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Kirsten Sadler Edepli

Associate Professor of Biology

    1992 …2019

    Research output per year

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    Research Output

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    Article
    2019

    Epigenetic Compensation Promotes Liver Regeneration

    Wang, S., Zhang, C., Hasson, D., Desai, A., SenBanerjee, S., Magnani, E., Ukomadu, C., Lujambio, A., Bernstein, E. & Sadler, K. C., Jul 1 2019, In : Developmental Cell. 50, 1, p. 43-56.e6

    Research output: Contribution to journalArticle

    Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots

    Benyettou, F., Prakasam, T., Ramdas Nair, A., Witzel, I. I., Alhashimi, M., Skorjanc, T., Olsen, J. C., Sadler, K. C. & Trabolsi, A., Jun 21 2019, In : Chemical Science. 10, 23, p. 5884-5892 9 p.

    Research output: Contribution to journalArticle

    Open Access
    2018

    High resolution annotation of zebrafish transcriptome using long-read sequencing

    Nudelman, G., Frasca, A., Kent, B., Sadler, K. C., Sealfon, S. C., Walsh, M. J. & Zaslavsky, E., Sep 2018, In : Genome Research. 28, 9, p. 1415-1425 11 p.

    Research output: Contribution to journalArticle

    Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish

    Bambino, K., Zhang, C., Austin, C., Amarasiriwardena, C., Arora, M., Chu, J. & Sadler, K. C., Feb 26 2018, In : Disease models & mechanisms. 11, 2

    Research output: Contribution to journalArticle

    2017

    Loss of dna methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling

    Chernyavskaya, Y., Mudbhary, R., Zhang, C., Tokarz, D., Jacob, V., Gopinath, S., Sun, X., Wang, S., Magnani, E., Madakashira, B. P., Yoder, J. A., Hoshida, Y. & Sadler, K. C., Aug 15 2017, In : Development (Cambridge). 144, 16, p. 2925-2939 15 p.

    Research output: Contribution to journalArticle

    MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

    Shtraizent, N., DeRossi, C., Nayar, S., Sachidanandam, R., Katz, L. S., Prince, A., Koh, A. P., Vincek, A., Hadas, Y., Hoshida, Y., Scott, D. K., Eliyahu, E., Freeze, H. H., Sadler, K. C. & Chu, J., Jun 23 2017, In : eLife. 6, e22477.

    Research output: Contribution to journalArticle

    Variant Histone H2afv reprograms DNA methylation during early zebrafish development

    Madakashira, B., Corbett, L., Zhang, C., Paoli, P., Casement, J. W., Mann, J., Sadler, K. C. & Mann, D. A., Sep 2 2017, In : Epigenetics. 12, 9, p. 811-824 14 p.

    Research output: Contribution to journalArticle

    2016

    Comparative epigenomic profiling of the DNA methylome in mouse and Zebrafish uncovers high interspecies divergence

    Zhang, C., Hoshida, Y. & Sadler, K. C., Jun 17 2016, In : Frontiers in Genetics. 7, JUN, 110.

    Research output: Contribution to journalArticle

    Trappc11 is required for protein glycosylation in zebrafish and humans

    DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imriea, D., Nayar, S., Baryshnikova, A., Milev, M. P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H. H., Lehrman, M. A., Sacher, M. & Sadler, K. C., Apr 15 2016, In : Molecular biology of the cell. 27, 8, p. 1220-1234 15 p.

    Research output: Contribution to journalArticle

    UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development

    Kent, B., Magnani, E., Walsh, M. J. & Sadler, K. C., Apr 1 2016, In : Developmental Biology. 412, 1, p. 99-113 15 p.

    Research output: Contribution to journalArticle

    2015

    Dna hypomethylation induces a dna replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos

    Jacob, V., Chernyavskaya, Y., Chen, X., Tan, P. S., Kent, B., Hoshida, Y. & Sadler, K. C., Feb 1 2015, In : Development (Cambridge). 142, 3, p. 510-521 12 p.

    Research output: Contribution to journalArticle

    2014

    Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

    Howarth, D. L., Lindtner, C., Vacaru, A. M., Sachidanandam, R., Tsedensodnom, O., Vasilkova, T., Buettner, C. & Sadler, K. C., May 2014, In : PLoS genetics. 10, 5, e1004335.

    Research output: Contribution to journalArticle

    In vivo cell biology in zebrafish - providing insights into vertebrate development and disease

    Vacaru, A. M., Unlu, G., Spitzner, M., Mione, M., Knapik, E. W. & Sadler, K. C., Feb 1 2014, In : Journal of Cell Science. 127, 3, p. 485-495 11 p.

    Research output: Contribution to journalArticle

    MKKing the most of liver regeneration: An in vivo screen identifies the MKK4 pathway as a suppressor of regeneration

    Jacob, V. & Sadler, K. C., Mar 1 2014, In : Hepatology. 59, 3, p. 1201-1203 3 p.

    Research output: Contribution to journalArticle

    Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish

    Vacaru, A. M., Di Narzo, A. F., Howarth, D. L., Tsedensodnom, O., Imrie, D., Cinaroglu, A., Amin, S., Hao, K. & Sadler, K. C., Jul 2014, In : DMM Disease Models and Mechanisms. 7, 7, p. 823-835 13 p.

    Research output: Contribution to journalArticle

    RAF1 mutations in childhood-onset dilated cardiomyopathy

    Dhandapany, P. S., Razzaque, M. A., Muthusami, U., Kunnoth, S., Edwards, J. J., Mulero-Navarro, S., Riess, I., Pardo, S., Sheng, J., Rani, D. S., Rani, B., Govindaraj, P., Flex, E., Yokota, T., Furutani, M., Nishizawa, T., Nakanishi, T., Robbins, J., Limongelli, G., Hajjar, R. J. & 9 others, Lebeche, D., Bahl, A., Khullar, M., Rathinavel, A., Sadler, K. C., Tartaglia, M., Matsuoka, R., Thangaraj, K. & Gelb, B. D., Jun 2014, In : Nature Genetics. 46, 6, p. 635-639 5 p.

    Research output: Contribution to journalArticle

    UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma

    Mudbhary, R., Hoshida, Y., Chernyavskaya, Y., Jacob, V., Villanueva, A., Fiel, M. I., Chen, X., Kojima, K., Thung, S., Bronson, R. T., Lachenmayer, A., Revill, K., Alsinet, C., Sachidanandam, R., Desai, A., SenBanerjee, S., Ukomadu, C., Llovet, J. M. & Sadler, K. C., Feb 10 2014, In : Cancer Cell. 25, 2, p. 196-209 14 p.

    Research output: Contribution to journalArticle

    2013

    A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation

    Chu, J., Mir, A., Gao, N., Rosa, S., Monson, C., Sharma, V., Steet, R., Freeze, H. H., Lehrman, M. A. & Sadler, K. C., Jan 1 2013, In : DMM Disease Models and Mechanisms. 6, 1, p. 95-105 11 p.

    Research output: Contribution to journalArticle

    Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae

    Howarth, D. L., Yin, C., Yeh, K. & Sadler, K. C., Jun 1 2013, In : Zebrafish. 10, 2, p. 199-210 12 p.

    Research output: Contribution to journalArticle

    Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease

    Tsedensodnom, O., Vacaru, A. M., Howarth, D. L., Yin, C. & Sadler, K. C., Sep 1 2013, In : DMM Disease Models and Mechanisms. 6, 5, p. 1213-1226 14 p.

    Research output: Contribution to journalArticle

    Models of transparency

    Heath, J. K., Langenau, D., Sadler, K. C. & White, R., Apr 1 2013, In : Scientist. 27, 4

    Research output: Contribution to journalArticle

    ROS: Redux and paradox in fatty liver disease

    Tsedensodnom, O. & Sadler, K. C., Oct 1 2013, In : Hepatology. 58, 4, p. 1210-1212 3 p.

    Research output: Contribution to journalArticle

    2012

    Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes

    Howarth, D. L., Vacaru, A. M., Tsedensodnom, O., Mormone, E., Nieto, N., Costantini, L. M., Snapp, E. L. & Sadler, K. C., Jan 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 1, p. 14-23 10 p.

    Research output: Contribution to journalArticle

    A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency

    Cline, A., Gao, N., Flanagan-Steet, H., Sharma, V., Rosa, S., Sonon, R., Azadi, P., Sadler, K. C., Freeze, H. H., Lehrman, M. A. & Steet, R., Nov 1 2012, In : Molecular biology of the cell. 23, 21, p. 4175-4187 13 p.

    Research output: Contribution to journalArticle

    The Cx43-like connexin protein Cx40.8 is differentially localized during fin ontogeny and fin regeneration

    Gerhart, S. V., Eble, D. M., Burger, R. M., Oline, S. N., Vacaru, A., Sadler, K. C., Jefferis, R. & Iovine, M. K., Feb 8 2012, In : PloS one. 7, 2, e31364.

    Research output: Contribution to journalArticle

    UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis

    Chua, J., Loughlin, E. A., Gaur, N. A., SenBanerjee, S., Jacob, V., Monson, C., Kent, B., Oranu, A., Ding, Y., Ukomadu, C. & Sadler, K. C., Jan 1 2012, In : Molecular biology of the cell. 23, 1, p. 59-70 12 p.

    Research output: Contribution to journalArticle

    2011

    Drinks Like a Fish: Using Zebrafish to Understand Alcoholic Liver Disease

    Howarth, D. L., Passeri, M. & Sadler, K. C., May 1 2011, In : Alcoholism: Clinical and Experimental Research. 35, 5, p. 826-829 4 p.

    Research output: Contribution to journalArticle

    Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish

    Thakur, P. C., Stuckenholz, C., Rivera, M. R., Davison, J. M., Yao, J. K., Amsterdam, A., Sadler, K. C. & Bahary, N., Aug 1 2011, In : Hepatology. 54, 2, p. 452-462 11 p.

    Research output: Contribution to journalArticle

    UHRF1 depletion causes a G 2/M arrest, activation of DNA damage response and apoptosis

    Tien, A. L., Senbanerjee, S., Kulkarni, A., Mudbhary, R., Goudreau, B., Ganesan, S., Sadler, K. C. & Ukomadu, C., Apr 1 2011, In : Biochemical Journal. 435, 1, p. 175-185 11 p.

    Research output: Contribution to journalArticle

    2010

    Conservation and divergence of methylation patterning in plants and animals

    Feng, S., Cokus, S. J., Zhang, X., Chen, P. Y., Bostick, M., Goll, M. G., Hetzel, J., Jain, J., Strauss, S. H., Halpern, M. E., Ukomadu, C., Sadler, K. C., Pradhan, S., Pellegrini, M. & Jacobsen, S. E., May 11 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 19, p. 8689-8694 6 p.

    Research output: Contribution to journalArticle

    Inbreeding depression and outbreeding depression are evident in wild-type zebrafish lines

    Monson, C. A. & Sadler, K. C., Jun 1 2010, In : Zebrafish. 7, 2, p. 189-197 9 p.

    Research output: Contribution to journalArticle

    Klf6/copeb is required for hepatic outgrowth in zebrafish and for hepatocyte specification in mouse ES cells

    Zhao, X., Monson, C., Gao, C., Gouon-Evans, V., Matsumoto, N., Sadler, K. C. & Friedman, S. L., Aug 1 2010, In : Developmental Biology. 344, 1, p. 79-93 15 p.

    Research output: Contribution to journalArticle

    White adipose tissue development in zebrafish is regulated by both developmental time and fish size

    Imrie, D. & Sadler, K. C., Nov 1 2010, In : Developmental Dynamics. 239, 11, p. 3013-3023 11 p.

    Research output: Contribution to journalArticle

    2009

    A zebrafish retinal graded photochemical stress model

    Eichenbaum, J. W., Cinaroglu, A., Eichenbaum, K. D. & Sadler, K. C., May 1 2009, In : Journal of Pharmacological and Toxicological Methods. 59, 3, p. 121-127 7 p.

    Research output: Contribution to journalArticle

    Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation

    Passeri, M. J., Cinaroglu, A., Gao, C. & Sadler, K. C., Jun 24 2009, In : Hepatology. 49, 2, p. 443-452 10 p.

    Research output: Contribution to journalArticle

    2008

    Endothelial Signals Modulate Hepatocyte Apicobasal Polarization in Zebrafish

    Sakaguchi, T. F., Sadler, K. C., Crosnier, C. & Stainier, D. Y. R., Oct 28 2008, In : Current Biology. 18, 20, p. 1565-1571 7 p.

    Research output: Contribution to journalArticle

    The role of insulin receptor signaling in zebrafish embryogenesis

    Toyoshima, Y., Monson, C., Duan, C., Wu, Y., Gao, C., Yakar, S., Sadler, K. C. & LeRoith, D., Dec 1 2008, In : Endocrinology. 149, 12, p. 5996-6005 10 p.

    Research output: Contribution to journalArticle

    2007

    Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1

    Sadler, K. C., Krahn, K. N., Gaur, N. A. & Ukomadu, C., Jan 30 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 5, p. 1570-1575 6 p.

    Research output: Contribution to journalArticle

    2005

    A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease

    Sadler, K. C., Amsterdam, A., Soroka, C., Boyer, J. & Hopkins, N., Aug 1 2005, In : Development. 132, 15, p. 3561-3572 12 p.

    Research output: Contribution to journalArticle

    Cryopreservation of starfish oocytes

    Hamaratoǧlu, F., Eroǧlu, A., Toner, M. & Sadler, K. C., Feb 2005, In : Cryobiology. 50, 1, p. 38-47 10 p.

    Research output: Contribution to journalArticle

    2004

    Many ribosomal protein genes are cancer genes in zebrafish

    Amsterdam, A., Sadler, K. C., Lai, K., Farrington, S., Bronson, R. T., Lees, J. A. & Hopkins, N., Sep 27 2004, In : PLoS biology. 2, 5

    Research output: Contribution to journalArticle

    MAP Kinases Regulate Unfertilized Egg Apoptosis and Fertilization Suppresses Death Via Ca2+ Signaling

    Sadler, K. C., Yüce, Ö., Hamaratoǧlu, F., Vergé, V., Peaucellier, G. & Picard, A., Mar 1 2004, In : Molecular Reproduction and Development. 67, 3, p. 366-383 18 p.

    Research output: Contribution to journalArticle

    2001

    Postmeiotic unfertilized starfish eggs die by apoptosis

    Yuce, O. & Sadler, K. C., Sep 1 2001, In : Developmental Biology. 237, 1, p. 29-44 16 p.

    Research output: Contribution to journalArticle

    Starfish oocytes form intracellular ice at unusually high temperatures

    Köseolu, M., Erolu, A., Toner, M. & Sadler, K. C., Nov 2001, In : Cryobiology. 43, 3, p. 248-259 12 p.

    Research output: Contribution to journalArticle

    2000

    Orchestrating cell division

    Sadler, K. C. & Do Carmo Avides, M., Oct 1 2000, In : Trends in Cell Biology. 10, 10, p. 447-450 4 p.

    Research output: Contribution to journalArticle

    1998

    Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes

    Sadler, K. C. & Ruderman, J. V., May 1 1998, In : Developmental Biology. 197, 1, p. 25-38 14 p.

    Research output: Contribution to journalArticle

    1993

    Membrane Glycolipid Trafficking in Living, Polarized Pancreatic Acinar Cells: Assessment by Confocal Microscopy

    Cornell-Bell, A. H., Otake, L. R., Sadler, K., Thomas, P. G., Lawrence, S., Olsen, K., Gumkowski, F., Peterson, J. R. & Jamieson, J. D., Jan 1 1993, In : Methods in Cell Biology. 38, C, p. 221-240 20 p.

    Research output: Contribution to journalArticle

    1992

    A novel peptide-producing cell in Xenopus: Multinucleated gastric mucosal cell strikingly similar to the granular gland of the skin

    Moore, K. S., Bevins, C. L., Tomassini, N., Huttner, K. M., Sadler, K., Moreira, J. E., Reynolds, J. & Zasloff, M., Jan 1 1992, In : Journal of Histochemistry and Cytochemistry. 40, 3, p. 367-378 12 p.

    Research output: Contribution to journalArticle

    Localization of xenopsin and xenopsin precursor fragment immunoreactivities in the skin and gastrointestinal tract of Xenopus laevis

    Sadler, K. C., Bevins, C. L. & Kaltenbach, J. C., Nov 1 1992, In : Cell & Tissue Research. 270, 2, p. 257-263 7 p.

    Research output: Contribution to journalArticle