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Gordon Fishell

Co-Principal Investigator

    1987 …2019
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    Research Output 1987 2019

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    2019

    Activity of Prefrontal Neurons Predict Future Choices during Gambling

    Passecker, J., Mikus, N., Malagon-Vina, H., Anner, P., Dimidschstein, J., Fishell, G., Dorffner, G. & Klausberger, T., Jan 2 2019, In : Neuron. 101, 1, p. 152-164.e7

    Research output: Contribution to journalArticle

    Gambling
    Risk-Taking
    Neurons

    Four unique interneuron populations reside in neocortical layer 1

    Schuman, B., Machold, R. P., Hashikawa, Y., Fuzik, J., Fishell, G. & Rudy, B., Jan 2 2019, In : Journal of Neuroscience. 39, 1, p. 125-139 15 p.

    Research output: Contribution to journalArticle

    Interneurons
    Pyramidal Cells
    Population
    Electrophysiology
    Dendrites

    Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons

    McKenzie, M. G., Cobbs, L. V., Dummer, P. D., Petros, T. J., Halford, M. M., Stacker, S. A., Zou, Y., Fishell, G. & Au, E., Sep 4 2019, In : Neuron. 103, 5, p. 853-864.e4

    Research output: Contribution to journalArticle

    Parvalbumins
    Interneurons
    Somatostatin
    Median Eminence
    Wnt Receptors

    Preserving Inhibition during Developmental Hearing Loss Rescues Auditory Learning and Perception

    Mowery, T. M., Caras, M. L., Hassan, S. I., Wang, D. J., Dimidschstein, J., Fishell, G. & Sanes, D. H., Oct 16 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 42, p. 8347-8361 15 p.

    Research output: Contribution to journalArticle

    Auditory Perception
    Hearing Loss
    Learning
    GABA Uptake Inhibitors
    Inhibitory Postsynaptic Potentials
    2018

    Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism

    Priya, R., Paredes, M. F., Karayannis, T., Yusuf, N., Liu, X., Jaglin, X., Graef, I., Alvarez-Buylla, A. & Fishell, G., Feb 13 2018, In : Cell Reports. 22, 7, p. 1695-1709 15 p.

    Research output: Contribution to journalArticle

    Calcineurin
    Interneurons
    Cell death
    Cell Death
    Phosphoprotein Phosphatases

    Developmental diversification of cortical inhibitory interneurons

    Mayer, C., Hafemeister, C., Bandler, R. C., Machold, R., Batista Brito, R., Jaglin, X., Allaway, K., Butler, A., Fishell, G. & Satija, R., Mar 22 2018, In : Nature. 555, 7697, p. 457-462 6 p.

    Research output: Contribution to journalArticle

    Interneurons
    Transcription Factors
    RNA Sequence Analysis
    Parvalbumins
    Gene Regulatory Networks

    Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon

    Godbole, G., Shetty, A. S., Roy, A., D’Souza, L., Chen, B., Miyoshi, G., Fishell, G. & Tole, S., Jan 1 2018, In : Development (Cambridge). 145, 1, dev154583.

    Research output: Contribution to journalArticle

    Telencephalon
    Prosencephalon
    Genes

    Layer I Interneurons Sharpen Sensory Maps during Neonatal Development

    Che, A., Babij, R., Iannone, A. F., Fetcho, R. N., Ferrer, M., Liston, C., Fishell, G. & De Marco García, N. V., Jan 1 2018, (Accepted/In press) In : Neuron.

    Research output: Contribution to journalArticle

    Interneurons
    Vibrissae
    Serotonin Receptors
    Calcium
    Sensory Deprivation

    Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons

    Wamsley, B., Jaglin, X. H., Favuzzi, E., Quattrocolo, G., Nigro, M. J., Yusuf, N., Khodadadi-Jamayran, A., Rudy, B. & Fishell, G., Nov 21 2018, In : Neuron. 100, 4, p. 846-859 14 p.

    Research output: Contribution to journalArticle

    Interneurons
    Alternative Splicing
    Parvalbumins
    Somatostatin
    Messenger RNA
    2017

    FGF-dependent, context-driven role for FRS adapters in the early telencephalon

    Nandi, S., Gutin, G., Blackwood, C. A., Kamatkar, N. G., Lee, K. W., Fishell, G., Wang, F., Goldfarb, M. & Hébert, J. M., Jun 7 2017, In : Journal of Neuroscience. 37, 23, p. 5690-5698 9 p.

    Research output: Contribution to journalArticle

    Fibroblast Growth Factor Receptors
    Telencephalon
    Median Eminence
    Transducers
    Lateral Ventricles

    GABAergic Neurons in Ferret Visual Cortex Participate in Functionally Specific Networks

    Wilson, D. E., Smith, G. B., Jacob, A. L., Walker, T., Dimidschstein, J., Fishell, G. & Fitzpatrick, D., Mar 8 2017, In : Neuron. 93, 5, p. 1058-1065.e4

    Research output: Contribution to journalArticle

    GABAergic Neurons
    Ferrets
    Visual Cortex
    Neurons
    Primates

    Heterotopic Transplantations Reveal Environmental Influences on Interneuron Diversity and Maturation

    Quattrocolo, G., Fishell, G. & Petros, T. J., Oct 17 2017, In : Cell Reports. 21, 3, p. 721-731 11 p.

    Research output: Contribution to journalArticle

    Heterotopic Transplantation
    Interneurons
    Brain
    Cells
    Prosencephalon
    2016

    Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits

    Tuncdemir, S. N., Wamsley, B., Stam, F. J., Osakada, F., Goulding, M., Callaway, E. M., Rudy, B. & Fishell, G., Feb 3 2016, In : Neuron. 89, 3, p. 521-535 15 p.

    Research output: Contribution to journalArticle

    Interneurons
    Somatostatin
    Parvalbumins
    Pyramidal Cells

    Lineage Is a Poor Predictor of Interneuron Positioning within the Forebrain

    Mayer, C., Bandler, R. C. & Fishell, G., Oct 5 2016, In : Neuron. 92, 1, p. 45-51 7 p.

    Research output: Contribution to journalArticle

    Interneurons
    Prosencephalon
    Neurons
    Neurosciences
    Computer Simulation

    What is memory? The present state of the engram

    Poo, M. M., Pignatelli, M., Ryan, T. J., Tonegawa, S., Bonhoeffer, T., Martin, K. C., Rudenko, A., Tsai, L. H., Tsien, R. W., Fishell, G., Mullins, C., Gonçalves, J. T., Shtrahman, M., Johnston, S. T., Gage, F. H., Dan, Y., Long, J., Buzsáki, G. & Stevens, C., May 19 2016, In : BMC Biology. 14, 1, 40.

    Research output: Contribution to journalArticle

    zoologists
    Data storage equipment
    Biological Sciences
    outreach
    brain
    2015

    Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate

    Petros, T. J., Bultje, R. S., Ross, M. E., Fishell, G. & Anderson, S. A., Nov 10 2015, In : Cell Reports. 13, 6, p. 1090-1095 6 p.

    Research output: Contribution to journalArticle

    Neurogenesis
    Interneurons
    Parvalbumins
    Somatostatin
    Lateral Ventricles

    Clonally Related Forebrain Interneurons Disperse Broadly across Both Functional Areas and Structural Boundaries

    Mayer, C., Jaglin, X. H., Cobbs, L. V., Bandler, R. C., Streicher, C., Cepko, C. L., Hippenmeyer, S. & Fishell, G., Jan 1 2015, In : Neuron. 87, 5, p. 989-998 10 p.

    Research output: Contribution to journalArticle

    Interneurons
    Prosencephalon
    Median Eminence
    Stem Cells
    Globus Pallidus

    Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination

    Samanta, J., Grund, E. M., Silva, H. M., Lafaille, J. J., Fishell, G. & Salzer, J. L., Oct 15 2015, In : Nature. 526, 7573, p. 448-452 5 p.

    Research output: Contribution to journalArticle

    Neural Stem Cells
    Adult Stem Cells
    Lateral Ventricles
    Oligodendroglia
    Demyelinating Diseases

    MiRNAs are Essential for the Survival and Maturation of Cortical Interneurons

    Tuncdemir, S. N., Fishell, G. & Batista-Brito, R., Jan 1 2015, In : Cerebral Cortex. 25, 7, p. 1842-1857 16 p.

    Research output: Contribution to journalArticle

    Interneurons
    MicroRNAs
    Ribonuclease III
    Gene Expression Regulation
    Cell Movement

    Prox1 regulates the subtype-specific development of caudal ganglionic eminence-derived GABAergic cortical interneurons

    Miyoshi, G., Young, A., Petros, T., Karayannis, T., Chang, M. M. K., Lavado, A., Iwano, T., Nakajima, M., Taniguchi, H., Josh Huang, Z., Heintz, N., Oliver, G., Matsuzaki, F., Machold, R. P. & Fishell, G., Sep 16 2015, In : Journal of Neuroscience. 35, 37, p. 12869-12889 21 p.

    Research output: Contribution to journalArticle

    Interneurons
    Transcription Factors
    Cerebral Cortex

    Sensory inputs control the integration of neurogliaform interneurons into cortical circuits

    De Marco Garc�a, N. V., Priya, R., Tuncdemir, S. N., Fishell, G. & Karayannis, T., Mar 27 2015, In : Nature Neuroscience. 18, 3, p. 393-403 11 p.

    Research output: Contribution to journalArticle

    Interneurons
    Somatosensory Cortex
    N-Methyl-D-Aspartate Receptors
    Phenotype
    2014

    A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations

    Takada, N., Pi, H. J., Sousa, V. H., Waters, J., Fishell, G., Kepecs, A. & Osten, P., Jan 1 2014, In : Nature Communications. 5, 5333.

    Research output: Contribution to journalArticle

    Parvalbumins
    Interneurons
    Somatostatin
    Synchronization
    switches

    Astrocyte activation is suppressed in both normal and injured brain by FGF signaling

    Kang, W., Balordi, F., Su, N., Chen, L., Fishell, G. & Hébert, J. M., Jul 22 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 29

    Research output: Contribution to journalArticle

    Astrocytes
    Brain
    Neocortex
    Fibroblast Growth Factor Receptors
    Cicatrix

    Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission

    Karayannis, T., Au, E., Patel, J. C., Kruglikov, I., Markx, S., Delorme, R., Héron, D., Salomon, D., Glessner, J., Restituito, S., Gordon, A., Rodriguez-Murillo, L., Roy, N. C., Gogos, J. A., Rudy, B., Rice, M. E., Karayiorgou, M., Hakonarson, H., Keren, B., Huguet, G. & 5 others, Bourgeron, T., Hoeffer, C., Tsien, R. W., Peles, E. & Fishell, G., Jan 1 2014, In : Nature. 511, 7508, p. 236-240 5 p.

    Research output: Contribution to journalArticle

    Interneurons
    Synaptic Transmission
    Synapses
    Psychiatry
    Contactins

    Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning

    Sakamoto, M., Ieki, N., Miyoshi, G., Mochimaru, D., Miyachi, H., Imura, T., Yamaguchi, M., Fishell, G., Mori, K., Kageyama, R. & Imayoshi, I., Jan 1 2014, In : Journal of Neuroscience. 34, 17, p. 5788-5799 12 p.

    Research output: Contribution to journalArticle

    Olfactory Bulb
    Neurogenesis
    Learning
    Lateral Ventricles
    Neurons

    Reverse pharmacogenetic modulation of the nucleus accumbens reduces ethanol consumption in a limited access paradigm

    Cassataro, D., Bergfeldt, D., Malekian, C., Van Snellenberg, J. X., Thanos, P. K., Fishell, G. & Sjulson, L., Jan 1 2014, In : Neuropsychopharmacology. 39, 2, p. 283-290 8 p.

    Research output: Contribution to journalArticle

    Pharmacogenetics
    Nucleus Accumbens
    Deep Brain Stimulation
    Ethanol
    Alcoholism
    2013

    A disinhibitory circuit mediates motor integration in the somatosensory cortex

    Lee, S., Kruglikov, I., Huang, Z. J., Fishell, G. & Rudy, B., Nov 1 2013, In : Nature Neuroscience. 16, 11, p. 1662-1670 9 p.

    Research output: Contribution to journalArticle

    Somatosensory Cortex
    Interneurons
    Vasoactive Intestinal Peptide
    Pyramidal Cells
    Somatostatin

    A modular gain-of-function approach to generate cortical interneuron subtypes from ES cells

    Au, E., Ahmed, T., Karayannis, T., Biswas, S., Gan, L. & Fishell, G., Dec 4 2013, In : Neuron. 80, 5, p. 1145-1158 14 p.

    Research output: Contribution to journalArticle

    Interneurons
    Stem Cells
    Transcription Factors
    Population
    Genes

    CaV2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures

    Rossignol, E., Kruglikov, I., Van Den Maagdenberg, A. M. J. M., Rudy, B. & Fishell, G., Aug 1 2013, In : Annals of Neurology. 74, 2, p. 209-222 14 p.

    Research output: Contribution to journalArticle

    Interneurons
    Seizures
    Parvalbumins
    Generalized Epilepsy
    Pyramidal Cells

    Directed Migration of Cortical Interneurons Depends on the Cell-Autonomous Action of Sip1

    van den Berghe, V., Stappers, E., Vandesande, B., Dimidschstein, J., Kroes, R., Francis, A., Conidi, A., Lesage, F., Dries, R., Cazzola, S., Berx, G., Kessaris, N., Vanderhaeghen, P., van IJcken, W., Grosveld, F. G., Goossens, S., Haigh, J. J., Fishell, G., Goffinet, A., Aerts, S. & 2 others, Huylebroeck, D. & Seuntjens, E., Jan 9 2013, In : Neuron. 77, 1, p. 70-82 13 p.

    Research output: Contribution to journalArticle

    Interneurons
    Telencephalon
    Median Eminence
    Neocortex
    RNA Sequence Analysis

    New insights into the classification and nomenclature of cortical GABAergic interneurons

    Defelipe, J., López-Cruz, P. L., Benavides-Piccione, R., Bielza, C., Larrañaga, P., Anderson, S., Burkhalter, A., Cauli, B., Fairén, A., Feldmeyer, D., Fishell, G., Fitzpatrick, D., Freund, T. F., González-Burgos, G., Hestrin, S., Hill, S., Hof, P. R., Huang, J., Jones, E. G., Kawaguchi, Y. & 22 others, Kisvárday, Z., Kubota, Y., Lewis, D. A., Marín, O., Markram, H., McBain, C. J., Meyer, H. S., Monyer, H., Nelson, S. B., Rockland, K., Rossier, J., Rubenstein, J. L. R., Rudy, B., Scanziani, M., Shepherd, G. M., Sherwood, C. C., Staiger, J. F., Tamás, G., Thomson, A., Weng, Y., Yuste, R. & Ascoli, G. A., Mar 1 2013, In : Nature Reviews Neuroscience. 14, 3, p. 202-216 15 p.

    Research output: Contribution to journalArticle

    Interneurons
    Terminology
    Neurons
    Expert Systems
    Bayes Theorem

    Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons

    Owen, S. F., Tuncdemir, S. N., Bader, P. L., Tirko, N. N., Fishell, G. & Tsien, R. W., Aug 8 2013, In : Nature. 500, 7463, p. 458-462 5 p.

    Research output: Contribution to journalArticle

    Interneurons
    Oxytocin
    Pyramidal Cells
    Synapses
    Oxytocin Receptors
    2012

    Dynamic changes in interneuron morphophysiological properties mark the maturation of hippocampal network activity

    Allene, C., Picardo, M. A., Becq, H., Miyoshi, G., Fishell, G. & Cossart, R., May 9 2012, In : Journal of Neuroscience. 32, 19, p. 6688-6698 11 p.

    Research output: Contribution to journalArticle

    GABAergic Neurons
    Interneurons
    Synapses
    Hippocampus
    Gap Junctions

    Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors into the Cortical Plate

    Miyoshi, G. & Fishell, G., Jun 21 2012, In : Neuron. 74, 6, p. 1045-1058 14 p.

    Research output: Contribution to journalArticle

    Pyramidal Cells
    Cerebral Cortex
    Forkhead Transcription Factors
    Axons
    Down-Regulation

    Functional adaptation of cortical interneurons to attenuated activity is subtype-specific

    Karayannis, T., García, N. V. D. M. & Fishell, G., Sep 24 2012, In : Frontiers in Neural Circuits. SEPTEMBER

    Research output: Contribution to journalArticle

    Interneurons
    Pyramidal Cells
    Potassium Channels
    Homeostasis
    Neurons

    Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus

    Marissal, T., Bonifazi, P., Picardo, M. A., Nardou, R., Petit, L. F., Baude, A., Fishell, G., Ben-Ari, Y. & Cossart, R., Dec 1 2012, In : Nature Communications. 3, 2318.

    Research output: Contribution to journalArticle

    hippocampus
    neurons
    Neurons
    Hippocampus
    cells

    Satb1 is an activity-modulated transcription factor required for the terminal differentiation and connectivity of medial ganglionic eminence-derived cortical interneurons

    Close, J., Xu, H., García, N. D. M., Batista-Brito, R., Rossignol, E., Rudy, B. & Fishell, G., Dec 5 2012, In : Journal of Neuroscience. 32, 49, p. 17690-17705 16 p.

    Research output: Contribution to journalArticle

    Median Eminence
    Interneurons
    Transcription Factors
    Parvalbumins
    Somatostatin-Secreting Cells

    Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

    Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., Aja, S., Ford, E., Fishell, G. & Blackshaw, S., May 1 2012, In : Nature Neuroscience. 15, 5, p. 700-702 3 p.

    Research output: Contribution to journalArticle

    Ependymoglial Cells
    Median Eminence
    Neurogenesis
    Diet
    Neurons

    The origin of neocortical nitric oxide synthase-expressing inhibitory neurons

    Jaglin, X. H., Hjerling-Leffler, J., Fishell, G. & Batista-Brito, R., Jul 9 2012, In : Frontiers in Neural Circuits. JULY 2012

    Research output: Contribution to journalArticle

    Nitric Oxide Synthase Type I
    Nitric Oxide Synthase
    Neurons
    GABAergic Neurons
    Interneurons
    2011

    A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex

    Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., Miyoshi, G., Shima, Y., Fishell, G., Nelson, S. B. & Huang, Z. J., Sep 22 2011, In : Neuron. 71, 6, p. 995-1013 19 p.

    Research output: Contribution to journalArticle

    GABAergic Neurons
    Interneurons
    Cerebral Cortex
    Genetic Engineering
    Cognition

    Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus

    Encinas, J. M., Michurina, T. V., Peunova, N., Park, J. H., Tordo, J., Peterson, D. A., Fishell, G., Koulakov, A. & Enikolopov, G., May 6 2011, In : Cell Stem Cell. 8, 5, p. 566-579 14 p.

    Research output: Contribution to journalArticle

    Neural Stem Cells
    Hippocampus
    Neurons
    Neurogenesis
    Astrocytes

    GABAergic interneuron lineages selectively sort into specific cortical layers during early postnatal development

    Miyoshi, G. & Fishell, G., Apr 1 2011, In : Cerebral Cortex. 21, 4, p. 845-852 8 p.

    Research output: Contribution to journalArticle

    Interneurons
    Cerebral Cortex
    Population
    Median Eminence
    Up-Regulation

    Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip

    Machold, R., Klein, C. & Fishell, G., Jun 1 2011, In : Gene Expression Patterns. 11, 5-6, p. 349-359 11 p.

    Research output: Contribution to journalArticle

    Lip
    Genes
    Brain Stem
    Basic Helix-Loop-Helix Transcription Factors
    Fourth Ventricle

    Mechanisms of inhibition within the telencephalon: "Where the wild things are"

    Fishell, G. & Rudy, B., Jul 21 2011, In : Annual Review of Neuroscience. 34, p. 535-567 33 p.

    Research output: Contribution to journalArticle

    Telencephalon
    Interneurons
    Amygdala
    Terminology
    Population

    Neuronal activity is required for the development of specific cortical interneuron subtypes

    De Marco García, N. V., Karayannis, T. & Fishell, G., Apr 21 2011, In : Nature. 472, 7343, p. 351-355 5 p.

    Research output: Contribution to journalArticle

    Interneurons
    Calbindin 2
    Pyramidal Cells
    Dendrites
    Axons

    Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus

    Picardo, M. A., Guigue, P., Bonifazi, P., Batista-Brito, R., Allene, C., Ribas, A., Fishell, G., Baude, A. & Cossart, R., Aug 25 2011, In : Neuron. 71, 4, p. 695-709 15 p.

    Research output: Contribution to journalArticle

    GABAergic Neurons
    Hippocampus
    Neurons
    Interneurons

    Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons

    Rudy, B., Fishell, G., Lee, S. H. & Hjerling-Leffler, J., Jan 1 2011, In : Developmental Neurobiology. 71, 1, p. 45-61 17 p.

    Research output: Contribution to journalArticle

    GABAergic Neurons
    Interneurons
    Neurons
    Parvalbumins
    Somatostatin
    2010

    Common origins of hippocampal ivy and nitric oxide synthase expressing neurogliaform cells

    Tricoire, L., Pelkey, K. A., Daw, M. I., Sousa, V. H., Miyoshi, G., Jeffries, B., Cauli, B., Fishell, G. & McBain, C. J., Feb 10 2010, In : Journal of Neuroscience. 30, 6, p. 2165-2176 12 p.

    Research output: Contribution to journalArticle

    Nitric Oxide Synthase Type I
    Interneurons
    Nitric Oxide Synthase
    Protein Isoforms
    Median Eminence

    Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons

    Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P. & Fishell, G., Feb 3 2010, In : Journal of Neuroscience. 30, 5, p. 1582-1594 13 p.

    Research output: Contribution to journalArticle

    Interneurons
    Population
    Median Eminence
    Pyramidal Cells
    Vasoactive Intestinal Peptide

    Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala

    Carney, R. S. E., Mangin, J. M., Hayes, L., Mansfield, K., Sousa, V. H., Fishell, G., Machold, R. P., Ahn, S., Gallo, V. & Corbin, J. G., May 27 2010, In : Neural Development. 5, 1, 14.

    Research output: Contribution to journalArticle

    Hedgehogs
    Amygdala
    Neurons
    Calbindins
    Limbic System