva, R., Torroni, A. & Coelho, P., Jan 1 2019, In : Periodontology 2000. 81, 1, p. 139-151 13 p.

Research output: Contribution to journal › Review article

Biocompatible Materials
Rehabilitation
Osseointegration
Bone and Bones
Mental Competency

Comparative in vitro study of 3D robocasting scaffolds using beta tricalcium phosphate and synthetic bone mineral

Rivera, C., Witek, L., Mijares, D., Larranaga-Vega, A., Cronstein, B. N. & Coelho, P., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Scaffolds
Minerals
Bone
Phosphates
Bone and Bones

Dipyridamole Augments Three-Dimensionally Printed Bioactive Ceramic Scaffolds to Regenerate Craniofacial Bone

Lopez, C. D., Diaz-Siso, J. R., Witek, L., Bekisz, J. M., Gil, L. F., Cronstein, B. N., Flores, R. L., Torroni, A., Rodriguez, E. D. & Coelho, P., May 1 2019, In : Plastic and reconstructive surgery. 143, 5, p. 1408-1419 12 p.

Research output: Contribution to journal › Article

Dipyridamole
Ceramics
Bone and Bones
Collagen
Bone Development

In-house manufacture of sterilizable, scaled, patient-specific 3D-printed models for rhinoplasty

Bekisz, J. M., Liss, H. A., Maliha, S. G., Witek, L., Coelho, P. & Flores, R. L., Feb 15 2019, In : Aesthetic Surgery Journal. 39, 3, p. 254-263 10 p.

Research output: Contribution to journal › Article

Open Access
Rhinoplasty
Communication
Anatomic Models
Costs and Cost Analysis
Printing

Long-term outcomes of 3D-printed bioactive ceramic scaffolds for regeneration of the pediatric skeleton

Wang, M. M., Rodriguez Colon, R., Kurgansky, G. D., Witek, L., Torroni, A., Cronstein, B. N., Flores, R. L. & Coelho, P., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Pediatrics
Ceramics
Skeleton
Scaffolds
Regeneration

Nanomechanical and microstructural characterization of a zirconia-toughened alumina composite after aging

Lopes, A. C. O., Coelho, P., Witek, L., Benalcázar Jalkh, E. B., Gênova, L. A., Monteiro, K. N., Cesar, P. F., Lisboa Filho, P. N., Bergamo, E. T. P., Ramalho, I. S. & Bonfante, E. A., Jan 1 2019, In : Ceramics International.

Research output: Contribution to journal › Article

Aluminum Oxide
Zirconia
Alumina
Aging of materials
Composite materials

Osteogenic parameters surrounding trabecular tantalum metal implants in osteotomies prepared via osseodensification drilling

Witek, L., Alifarag, A. M., Tovar, N., Lopez, C. D., Gil, L. F., Gorbon-Osov, M., Hannan, K., Neiva, R. & Coelho, P. G., Nov 2019, In : Medicina Oral Patologia Oral y Cirugia Bucal. 24, 6, p. e764-e769 23108.

Research output: Contribution to journal › Article

Open Access
Tantalum
Osteotomy
Metals
Bone and Bones
Osseointegration

Osteointegrative and microgeometric comparison between micro-blasted and alumina blasting/acid etching on grade II and V titanium alloys (Ti-6Al-4V)

Granato, R., Bonfante, E. A., Castellano, A., Khan, R., Jimbo, R., Marin, C., Morsi, S., Witek, L. & Coelho, P., Sep 1 2019, In : Journal of the Mechanical Behavior of Biomedical Materials. 97, p. 288-295 8 p.

Research output: Contribution to journal › Article

Aluminum Oxide
Blasting
Titanium alloys
Etching
Alumina

Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix

He, L., Zhou, J., Chen, M., Lin, C. S., Kim, S. G., Zhou, Y., Xiang, L., Xie, M., Bai, H., Yao, H., Shi, C., Coelho, P., Bromage, T., Hu, B., Tovar, N., Witek, L., Wu, J., Chen, K., Gu, W., Zheng, J. & 28 others, Sheu, T. J., Zhong, J., Wen, J., Niu, Y., Cheng, B., Gong, Q., Owens, D. M., Stanislauskas, M., Pei, J., Chotkowski, G., Wang, S., Yang, G., Zegarelli, D. J., Shi, X., Finkel, M., Zhang, W., Li, J., Cheng, J., Tarnow, D. P., Zhou, X., Wang, Z., Jiang, X., Romanov, A., Rowe, D. W., Wang, S., Ye, L., Ling, J. & Mao, J., Jun 1 2019, In : Nature Materials. 18, 6, p. 627-637 11 p.

Research output: Contribution to journal › Article

Tissue regeneration
teeth
regeneration
organs
Vascular Endothelial Growth Factor A

Periodontal Tissue Regeneration Using Brain-Derived Neurotrophic Factor Delivered by Collagen Sponge

Ramalho, I., Bergamo, E., Lopes, A., Medina-Cintrón, C., Neiva, R., Witek, L. & Coelho, P., Aug 1 2019, In : Tissue Engineering - Part A. 25, 15-16, p. 1072-1083 12 p.

Research output: Contribution to journal › Article

Tissue regeneration
Brain-Derived Neurotrophic Factor
Porifera
Collagen
Regeneration

Physical and chemical characterization of synthetic bone mineral ink for robocasting applications

Eckstein, D., Rivera, C., Mijares, D., Coelho, P. & Witek, L., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ink
Minerals
Bone
Bone and Bones
Grafts

Regeneration of a Pediatric Alveolar Cleft Model Using Three-Dimensionally Printed Bioceramic Scaffolds and Osteogenic Agents: Comparison of Dipyridamole and rhBMP-2

Lopez, C. D., Coelho, P., Witek, L., Torroni, A., Greenberg, M. I., Cuadrado, D. L., Guarino, A. M., Bekisz, J. M., Cronstein, B. N. & Flores, R. L., Aug 1 2019, In : Plastic and reconstructive surgery. 144, 2, p. 358-370 13 p.

Research output: Contribution to journal › Article

Dipyridamole
Regeneration
Pediatrics
Bone and Bones
Sutures

Repair of Critical-Sized Long Bone Defects Using Dipyridamole-Augmented 3D-Printed Bioactive Ceramic Scaffolds

Witek, L., Alifarag, A. M., Tovar, N., Lopez, C. D., Cronstein, B. N., Rodriguez, E. D. & Coelho, P., Jan 1 2019, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journal › Article

Dipyridamole
Ceramics
Bone and Bones
X-Ray Microtomography
Bone Development

Ridge Architecture Preservation Following Minimally Traumatic Exodontia Techniques and Guided Tissue Regeneration

Faciola Pessôa de Oliveira, P. G., Pedroso Bergamo, E. T., Bordin, D., Arbex, L., Konrad, D., Gil, L. F., Neiva, R., Tovar, N., Witek, L. & Coelho, P. G., Aug 1 2019, In : Implant dentistry. 28, 4, p. 319-328 10 p.

Research output: Contribution to journal › Article

Guided Tissue Regeneration
Osteogenesis
Polytetrafluoroethylene
Tooth Extraction
Membranes

The effect of platelet-rich fibrin exudate addition to porous poly(lactic-co-glycolic acid) scaffold in bone healing: An in vivo study

Witek, L., Tian, H., Tovar, N., Torroni, A., Neiva, R., Gil, L. F. & Coelho, P., Jan 1 2019, (Accepted/In press) In : Journal of Biomedical Materials Research - Part B Applied Biomaterials.

Research output: Contribution to journal › Article

Platelets
Fibrin
Scaffolds
Bone
Acids

Zirconia-reinforced lithium silicate crowns: Effect of thickness on survival and failure mode

Bergamo, E. T. P., Bordin, D., Ramalho, I. S., Lopes, A. C. O., Gomes, R. S., Kaizer, M., Witek, L., Bonfante, E. A., Coelho, P. & Del Bel Cury, A. A., Jan 1 2019, In : Dental Materials.

Research output: Contribution to journal › Article

Silicates
Crowns
Lithium
Zirconia
Failure modes
2018

Effect of CAD/CAM Abutment Height and Cement Type on the Retention of Zirconia Crowns

Silva, C. E. P., Soares, S., Machado, C. M., Bergamo, E. T. P., Coelho, P., Witek, L., Ramalho, I. S., Jalkh, E. B. B. & Bonfante, E. A., Oct 1 2018, In : Implant dentistry. 27, 5, p. 582-587 6 p.

Research output: Contribution to journal › Article

Resin Cements
Computer-Aided Design
Crowns
Glass Ionomer Cements
Adhesives

Effect of implant placement depth on the peri-implant bone defect configurations in ligature-induced peri-implantitis: An experimental study in dogs

Huang, B., Zhang, L., Xu, L., Zhu, W., Witek, L., Tovar, N., Coelho, P. & Meng, H., Jan 20 2018, In : Medicina Oral Patologia Oral y Cirugia Bucal. 23, 1, p. e30-e37 22032.

Research output: Contribution to journal › Article

Peri-Implantitis
Ligation
Dogs
Bone and Bones
Alveolar Bone Loss

Form and functional repair of long bone using 3D-printed bioactive scaffolds

Tovar, N., Witek, L., Atria, P., Sobieraj, M., Bowers, M., Lopez, C. D., Cronstein, B. N. & Coelho, P., Jan 1 2018, (Accepted/In press) In : Journal of Tissue Engineering and Regenerative Medicine.

Research output: Contribution to journal › Article

Scaffolds
Bone
Repair
Bone and Bones
Defects

In vivo evaluation of resorbable supercritical CO2-treated collagen membranes for class III furcation-guided tissue regeneration

Tovar, N., Witek, L., Neiva, R., Marão, H. F., Gil, L. F., Atria, P., Jimbo, R., Caceres, E. A. & Coelho, P., Jan 1 2018, (Accepted/In press) In : Journal of Biomedical Materials Research - Part B Applied Biomaterials.

Research output: Contribution to journal › Article

Tissue regeneration
Collagen
Membranes
Defects
Thermogravimetric analysis

Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing

Lopez, C. D., Bekisz, J. M., Corciulo, C., Mediero, A., Coelho, P., Witek, L., Flores, R. L. & Cronstein, B. N., Jan 1 2018, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Contribution to journal › Article

Purinergic P1 Receptor Agonists
Bone Regeneration
Purinergic P1 Receptors
Adenosine
Bone and Bones

Osseodensification outperforms conventional implant subtractive instrumentation: A study in sheep

Oliveira, P. G. F. P. D., Bergamo, E. T. P., Neiva, R., Bonfante, E. A., Witek, L., Tovar, N. & Coelho, P., Sep 1 2018, In : Materials Science and Engineering C. 90, p. 300-307 8 p.

Research output: Contribution to journal › Article

sheep
drilling
Bone
Drilling
bones

Temporal osseointegration: Early biomechanical stability through osseodensification

Alifarag, A. M., Lopez, C. D., Neiva, R. F., Tovar, N., Witek, L. & Coelho, P., Jan 1 2018, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journal › Article

Osseointegration
Bone and Bones
Metals
Torque
Osteotomy

The Effect of CAD/CAM Crown Material and Cement Type on Retention to Implant Abutments

Lopes, A. C. D. O., Machado, C. M., Bonjardim, L. R., Bergamo, E. T. P., Ramalho, I. S., Witek, L., Coelho, P. & Bonfante, E. A., Jan 1 2018, (Accepted/In press) In : Journal of Prosthodontics.

Research output: Contribution to journal › Article

Computer-Aided Design
Resin Cements
Crowns
Cementation
Titanium

The effect of DLC-coating deposition method on the reliability and mechanical properties of abutment's screws

Bordin, D., Coelho, P., Bergamo, E. T. P., Bonfante, E. A., Witek, L. & Del Bel Cury, A. A., Jan 1 2018, (Accepted/In press) In : Dental Materials.

Research output: Contribution to journal › Article

Diamond
Diamonds
Carbon
Coatings
Mechanical properties

The effect of osseodensification drilling for endosteal implants with different surface treatments: A study in sheep

Lahens, B., Lopez, C. D., Neiva, R. F., Bowers, M. M., Jimbo, R., Bonfante, E. A., Morcos, J., Witek, L., Tovar, N. & Coelho, P., Jan 1 2018, (Accepted/In press) In : Journal of Biomedical Materials Research - Part B Applied Biomaterials.

Research output: Contribution to journal › Article

Surface treatment
Drilling
Bone
Acids
Animals

The role of 3D printing in treating craniomaxillofacial congenital anomalies

Lopez, C. D., Witek, L., Torroni, A., Flores, R. L., Demissie, D. B., Young, S., Cronstein, B. N. & Coelho, P., Aug 1 2018, In : Birth Defects Research. 110, 13, p. 1055-1064 10 p.

Research output: Contribution to journal › Review article

Printing
3D printers
Software
Skeleton
Defects

The Role of Adenosine Receptor Activation in Attenuating Cartilaginous Inflammation

Bekisz, J. M., Lopez, C. D., Corciulo, C., Mediero, A., Coelho, P., Witek, L., Flores, R. L. & Cronstein, B. N., Apr 14 2018, (Accepted/In press) In : Inflammation. p. 1-7 7 p.

Research output: Contribution to journal › Article

Purinergic P1 Receptors
Adenosine
Chondrocytes
Inflammation
Osteoarthritis

Three dimensionally printed bioactive ceramic scaffold osseoconduction across critical-sized mandibular defects

Lopez, C. D., Diaz-Siso, J. R., Witek, L., Bekisz, J. M., Cronstein, B. N., Torroni, A., Flores, R. L., Rodriguez, E. D. & Coelho, P., Mar 1 2018, In : Journal of Surgical Research. 223, p. 115-122 8 p.

Research output: Contribution to journal › Article

Ceramics
Bone and Bones
Mandible
Rabbits
Histology
2017

Biocompatibility and degradation properties of WE43 Mg alloys with and without heat treatment: In vivo evaluation and comparison in a cranial bone sheep model

Torroni, A., Xiang, C., Witek, L., Rodriguez, E. D., Coelho, P. & Gupta, N., 2017, (Accepted/In press) In : Journal of Cranio-Maxillofacial Surgery.

Research output: Contribution to journal › Article

Magnesium
Sheep
Hot Temperature
Bone and Bones
Osteogenesis

Controlling calcium and phosphate ion release of 3D printed bioactive ceramic scaffolds: An in vitro study

Witek, L., Shi, Y. & Smay, J., Jun 1 2017, In : Journal of Advanced Ceramics. 6, 2, p. 157-164 8 p.

Research output: Contribution to journal › Article

Scaffolds
Calcium
Phosphates
Ions
Durapatite

Dipyridamole enhances osteogenesis of three-dimensionally printed bioactive ceramic scaffolds in calvarial defects

Bekisz, J. M., Flores, R. L., Witek, L., Lopez, C. D., Runyan, C. M., Torroni, A., Cronstein, B. N. & Coelho, P., Jan 1 2017, (Accepted/In press) In : Journal of Cranio-Maxillofacial Surgery.

Research output: Contribution to journal › Article

Dipyridamole
Ceramics
Osteogenesis
Bone Regeneration
Collagen

In vivo evaluation of dual acid-etched and grit-blasted/acid-etched implants with identical macrogeometry in high-density bone

Jinno, Y., Jimbo, R., Tovar, N., Teixeira, H. S., Witek, L. & Coelho, P., Dec 1 2017, In : Implant Dentistry. 26, 6, p. 815-819 5 p.

Research output: Contribution to journal › Article

Bone Density
Bone and Bones
Acids
Osseointegration
Sheep

Osseodensification for enhancement of spinal surgical hardware fixation

Lopez, C. D., Alifarag, A. M., Torroni, A., Tovar, N., Diaz-Siso, J. R., Witek, L., Rodriguez, E. D. & Coelho, P., May 1 2017, In : Journal of the Mechanical Behavior of Biomedical Materials. 69, p. 275-281 7 p.

Research output: Contribution to journal › Article

Bone
Hardware
Drilling
Testing

Residual stress of porcelain-fused to zirconia 3-unit fixed dental prostheses measured by nanoindentation

Fardin, V. P., Bonfante, E. A., Coelho, P., Janal, M. N., Tovar, N., Witek, L., Bordin, D. & Bonfante, G., Jan 1 2017, (Accepted/In press) In : Dental Materials.

Research output: Contribution to journal › Article

Dental Prosthesis
Dental Porcelain
Dental prostheses
Porcelain
Nanoindentation

The technique for 3D printing patient-specific models for auricular reconstruction

Flores, R. L., Liss, H., Raffaelli, S., Humayun, A., Khouri, K. S., Coelho, P. & Witek, L., Jan 7 2017, (Accepted/In press) In : Journal of Cranio-Maxillofacial Surgery.

Research output: Contribution to journal › Article

Ear
Printing
Photography
Operating Rooms
Software
2016

Biomechanical and histologic basis of osseodensification drilling for endosteal implant placement in low density bone. An experimental study in sheep

Lahens, B., Neiva, R., Tovar, N., Alifarag, A. M., Jimbo, R., Bonfante, E. A., Bowers, M. M., Cuppini, M., Freitas, H., Witek, L. & Coelho, P., Oct 1 2016, In : Journal of the Mechanical Behavior of Biomedical Materials. 63, p. 56-65 10 p.

Research output: Contribution to journal › Article

Drilling
Bone
Densification
Animals
Torque

Fatigue Failure of Narrow Implants with Different Implant-Abutment Connection Designs

Bordin, D., Witek, L., Fardin, V. P., Bonfante, E. A. & Coelho, P., 2016, (Accepted/In press) In : Journal of Prosthodontics.

Research output: Contribution to journal › Article

Dental Implants
Fatigue
Incisor
Titanium
Crowns

Patient-specific 3D models for autogenous ear reconstruction

Witek, L., Khouri, K. S., Coelho, P. & Flores, R. L., Jan 1 2016, In : Plastic and Reconstructive Surgery - Global Open. 4, 10, e1093.

Research output: Contribution to journal › Comment/debate

Open Access
Ear

Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo via an adenosine-dependent mechanism

Mediero, A., Wilder, T., Reddy, V. S. R., Cheng, Q., Tovar, N., Coelho, P., Witek, L., Whatling, C. & Cronstein, B. N., Nov 1 2016, In : FASEB Journal. 30, 11, p. 3887-3900 14 p.

Research output: Contribution to journal › Article

Osteoblasts
Osteoclasts
Osteogenesis
Bone Regeneration
Adenosine
2015

Assessment of atmospheric pressure plasma treatment for implant osseointegration

Danna, N. R., Beutel, B. G., Tovar, N., Witek, L., Marin, C., Bonfante, E. A., Granato, R., Suzuki, M. & Coelho, P., 2015, In : BioMed Research International. 2015, 761718.

Research output: Contribution to journal › Article

Osseointegration
Atmospheric Pressure
Titanium
Atmospheric pressure
Plasmas

Bone regenerative potential of modified biphasic graft materials

Khan, R., Witek, L., Breit, M., Colon, D., Tovar, N., Janal, M. N., Jimbo, R. & Coelho, P., Apr 4 2015, In : Implant Dentistry. 24, 2, p. 149-154 6 p.

Research output: Contribution to journal › Article

Collagen
Transplants
Bone and Bones
Chemical Models
Osteogenesis

Geometrical versus random β-TCP scaffolds: Exploring the effects on Schwann cell growth and behavior

Sweet, L., Kang, Y., Czisch, C., Witek, L., Shi, Y., Smay, J., Plant, G. W. & Yang, Y., Oct 7 2015, In : PLoS One. 10, 10, e013982.

Research output: Contribution to journal › Article

Schwann cells
Schwann Cells
Cell growth
Scaffolds (biology)
Scaffolds

Influence of placement depth on bone remodeling around tapered internal connection implants: A histologic study in dogs

Huang, B., Meng, H., Zhu, W., Witek, L., Tovar, N. & Coelho, P., Aug 1 2015, In : Clinical Oral Implants Research. 26, 8, p. 942-949 8 p.

Research output: Contribution to journal › Article

Bone Remodeling
Dogs
Bone and Bones
Tooth Extraction
Mandible
2014

Amoxicillin administrations and its influence on bone repair around osseointegrated implants

Giro, G., In, J., Witek, L., Granato, R., Marin, C., Coelho, P., Ramacciato, J. C. & Lopes Motta, R. H., Feb 2014, In : Journal of Oral and Maxillofacial Surgery. 72, 2

Research output: Contribution to journal › Article

Amoxicillin
Bone and Bones
Suspensions
Osseointegration
Dental Implants

Development of a guided bone regeneration device using salicylic acid-poly(anhydride-ester) polymers and osteoconductive scaffolds

Mitchell, A., Kim, B., Cottrell, J., Snyder, S., Witek, L., Ricci, J., Uhrich, K. E. & Patrick O'Connor, J., Mar 2014, In : Journal of Biomedical Materials Research - Part A. 102, 3, p. 655-664 10 p.

Research output: Contribution to journal › Article

Salicylic acid
Salicylic Acid
Anhydrides
Scaffolds
Esters

Evaluation of bone response to various anorganic bovine bone xenografts: An experimental calvaria defect study

Tovar, N., Jimbo, R., Gangolli, R., Perez, L., Manne, L., Yoo, D., Lorenzoni, F., Witek, L. & Coelho, P., Feb 2014, In : International Journal of Oral and Maxillofacial Surgery. 43, 2, p. 251-260 10 p.

Research output: Contribution to journal › Article

Heterografts
Skull
Bone Substitutes
Transplants
Osteogenesis