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Lionel Christiaen

Associate Professor of Biology

    20022019
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    Research Output 2002 2019

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    Article
    2019

    A complete statistical model for calibration of RNA-seq counts using external spike-ins and maximum likelihood theory

    Athanasiadou, R., Neymotin, B., Brandt, N., Wang, W., Christiaen, L., Gresham, D. & Tranchina, D., Mar 1 2019, In : PLoS computational biology. 15, 3, p. e1006794

    Research output: Contribution to journalArticle

    Open Access
    Statistical Models
    statistical models
    RNA
    Spike
    Calibration

    A conserved regulatory program initiates lateral plate mesoderm emergence across chordates

    Prummel, K. D., Hess, C., Nieuwenhuize, S., Parker, H. J., Rogers, K. W., Kozmikova, I., Racioppi, C., Brombacher, E. C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M. H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M. & 2 others, Krumlauf, R. & Mosimann, C., Dec 1 2019, In : Nature Communications. 10, 1, 3857.

    Research output: Contribution to journalArticle

    Open Access
    Chordata
    Mesoderm
    Prednisolone
    Muscle
    Zebrafish

    A single-cell transcriptional roadmap for cardiopharyngeal fate diversification

    Wang, W., Niu, X., Stuart, T., Jullian, E., Mauck, W. M., Kelly, R. G., Satija, R. & Christiaen, L., Jun 1 2019, In : Nature Cell Biology. 21, 6, p. 674-686 13 p.

    Research output: Contribution to journalArticle

    Pharyngeal Muscles
    Chordata
    Head
    Muscles
    Mesoderm

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Racioppi, C., Wiechecki, K. A. & Christiaen, L., Nov 2019, In : eLife. 8, e49921.

    Research output: Contribution to journalArticle

    Open Access
    Pharyngeal Muscles
    Chromatin
    Muscle
    Mesoderm
    Gene expression

    Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

    Bernadskaya, Y. Y., Brahmbhatt, S., Gline, S. E., Wang, W. & Christiaen, L., Dec 1 2019, In : Nature Communications. 10, 1, 57.

    Research output: Contribution to journalArticle

    Cell-Matrix Junctions
    polarity
    adhesion
    Adhesion
    Light trailers

    Initial characterization of Wnt-Tcf functions during Ciona heart development

    Kaplan, N. A., Wang, W. & Christiaen, L., Jan 1 2019, (Accepted/In press) In : Developmental Biology.

    Research output: Contribution to journalArticle

    Wnt Signaling Pathway
    Pharyngeal Muscles
    Muscle Development
    Cardiac Myocytes
    Vertebrates
    2018

    An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

    Razy-Krajka, F., Gravez, B., Kaplan, N., Racioppi, C., Wang, W. & Christiaen, L., Feb 6 2018, In : eLife. 7, e29656.

    Research output: Contribution to journalArticle

    Mesoderm
    Muscle
    Siphons
    Muscles
    Networks (circuits)

    ANISEED 2017: Extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets

    Brozovic, M., Dantec, C., Dardaillon, J., Dauga, D., Faure, E., Gineste, M., Louis, A., Naville, M., Nitta, K. R., Piette, J., Reeves, W., Scornavacca, C., Simion, P., Vincentelli, R., Bellec, M., Aicha, S. B., Fagotto, M., Guéroult-Bellone, M., Haeussler, M., Jacox, E. & 19 others, Lowe, E. K., Mendez, M., Roberge, A., Stolfi, A., Yokomori, R., Brown, C. T., Cambillau, C., Christiaen, L., Delsuc, F., Douzery, E., Dumollard, R., Kusakabe, T., Nakai, K., Nishida, H., Satou, Y., Swalla, B., Veeman, M., Volff, J. N. & Lemaire, P., Jan 1 2018, In : Nucleic Acids Research. 46, D1, p. D718-D725

    Research output: Contribution to journalArticle

    Urochordata
    Genome
    Databases
    Gene Expression
    Vertebrates

    Transcriptional regulation of Rab32/38, a specific marker of pigment cell formation in Ciona robusta

    Racioppi, C., Coppola, U., Christiaen, L. & Ristoratore, F., Jan 1 2018, (Accepted/In press) In : Developmental Biology.

    Research output: Contribution to journalArticle

    Monophenol Monooxygenase
    Nucleic Acid Regulatory Sequences
    Pigmentation
    Vertebrates
    Binding Sites
    2017

    Evolutionary loss of melanogenesis in the tunicate Molgula occulta

    Racioppi, C., Valoroso, M. C., Coppola, U., Lowe, E. K., Brown, C. T., Swalla, B. J., Christiaen, L., Stolfi, A. & Ristoratore, F., Jul 18 2017, In : EvoDevo. 8, 1, 11.

    Research output: Contribution to journalArticle

    Molgula
    Molgula oculata
    melanogenesis
    Urochordata
    Monophenol Monooxygenase

    Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes

    Burguera, D., Marquez, Y., Racioppi, C., Permanyer, J., Torres-Méndez, A., Esposito, R., Albuixech-Crespo, B., Fanlo, L., D'Agostino, Y., Gohr, A., Navas-Perez, E., Riesgo, A., Cuomo, C., Benvenuto, G., Christiaen, L., Martí, E., D'Aniello, S., Spagnuolo, A., Ristoratore, F., Arnone, M. I. & 2 others, Garcia-Fernàndez, J. & Irimia, M., Dec 1 2017, In : Nature Communications. 8, 1, 1799.

    Research output: Contribution to journalArticle

    splicing
    Vertebrates
    vertebrates
    Animals
    Genes
    2016

    Evaluation and rational design of guide RNAs for efficient CRISPR/Cas9-mediated mutagenesis in Ciona

    Gandhi, S., Haeussler, M., Razy-Krajka, F., Christiaen, L. & Stolfi, A., Oct 6 2016, (Accepted/In press) In : Developmental Biology.

    Research output: Contribution to journalArticle

    Clustered Regularly Interspaced Short Palindromic Repeats
    Guide RNA
    Mutagenesis
    Embryonic Structures
    Urochordata

    Fused Regression for Multi-source Gene Regulatory Network Inference

    Lam, K. Y., Westrick, Z. M., Müller, C. L., Christiaen, L. & Bonneau, R., Dec 1 2016, In : PLoS Computational Biology. 12, 12, e1005157.

    Research output: Contribution to journalArticle

    Gene Regulatory Networks
    Gene Regulatory Network
    Genes
    Regression
    gene

    Rewiring of an ancestral Tbx1/10-Ebf-Mrf network for pharyngeal muscle specification in distinct embryonic lineages

    Tolkin, T. & Christiaen, L., Oct 15 2016, In : Development (Cambridge). 143, 20, p. 3852-3862 11 p.

    Research output: Contribution to journalArticle

    Pharyngeal Muscles
    Muscles
    Muscle Development
    Chordata
    Genes
    2015

    A new heart for a new head in vertebrate cardiopharyngeal evolution

    Diogo, R., Kelly, R. G., Christiaen, L., Levine, M., Ziermann, J. M., Molnar, J. L., Noden, D. M. & Tzahor, E., Apr 23 2015, In : Nature. 520, 7548, p. 466-473 8 p.

    Research output: Contribution to journalArticle

    Vertebrates
    Head
    Neural Crest
    Chordata
    Mesoderm

    Guidelines for the nomenclature of genetic elements in tunicate genomes

    Stolfi, A., Sasakura, Y., Chalopin, D., Satou, Y., Christiaen, L., Dantec, C., Endo, T., Naville, M., Nishida, H., Swalla, B. J., Volff, J. N., Voskoboynik, A., Dauga, D. & Lemaire, P., Jan 1 2015, In : Genesis. 53, 1, p. 1-14 14 p.

    Research output: Contribution to journalArticle

    Urochordata
    Terminology
    Genome
    Guidelines
    Vertebrates

    Migratory neuronal progenitors arise from the neural plate borders in tunicates

    Stolfi, A., Ryan, K., Meinertzhagen, I. A. & Christiaen, L., Nov 19 2015, In : Nature. 527, 7578, p. 371-374 4 p.

    Research output: Contribution to journalArticle

    Neural Plate
    Urochordata
    Neural Crest
    Vertebrates
    Neurons

    Regulation and evolution of cardiopharyngeal cell identity and behavior: Insights from simple chordates

    Kaplan, N., Razy-Krajka, F. & Christiaen, L., Jun 1 2015, In : Current Opinion in Genetics and Development. 32, p. 119-128 10 p.

    Research output: Contribution to journalArticle

    Chordata
    Pharyngeal Muscles
    Urochordata
    Vertebrates
    Myogenic Regulatory Factors

    Surrounding tissues canalize motile cardiopharyngeal progenitors towards collective polarity and directed migration

    Gline, S., Kaplan, N., Bernadskaya, Y., Abdu, Y. & Christiaen, L., Feb 1 2015, In : Development. 142, 3, p. 544-554 11 p.

    Research output: Contribution to journalArticle

    Ciona intestinalis
    Chordata
    Stereotyped Behavior
    Notochord
    Urochordata
    2014

    Collier/OLF/EBF-Dependent Transcriptional Dynamics Control Pharyngeal Muscle Specification from Primed Cardiopharyngeal Progenitors

    Razy-Krajka, F., Lam, K., Wang, W., Stolfi, A., Joly, M., Bonneau, R. & Christiaen, L., May 12 2014, In : Developmental Cell. 29, 3

    Research output: Contribution to journalArticle

    Pharyngeal Muscles
    Chordata
    Muscle
    Mesoderm
    Specifications

    Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians

    Stolfi, A., Lowe, E. K., Racioppi, C., Ristoratore, F., Brown, C. T., Swalla, B. J. & Christiaen, L., 2014, In : eLife. 3, p. e03728

    Research output: Contribution to journalArticle

    Urochordata
    Gene expression
    Assays
    Gene Expression
    Pharyngeal Muscles

    Fibroblast growth factor signalling controls nervous system patterning and pigment cell formation in Ciona intestinalis

    Racioppi, C., Kamal, A. K., Razy-Krajka, F., Gambardella, G., Zanetti, L., Di Bernardo, D., Sanges, R., Christiaen, L. & Ristoratore, F., 2014, In : Nature Communications. 5, 5830.

    Research output: Contribution to journalArticle

    Ciona intestinalis
    nervous system
    Fibroblast Growth Factors
    fibroblasts
    Neurology

    Tissue-specific genome editing in ciona embryos by CRISPR/Cas9

    Stolfi, A., Gandhi, S., Salek, F. & Christiaen, L., Nov 1 2014, In : Development. 141, 21, p. 4115-4120 6 p.

    Research output: Contribution to journalArticle

    Clustered Regularly Interspaced Short Palindromic Repeats
    Embryonic Structures
    Ciona intestinalis
    Genes
    Electroporation
    2013

    Cis-Regulatory Timers for Developmental Gene Expression

    Christiaen, L., 2013, In : PLoS Biology. 11, 10, e1001698.

    Research output: Contribution to journalArticle

    Developmental Genes
    timers
    Gene expression
    Genes
    Gene Expression

    NK4 Antagonizes Tbx1/10 to Promote Cardiac versus Pharyngeal Muscle Fate in the Ascidian Second Heart Field

    Wang, W., Razy-Krajka, F., Siu, E., Ketcham, A. & Christiaen, L., Dec 2013, In : PLoS Biology. 11, 12, e1001725.

    Research output: Contribution to journalArticle

    Pharyngeal Muscles
    Urochordata
    Ascidiacea
    Muscle
    heart

    p120RasGAP mediates ephrin/Eph-dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos

    Haupaix, N., Stolfi, A., Sirour, C., Picco, V., Levine, M., Christiaen, L. & Yasuo, H., Nov 1 2013, In : Development. 140, 21, p. 4347-4352 6 p.

    Research output: Contribution to journalArticle

    p120 GTPase Activating Protein
    ras GTPase-Activating Proteins
    Ephrins
    Urochordata
    Fibroblast Growth Factors
    2012

    Developmental cell behavior

    Christiaen, L., May 2012, In : Seminars in Cell and Developmental Biology. 23, 3, p. 289 1 p.

    Research output: Contribution to journalArticle

    Development and Evolution of the Ascidian Cardiogenic Mesoderm

    Tolkin, T. & Christiaen, L., 2012, In : Current Topics in Developmental Biology. 100, p. 107-142 36 p.

    Research output: Contribution to journalArticle

    Urochordata
    Mesoderm
    Chordata
    Vertebrates
    Ciona intestinalis

    Genetic and genomic toolbox of the Chordate Ciona intestinalis

    Stolfi, A. & Christiaen, L., Sep 1 2012, In : Genetics. 192, 1, p. 55-66 12 p.

    Research output: Contribution to journalArticle

    Ciona intestinalis
    Chordata
    Morpholinos
    Gene Transfer Techniques
    Electroporation

    Transcriptional Enhancers in Ascidian Development

    Wang, W. & Christiaen, L., 2012, In : Current Topics in Developmental Biology. 98, p. 147-172 26 p.

    Research output: Contribution to journalArticle

    Urochordata
    Chordata
    DNA
    Transfection
    Embryonic Structures
    2010

    A cis-regulatory signature for chordate anterior neuroectodermal genes

    Haeussler, M., Jaszczyszyn, Y., Christiaen, L. & Joly, J. S., Apr 2010, In : PLoS Genetics. 6, 4

    Research output: Contribution to journalArticle

    Chordata
    gene
    Genes
    Neural Plate
    regulatory sequences

    BMP signaling coordinates gene expression and cell migration during precardiac mesoderm development

    Christiaen, L., Stolfi, A. & Levine, M., Apr 2010, In : Developmental Biology. 340, 2, p. 179-187 9 p.

    Research output: Contribution to journalArticle

    Mesoderm
    Cell Movement
    Gene Expression
    Gene Regulatory Networks
    Cell Migration Inhibition

    Early chordate origins of the vertebrate second heart field

    Stolfi, A., Gainous, T. B., Young, J. J., Mori, A., Levine, M. & Christiaen, L., Jul 30 2010, In : Science. 329, 5991, p. 565-568 4 p.

    Research output: Contribution to journalArticle

    Chordata
    Vertebrates
    Muscles
    Ciona intestinalis
    Urochordata

    The ANISEED database: Digital representation, formalization, and elucidation of a chordate developmental program

    Tassy, O., Dauga, D., Daian, F., Sobral, D., Robin, F., Khoueiry, P., Salgado, D., Fox, V., Caillol, D., Schiappa, R., Laporte, B., Rios, A., Luxardi, G., Kusakabe, T., Joly, J. S., Darras, S., Christiaen, L., Contensin, M., Auger, H., Lamy, C. & 9 others, Hudson, C., Rothbächer, U., Gilchrist, M. J., Makabe, K. W., Hotta, K., Fujiwara, S., Satoh, N., Satou, Y. & Lemaire, P., Oct 2010, In : Genome Research. 20, 10, p. 1459-1468 10 p.

    Research output: Contribution to journalArticle

    Chordata
    Urochordata
    Developmental Biology
    Embryonic Structures
    Databases
    2009

    Electroporation of transgenic DNAs in the sea squirt Ciona

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Electroporation
    Oceans and Seas
    Plasmids
    Genes
    Tissue
    Cell Separation
    Sorting
    Oceans and Seas
    Flow Cytometry
    Embryonic Structures

    Isolation of sea squirt (Ciona) gametes, fertilization, dechorionation, and development

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Morpholinos
    Soaps (detergents)
    Fertilization
    Germ Cells
    Oceans and Seas

    Microinjection of morpholino oligos and RNAs in sea squirt (Ciona) embryos

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Morpholinos
    Microinjections
    Oceans and Seas
    RNA Splice Sites
    Embryonic Structures

    Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp

    Christiaen, L., Stolfi, A., Davidson, B. & Levine, M., Apr 15 2009, In : Developmental Biology. 328, 2, p. 552-560 9 p.

    Research output: Contribution to journalArticle

    Blastomeres
    Protein Isoforms
    Catenins
    Basic Helix-Loop-Helix Transcription Factors
    Morpholinos

    The sea squirt Ciona intestinalis

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Ciona intestinalis
    Oceans and Seas
    Vertebrates
    Genes
    Urochordata

    Whole-mount in situ hybridization on sea squirt (Ciona intestinalis) embryos

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Ciona intestinalis
    Gene expression
    Oceans and Seas
    In Situ Hybridization
    Embryonic Structures

    X-gal staining of electroporated sea squirt (Ciona) embryos

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Reporter Genes
    Oceans and Seas
    Larva
    Embryonic Structures
    Genes
    2008

    The transcription/migration interface in heart precursors of Ciona intestinalis

    Christiaen, L., Davidson, B., Kawashima, T., Powell, W., Nolla, H., Vranizan, K. & Levine, M., Jun 6 2008, In : Science. 320, 5881, p. 1349-1352 4 p.

    Research output: Contribution to journalArticle

    Ciona intestinalis
    Gene Regulatory Networks
    Cell Surface Extensions
    Forkhead Transcription Factors
    Urochordata
    2007

    Evolutionary modification of mouth position in deuterostomes

    Christiaen, L., Jaszczyszyn, Y., Kerfant, M., Kano, S., Thermes, V. & Joly, J. S., Aug 2007, In : Seminars in Cell and Developmental Biology. 18, 4, p. 502-511 10 p.

    Research output: Contribution to journalArticle

    Ectoderm
    Chordata
    Mouth
    Urochordata
    Embryonic Structures

    FoxF is essential for FGF-induced migration of heart progenitor cells in the ascidian Ciona intestinalis

    Beh, J., Shi, W., Levine, M., Davidson, B. & Christiaen, L., Sep 2007, In : Development. 134, 18, p. 3297-3305 9 p.

    Research output: Contribution to journalArticle

    Ciona intestinalis
    Urochordata
    Stem Cells
    Cell Movement
    Genetic Complementation Test
    2006

    FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis

    Davidson, B., Shi, W., Beh, J., Christiaen, L. & Levine, M., Oct 1 2006, In : Genes & development. 20, 19, p. 2728-2738 11 p.

    Research output: Contribution to journalArticle

    Ciona intestinalis
    Chordata
    Receptor Protein-Tyrosine Kinases
    Gastrulation
    Fibroblast Growth Factor Receptors

    Linking chordate gene networks to cellular behavior in ascidians

    Davidson, B. & Christiaen, L., Jan 27 2006, In : Cell. 124, 2, p. 247-250 4 p.

    Research output: Contribution to journalArticle

    Chordata
    Urochordata
    Gene Regulatory Networks
    Nucleic Acid Regulatory Sequences
    Redundancy
    2005

    A modular cis-regulatory system controls isoform-specific pitx expression in ascidian stomodæum

    Christiaen, L., Bourrat, F. & Joly, J. S., Jan 15 2005, In : Developmental Biology. 277, 2, p. 557-566 10 p.

    Research output: Contribution to journalArticle

    Urochordata
    Homeobox Genes
    Protein Isoforms
    Chordata
    Ciona intestinalis

    Embryonic versus blastogenetic development in the compound ascidian Botryllus schlosseri: Insights from Pitx expression patterns

    Tiozzo, S., Christiaen, L., Deyts, C., Manni, L., Joly, J. S. & Burighel, P., Feb 2005, In : Developmental Dynamics. 232, 2, p. 468-478 11 p.

    Research output: Contribution to journalArticle

    Developmental Genes
    Urochordata
    Embryonic Development
    Larva
    Chordata

    Regulatory gene expressions in the ascidian ventral sensory vesicle: Evolutionary relationships with the vertebrate hypothalamus

    Moret, F., Christiaen, L., Deyts, C., Blin, M., Vernier, P. & Joly, J. S., Jan 15 2005, In : Developmental Biology. 277, 2, p. 567-579 13 p.

    Research output: Contribution to journalArticle

    Urochordata
    Regulator Genes
    Hypothalamus
    Vertebrates
    Prosencephalon