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Gennaro Esposito

Visiting Professor of Chemistry

1982 …2018
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Research Output 1982 2018

2018

Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and Δn6 β2-microglobulin variants

Brancolini, G., Maschio, M. C., Cantarutti, C., Corazza, A., Fogolari, F., Bellotti, V., Corni, S. & Esposito, G., Mar 14 2018, In : Nanoscale. 10, 10, p. 4793-4806 14 p.

Research output: Contribution to journalArticle

Amyloid
Citric Acid
Gold
Dimers
Nanoparticles

Dynamics and Thermodynamics of Transthyretin Association from Molecular Dynamics Simulations

Dongmo Foumthuim, C. J., Corazza, A., Berni, R., Esposito, G. & Fogolari, F., Jan 1 2018, In : BioMed Research International. 2018, 7480749.

Research output: Contribution to journalArticle

Prealbumin
Molecular Dynamics Simulation
Thermodynamics
Molecular dynamics
Dimers

Free energy, enthalpy and entropy from implicit solvent end-point simulations

Fogolari, F., Corazza, A. & Esposito, G., Feb 8 2018, In : Frontiers in Molecular Biosciences. 5, FEB, 11.

Research output: Contribution to journalArticle

Entropy
Free energy
Enthalpy
Solvation
Biological systems

Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Cantarutti, C., Raj, G., Fogolari, F., Giorgetti, S., Corazza, A., Bellotti, V., Naumov, P. & Esposito, G., Jan 1 2018, In : Chemical Communications. 54, 43, p. 5422-5425 4 p.

Research output: Contribution to journalArticle

Citric Acid
Gold
Nanoparticles
Proteins
Oligomers

PDB2ENTROPY and PDB2TRENT: Conformational and Translational-Rotational Entropy from Molecular Ensembles

Fogolari, F., Maloku, O., Dongmo Foumthuim, C. J., Corazza, A. & Esposito, G., Jul 23 2018, In : Journal of Chemical Information and Modeling. 58, 7, p. 1319-1324 6 p.

Research output: Contribution to journalArticle

entropy
Entropy
Molecules
Atoms
predictive model

The interaction of β2-microglobulin with gold nanoparticles: Impact of coating, charge and size

Cantarutti, C., Bertoncin, P., Posocco, P., Hunashal, Y., Giorgetti, S., Bellotti, V., Fogolari, F. & Esposito, G., Jan 1 2018, In : Journal of Materials Chemistry B. 6, 37, p. 5964-5974 11 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Proteins
Coatings
Acids

The α4β1/EMILIN1 interaction discloses a novel and unique integrin-ligand type of engagement

Capuano, A., Fogolari, F., Bucciotti, F., Spessotto, P., Nicolosi, P. A., Mucignat, M. T., Cervi, M., Esposito, G., Colombatti, A. & Doliana, R., Mar 1 2018, In : Matrix Biology. 66, p. 50-66 17 p.

Research output: Contribution to journalArticle

Integrins
Ligands
Cell Adhesion
Adhesives
Glycoproteins
2017

A specific nanobody prevents amyloidogenesis of D76N β2- microglobulin in vitro and modifies its tissue distribution in vivo

Raimondi, S., Porcari, R., Mangione, P. P., Verona, G., Marcoux, J., Giorgetti, S., Taylor, G. W., Ellmerich, S., Ballico, M., Zanini, S., Pardon, E., Al-Shawi, R., Simons, J. P., Corazza, A., Fogolari, F., Leri, M., Stefani, M., Bucciantini, M., Gillmore, J. D., Hawkins, P. N. & 6 others, Valli, M., Stoppini, M., Robinson, C. V., Steyaert, J., Esposito, G. & Bellotti, V., Jan 1 2017, In : Scientific Reports. 7, 46711.

Research output: Contribution to journalArticle

Single-Domain Antibodies
Tissue Distribution
Doxycycline
Amyloidosis
Proteins

Automation of peak-tracking analysis of stepwise perturbed NMR spectra

Banelli, T., Vuano, M., Fogolari, F., Fusiello, A., Esposito, G. & Corazza, A., Feb 1 2017, In : Journal of Biomolecular NMR. 67, 2, p. 121-134 14 p.

Research output: Contribution to journalArticle

Chemical Evolution
Architectural Accessibility
Automation
Chemical shift
Signal-To-Noise Ratio

Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin

Cantarutti, C., Raimondi, S., Brancolini, G., Corazza, A., Giorgetti, S., Ballico, M., Zanini, S., Palmisano, G., Bertoncin, P., Marchese, L., Patrizia Mangione, P., Bellotti, V., Corni, S., Fogolari, F. & Esposito, G., Mar 21 2017, In : Nanoscale. 9, 11, p. 3941-3951 11 p.

Research output: Contribution to journalArticle

Citric Acid
Gold
Nanoparticles
Amyloidogenic Proteins
Nuclear magnetic resonance

Molecular dynamics simulations of β2-microglobulin interaction with hydrophobic surfaces

Dongmo Foumthuim, C. J., Corazza, A., Esposito, G. & Fogolari, F., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2625-2637 13 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Hydrophobic and Hydrophilic Interactions
Adsorption
Proteins
Thermodynamics

Topological transformation of a trefoil knot into a [2]catenane

Prakasam, T., Bilbeisi, R. A., El-Khoury, R., Charbonnière, L. J., Elhabiri, M., Esposito, G., Olsen, J. C. & Trabolsi, A., Jan 1 2017, In : Dalton Transactions. 46, 47, p. 16474-16479 6 p.

Research output: Contribution to journalArticle

Cadmium
Zinc
Imines
Bromides
Temperature
2016

Accurate Estimation of the Entropy of Rotation-Translation Probability Distributions

Fogolari, F., Dongmo Foumthuim, C. J., Fortuna, S., Soler, M. A., Corazza, A. & Esposito, G., Jan 12 2016, In : Journal of Chemical Theory and Computation. 12, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Probability distributions
Entropy
entropy
estimates
histograms

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

Camilloni, C., Sala, B. M., Sormanni, P., Porcari, R., Corazza, A., De Rosa, M., Zanini, S., Barbiroli, A., Esposito, G., Bolognesi, M., Bellotti, V., Vendruscolo, M. & Ricagno, S., May 6 2016, In : Scientific Reports. 6, 25559.

Research output: Contribution to journalArticle

beta 2-Microglobulin
Mutation
Amyloidosis
Molecular Dynamics Simulation
Dialysis
2015
Poisson-Boltzmann Equation
Reparametrization
Boltzmann equation
Nucleic acids
Nucleic Acids

Distance-based configurational entropy of proteins from molecular dynamics simulations

Fogolari, F., Corazza, A., Fortuna, S., Soler, M. A., Van Schouwen, B., Brancolini, G., Corni, S., Melacini, G. & Esposito, G., Jul 15 2015, In : PLoS One. 10, 7, e0132356.

Research output: Contribution to journalArticle

molecular dynamics
Entropy
Molecular Dynamics Simulation
entropy
Molecular dynamics

Probing the influence of citrate-capped gold nanoparticles on an amyloidogenic protein

Brancolini, G., Corazza, A., Vuano, M., Fogolari, F., Mimmi, M. C., Bellotti, V., Stoppini, M., Corni, S. & Esposito, G., Jan 1 2015, In : ACS Nano. 9, 3, p. 2600-2613 14 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
citrates
Citric Acid
Gold
gold
2014

Class I major histocompatibility complex, the Trojan Horse for secretion of Amyloidogenic β2-Microglobulin

Halabelian, L., Ricagno, S., Giorgetti, S., Santambrogio, C., Barbiroli, A., Pellegrino, S., Achour, A., Grandori, R., Marchese, L., Raimondi, S., Mangione, P. P., Esposito, G., Al-Shawi, R., Simons, J. P., Speck, I., Stoppini, M., Bolognesi, M. & Bellotti, V., Feb 7 2014, In : Journal of Biological Chemistry. 289, 6, p. 3318-3327 10 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Quality control
Amyloidogenic Proteins
Stabilization
Proteolysis

CNN pincer ruthenium catalysts for hydrogenation and transfer hydrogenation of ketones: Experimental and computational studies

Baratta, W., Baldino, S., Calhorda, M. J., Costa, P. J., Esposito, G., Herdtweck, E., Magnolia, S., Mealli, C., Messaoudi, A., Mason, S. A. & Veiros, L. F., Oct 1 2014, In : Chemistry - A European Journal. 20, 42, p. 13603-13617 15 p.

Research output: Contribution to journalArticle

Ruthenium
Ketones
Hydrogenation
Alcohols
Hydrides
2013

Absolute quantification of choline-related biomarkers in breast cancer biopsies by liquid chromatography electrospray ionization mass spectrometry

Mimmi, M. C., Finato, N., Pizzolato, G., Beltrami, C. A., Fogolari, F., Corazza, A. & Esposito, G., Nov 25 2013, In : Analytical Cellular Pathology. 36, 3-4, p. 71-83 13 p.

Research output: Contribution to journalArticle

Electrospray Ionization Mass Spectrometry
Choline
Liquid Chromatography
Phosphorylcholine
Biomarkers

A differential equation for the Generalized Born radii

Fogolari, F., Corazza, A. & Esposito, G., Jun 28 2013, In : Physical Chemistry Chemical Physics. 15, 24, p. 9783-9791 9 p.

Research output: Contribution to journalArticle

Differential equations
differential equations
Born approximation
radii
Laplace equation

Carnosine Inhibits Aβ42 Aggregation by Perturbing the H-Bond Network in and around the Central Hydrophobic Cluster

Attanasio, F., Convertino, M., Magno, A., Caflisch, A., Corazza, A., Haridas, H., Esposito, G., Cataldo, S., Pignataro, B., Milardi, D. & Rizzarelli, E., Mar 1 2013, In : ChemBioChem. 14, 5, p. 583-592 10 p.

Research output: Contribution to journalArticle

Carnosine
Agglomeration
Molecular Dynamics Simulation
Molecular dynamics
Hydrogen

Generalized Born forces: Surface integral formulation

Fogolari, F., Corazza, A. & Esposito, G., Feb 7 2013, In : Journal of Chemical Physics. 138, 5, 054112.

Research output: Contribution to journalArticle

formulations
radii
Solvation
solvation
discontinuity

Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers

Esposito, G., Garvey, M., Alverdi, V., Pettirossi, F., Corazza, A., Fogolari, F., Polano, M., Mangione, P. P., Giorgetti, S., Stoppini, M., Rekas, A., Bellotti, V., Heck, A. J. R. & Carver, J. A., Jun 14 2013, In : Journal of Biological Chemistry. 288, 24, p. 17844-17858 15 p.

Research output: Contribution to journalArticle

Crystallins
Molecular Chaperones
Oligomers
Mass spectrometry
Mass Spectrometry

Oligomeric states along the folding pathways of β2-microglobulin: Kinetics, thermodynamics, and structure

Rennella, E., Cutuil, T., Schanda, P., Ayala, I., Gabel, F., Forge, V., Corazza, A., Esposito, G. & Brutscher, B., Aug 9 2013, In : Journal of Molecular Biology. 425, 15, p. 2722-2736 15 p.

Research output: Contribution to journalArticle

Thermodynamics
Amyloid
Proteins
Amyloidogenic Proteins
Protein Conformation

Protein aggregation measurement through electrical impedance spectroscopy

Affanni, A., Corazza, A., Esposito, G., Fogolari, F. & Polano, M., Jan 1 2013, In : Journal of Physics: Conference Series. 459, 1, 012049.

Research output: Contribution to journalConference article

electrical impedance
impedance
methodology
proteins
calculators

Reduction of conformational mobility and aggregation in W60G β2-microglobulin: Assessment by 15N NMR relaxation

Gümral, D., Fogolari, F., Corazza, A., Viglino, P., Giorgetti, S., Stoppini, M., Bellotti, V. & Esposito, G., Dec 1 2013, In : Magnetic Resonance in Chemistry. 51, 12, p. 795-807 13 p.

Research output: Contribution to journalArticle

Mutant Proteins
Amyloid
Tryptophan
Molecular dynamics
Agglomeration

Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin roles of shear flow, hydrophobic surfaces, and α-crystallin

Mangione, P. P., Esposito, G., Relini, A., Raimondi, S., Porcari, R., Giorgetti, S., Corazza, A., Fogolari, F., Penco, A., Goto, Y., Lee, Y. H., Yagi, H., Cecconi, C., Naqvi, M. M., Gillmore, J. D., Hawkins, P. N., Chiti, F., Rolandi, R., Taylor, G. W., Pepys, M. B. & 2 others, Stoppini, M. & Bellotti, V., Oct 25 2013, In : Journal of Biological Chemistry. 288, 43, p. 30917-30930 14 p.

Research output: Contribution to journalArticle

Crystallins
Shear flow
Amyloid
Amyloidosis
Familial Amyloidosis
2012

Bluues: A program for the analysis of the electrostatic properties of proteins based on generalized Born radii

Fogolari, F., Corazza, A., Yarra, V., Jalaru, A., Viglino, P. & Esposito, G., Mar 28 2012, In : BMC Bioinformatics. 13, SUPPL.4, S18.

Research output: Contribution to journalArticle

Static Electricity
Electrostatics
Radius
Proteins
Protein

Bluues server: Electrostatic properties of wild-type and mutated protein structures

Walsh, I., Minervini, G., Corazza, A., Esposito, G., Tosatto, S. C. E. & Fogolari, F., Aug 1 2012, In : Bioinformatics. 28, 16, p. 2189-2190 2 p., bts343.

Research output: Contribution to journalArticle

Protein Structure
Static Electricity
Electrostatics
Servers
Server

Determining the energy landscape of proteins by a fast isotope exchange NMR approach

Rennella, E., Corazza, A., Codutti, L., Bellotti, V., Stoppini, M., Viglino, P., Fogolari, F. & Esposito, G., Mar 14 2012, In : Journal of the American Chemical Society. 134, 10, p. 4457-4460 4 p.

Research output: Contribution to journalArticle

Isotopes
Nuclear magnetic resonance
Proteins
Architectural Accessibility
Thermodynamics

Fast structure similarity searches among protein models: Efficient clustering of protein fragments

Fogolari, F., Corazza, A., Viglino, P. & Esposito, G., May 29 2012, In : Algorithms for Molecular Biology. 7, 1, 16.

Research output: Contribution to journalArticle

Similarity Search
Root mean square deviation
Cluster Analysis
Fragment
Clustering

Is Water Diffusion Isotropic in the Cirrhotic Liver? A Study with Diffusion-weighted Imaging at 3.0 Tesla

Girometti, R., Esposito, G., Bagatto, D., Avellini, C., Bazzocchi, M. & Zuiani, C., Jan 1 2012, In : Academic Radiology. 19, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

Water
Liver
Perfusion
Liver Cirrhosis
Direction compound

Pathological self-aggregation of β(2)-microglobulin: a challenge for protein biophysics.

Esposito, G., Corazza, A. & Bellotti, V., Dec 1 2012, In : Sub-Cellular Biochemistry. 65, p. 165-183 19 p.

Research output: Contribution to journalReview article

Biophysics
Agglomeration
Atomic Force Microscopy
Prions
Electron microscopy

Rapid oligomer formation of human muscle acylphosphatase induced by heparan sulfate

Motamedi-Shad, N., Garfagnini, T., Penco, A., Relini, A., Fogolari, F., Corazza, A., Esposito, G., Bemporad, F. & Chiti, F., May 1 2012, In : Nature Structural and Molecular Biology. 19, 5, p. 547-554 8 p.

Research output: Contribution to journalArticle

Heparitin Sulfate
Muscles
Amyloid Plaques
Basic Amino Acids
Proteins

Single-shot NMR measurement of protein unfolding landscapes

Rennella, E., Corazza, A., Codutti, L., Causero, A., Bellotti, V., Stoppini, M., Viglino, P., Fogolari, F. & Esposito, G., Jun 1 2012, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1824, 6, p. 842-849 8 p.

Research output: Contribution to journalArticle

Protein Unfolding
Thermodynamics
Nuclear magnetic resonance
Amyloidogenic Proteins
Biophysics

Studying interactions by molecular dynamics simulations at high concentration

Fogolari, F., Corazza, A., Toppo, S., Tosatto, S. C. E., Viglino, P., Ursini, F. & Esposito, G., Mar 16 2012, In : Journal of Biomedicine and Biotechnology. 2012, 303190.

Research output: Contribution to journalArticle

beta 2-Microglobulin
Molecular Dynamics Simulation
Glutathione Peroxidase
Hydrogen Peroxide
Molecular dynamics

The EMILIN/multimerin family

Colombatti, A., Spessotto, P., Doliana, R., Mongiat, M., Bressan, G. M. & Esposito, G., Dec 1 2012, In : Frontiers in Immunology. 2, JAN, Article 93.

Research output: Contribution to journalReview article

Elastin
Integrins
Bacillus anthracis
Hemostasis
Extracellular Matrix
2011

Effect of tetracyclines on the dynamics of formation and destructuration of β2-microglobulin amyloid fibrils

Giorgetti, S., Raimondi, S., Pagano, K., Relini, A., Bucciantini, M., Corazza, A., Fogolari, F., Codutti, L., Salmona, M., Mangione, P., Colombo, L., De Luigi, A., Porcari, R., Gliozzi, A., Stefani, M., Esposito, G., Bellotti, V. & Stoppini, M., Jan 21 2011, In : Journal of Biological Chemistry. 286, 3, p. 2121-2131 11 p.

Research output: Contribution to journalArticle

Tetracyclines
Doxycycline
Amyloid
Amyloidosis
Pharmaceutical Preparations

High-performance metabolic marker assessment in breast cancer tissue by mass spectrometry

Mimmi, M. C., Picotti, P., Corazza, A., Betto, E., Pucillo, C. E., Cesaratto, L., Cedolini, C., Londero, V., Zuiani, C., Bazzocchi, M. & Esposito, G., Feb 1 2011, In : Clinical Chemistry and Laboratory Medicine. 49, 2, p. 317-324 8 p.

Research output: Contribution to journalArticle

Choline
Phosphorylcholine
Mass spectrometry
Mass Spectrometry
Electrospray ionization

Molecular dynamics simulation of β 2-microglobulin in denaturing and stabilizing conditions

Fogolari, F., Corazza, A., Varini, N., Rotter, M., Gumral, D., Codutti, L., Rennella, E., Viglino, P., Bellotti, V. & Esposito, G., Mar 1 2011, In : Proteins: Structure, Function and Bioinformatics. 79, 3, p. 986-1001 16 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Molecular dynamics
Computer simulation
Isomerization
Amyloid

Study of the reaction between carbamoyl azides of α-N-protected amino acids and hydrazine monohydrate

Verardo, G., Venneri, C. D., Esposito, G. & Strazzolini, P., Mar 1 2011, In : European Journal of Organic Chemistry. 7, p. 1376-1384 9 p.

Research output: Contribution to journalArticle

hydrazine
Semicarbazides
Azides
hydrazines
amino acids

The two tryptophans of 2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure

Raimondi, S., Barbarini, N., Mangione, P., Esposito, G., Ricagno, S., Bolognesi, M., Zorzoli, I., Marchese, L., Soria, C., Bellazzi, R., Monti, M., Stoppini, M., Stefanelli, M., Magni, P. & Bellotti, V., Jan 1 2011, In : BMC Evolutionary Biology. 11, 1, 159.

Research output: Contribution to journalArticle

tryptophan
folding
major histocompatibility complex
protein
cavity
2010

Emerging Molecular Targets in the Therapy of Dialysis-Related Amyloidosis

Esposito, G. & Bellotti, V., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 843-865 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloidosis
Dialysis
Therapeutics

Folding and fibrillogenesis: Clues from β2-microglobulin

Rennella, E., Corazza, A., Giorgetti, S., Fogolari, F., Viglino, P., Porcari, R., Verga, L., Stoppini, M., Bellotti, V. & Esposito, G., Aug 1 2010, In : Journal of Molecular Biology. 401, 2, p. 286-297 12 p.

Research output: Contribution to journalArticle

Trifluoroethanol
Amyloid
Alcohols
Mutant Proteins
Renal Insufficiency

Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein β2-microglobulin revealed by real-time two-dimensional NMR

Corazza, A., Rennella, E., Schanda, P., Mimmi, M. C., Cutuil, T., Raimondi, S., Giorgetti, S., Fogolari, F., Viglino, P., Frydman, L., Gal, M., Bellotti, V., Brutscher, B. & Esposito, G., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5827-5835 9 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Dialysis
Amyloid
Nuclear magnetic resonance
Kinetics

Structural and dynamics characteristics of acylphosphatase from Sulfolobus solfataricus in the monomeric state and in the initial native-like aggregates

Pagano, K., Bemporad, F., Fogolari, F., Esposito, G., Viglino, P., Chiti, F. & Corazza, A., May 7 2010, In : Journal of Biological Chemistry. 285, 19, p. 14689-14700 12 p.

Research output: Contribution to journalArticle

Sulfolobus solfataricus
Deuterium
Hydrogen
Proteins
Ferredoxins
2009

Clinical, radiological, and biochemical features of a bilateral buttock amyloidoma emerging after 27 years of hemodialysis

Montagna, G., Raimondi, S., Moro, G., Uggetti, C., Relini, A., Magrini, U., Esposito, G., Giorgetti, S., Congi, L., Mosconi, M., Galli, G., Villa, G., Segagni, S., Donadei, S., Obici, L., Merlini, G., Stoppini, M. & Bellotti, V., Dec 4 2009, In : Amyloid. 16, 3, p. 115-121 7 p.

Research output: Contribution to journalArticle

Buttocks
Amyloid
Renal Dialysis
Subcutaneous Fat
Amyloidosis

Conformational stability of neuroglobin helix F - Possible effects on the folding pathway within the globin family

Codutti, L., Picotti, P., Marin, O., Dewilde, S., Fogolari, F., Corazza, A., Viglino, P., Moens, L., Esposito, G. & Fontana, A., Sep 1 2009, In : FEBS Journal. 276, 18, p. 5177-5190 14 p.

Research output: Contribution to journalArticle

Globins
Myoglobin
Heme
Conformations
Proteins

Equilibrium unfolding thermodynamics of β2-microglobulin analyzed through native-state H/D exchange

Rennella, E., Corazza, A., Fogolari, F., Viglino, P., Giorgetti, S., Stoppini, M., Bellotti, V. & Esposito, G., Jan 7 2009, In : Biophysical Journal. 96, 1, p. 169-179 11 p.

Research output: Contribution to journalArticle

Thermodynamics
Amyloidogenic Proteins
Amyloidosis
Hydrogen Bonding
Amides