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David Fitch

Professor Of Biology

1980 …2019
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Research Output 1980 2019

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Article
2019

The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28

Kiontke, K. C., Herrera, R. A., Vuong, E., Luo, J., Schwarz, E. M., Fitch, D. & Portman, D. S., May 20 2019, In : Developmental Cell. 49, 4, p. 542-555.e9

Research output: Contribution to journalArticle

Long Noncoding RNA
MicroRNAs
Morphogenesis
Tail
Caenorhabditis

The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system

Lawson, H., Vuong, E., Miller, R. M., Kiontke, K., Fitch, D. & Portman, D. S., Jul 2 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Sexual Maturation
Neurology
Nervous System
Sex Differentiation
2018

From “the worm” to “the worms” and back again: The evolutionary developmental biology of nematodes

Haag, E. S., Fitch, D. & Delattre, M., Oct 1 2018, In : Genetics. 210, 2, p. 397-433 37 p.

Research output: Contribution to journalArticle

Developmental Biology
Caenorhabditis elegans
Caenorhabditis
Phylogeny
Cell Biology
2017

Genome Architecture and Evolution of a Unichromosomal Asexual Nematode

Fradin, H., Kiontke, K., Zegar, C., Gutwein, M., Lucas, J., Kovtun, M., Corcoran, D. L., Baugh, L. R., Fitch, D. H. A., Piano, F. & Gunsalus, K. C., 2017, (Accepted/In press) In : Current Biology.

Research output: Contribution to journalArticle

Chromosomes
heterozygosity
Genes
Nematoda
Genome
2016

Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans

Antonio Herrera, R., Kiontke, K. & Fitch, D., Mar 1 2016, In : Development. 143, 5, p. 799-809 11 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Genes
Molting
Sexual Behavior
Proteolysis
2014

A critique of Rossberg et al. Noise obscures the genetic signal of meiobiotal ecospecies in ecogenomic datasets

Morgan, M. J., Bass, D., Bik, H., Birky, C. W., Blaxter, M., Crisp, M. D., Derycke, S., Fitch, D., Fontaneto, D., Hardy, C. M., King, A. J., Kiontke, K. C., Moens, T., Pawlowski, J. W., Porazinska, D., Tang, C. Q., Thomas, W. K., Yeates, D. K. & Creer, S., May 22 2014, In : Proceedings. Biological sciences / The Royal Society. 281, 1783, p. 20133076 1 p.

Research output: Contribution to journalArticle

Error analysis
Signal to noise ratio
Genomics

Comparative validation of the D. melanogaster modENCODE transcriptome annotation

Chen, Z. X., Sturgill, D., Qu, J., Jiang, H., Park, S., Boley, N., Suzuki, A. M., Fletcher, A. R., Plachetzki, D. C., FitzGerald, P. C., Artieri, C. G., Atallah, J., Barmina, O., Brown, J. B., Blankenburg, K. P., Clough, E., Dasgupta, A., Gubbala, S., Han, Y., Jayaseelan, J. C. & 43 others, Kalra, D., Kim, Y. A., Kovar, C. L., Lee, S. L., Li, M., Malley, J. D., Malone, J. H., Mathew, T., Mattiuzzo, N. R., Munidasa, M., Muzny, D. M., Ongeri, F., Perales, L., Przytycka, T. M., Pu, L. L., Robinson, G., Thornton, R. L., Saada, N., Scherer, S. E., Smith, H. E., Vinson, C., Warner, C. B., Worley, K. C., Wu, Y. Q., Zou, X., Cherbas, P., Kellis, M., Eisen, M. B., Piano, F., Kionte, K., Fitch, D. H., Sternberg, P. W., Cutter, A. D., Duff, M. O., Hoskins, R. A., Graveley, B. R., Gibbs, R. A., Bickel, P. J., Kopp, A., Carninci, P., Celniker, S. E., Oliver, B. & Richards, S., 2014, In : Genome Research. 24, 7, p. 1209-1223 15 p.

Research output: Contribution to journalArticle

Transcriptome
Genome
Drosophila
Molecular Sequence Annotation
Genetic Testing
2013

Nematodes

Kiontke, K. & Fitch, D. H. A., Oct 7 2013, In : Current Biology. 23, 19

Research output: Contribution to journalArticle

Caenorhabditis elegans
Cell death
Green Fluorescent Proteins
Gene expression
Genes
2011

A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans

Nelson, M. D., Zhou, E., Kiontke, K., Fradin, H., Maldonado, G., Martin, D., Shah, K. & Fitch, D. H. A., Mar 2011, In : PLoS Genetics. 7, 3, e1002010.

Research output: Contribution to journalArticle

morphogenesis
Caenorhabditis elegans
RNA Interference
Morphogenesis
genome

A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits

Kiontke, K. C., Félix, M. A., Ailion, M., Rockman, M. V., Braendle, C., Pénigault, J. B. & Fitch, D. H. A., 2011, In : BMC Evolutionary Biology. 11, 1, 339.

Research output: Contribution to journalArticle

Caenorhabditis
barcoding
Caenorhabditis elegans
phylogeny
fruit

Overlap extension PCR: an efficient method for transgene construction.

Nelson, M. D. & Fitch, D. H. A., 2011, In : Methods in Molecular Biology. 772, p. 459-470 12 p.

Research output: Contribution to journalArticle

Transgenes
Polymerase Chain Reaction
Genes
Mutation
Biological Science Disciplines
2010

David fitch

Fitch, D., Oct 26 2010, In : Current Biology. 20, 20

Research output: Contribution to journalArticle

Phenotypic plasticity: Different teeth for different feasts

Kiontke, K. & Fitch, D. H. A., Sep 14 2010, In : Current Biology. 20, 17

Research output: Contribution to journalArticle

Genetic Models
phenotypic plasticity
Cues
Plasticity
Tooth
2009

Evolution of early embryogenesis in rhabditid nematodes

Brauchle, M., Kiontke, K., MacMenamin, P., Fitch, D. H. A. & Piano, F., Nov 1 2009, In : Developmental Biology. 335, 1, p. 253-262 10 p.

Research output: Contribution to journalArticle

Embryonic Development
Embryonic Structures
Phenotype
Cell Polarity
Phylogeny
2008

Dropout alignment allows homology recognition and evolutionary analysis of rDNA intergenic spacers

Ryu, S., Do, Y., Fitch, D. H. A., Kim, W. & Mishra, B., Apr 2008, In : Journal of Molecular Evolution. 66, 4, p. 368-383 16 p.

Research output: Contribution to journalArticle

dropouts
Ribosomal DNA
intergenic DNA
homology
RNA Polymerase I

Teratorhabditis synpapillata Sudhaus, 1985 (Rhabditida: Rhabditidae) is an associate of the red palm weevil, Rhynchophorus ferrugineus (Coleoptera: Curculionidae)

Kanzaki, N., Abe, F., Giblin-Davis, R. M., Kiontke, K., Fitch, D. H. A., Hata, K. & Soné, K., Jan 3 2008, In : Nematology. 10, 2, p. 207-218 12 p.

Research output: Contribution to journalArticle

Rhabditidae
Rhynchophorus ferrugineus
Curculionidae
nematode
Phoenix canariensis
2007

Caenorhabditis evolution: if they all look alike, you aren't looking hard enough

Haag, E. S., Chamberlin, H., Coghlan, A., Fitch, D. H. A., Peters, A. D. & Schulenburg, H., Mar 2007, In : Trends in Genetics. 23, 3, p. 101-104 4 p.

Research output: Contribution to journalArticle

Caenorhabditis
Developmental Biology
Portugal
Caenorhabditis elegans
Population Genetics

Population structure of plasmid-containing strains of Streptococcus mutans, a member of the human indigenous biota

Caufield, P. W., Saxena, D., Fitch, D. & Li, Y., Feb 2007, In : Journal of Bacteriology. 189, 4, p. 1238-1243 6 p.

Research output: Contribution to journalArticle

Biota
Streptococcus mutans
Plasmids
Phylogeny
Population

Trends, Stasis, and Drift in the Evolution of Nematode Vulva Development

Kiontke, K., Barrière, A., Kolotuev, I., Podbilewicz, B., Sommer, R., Fitch, D. H. A. & Félix, M. A., Nov 20 2007, In : Current Biology. 17, 22, p. 1925-1937 13 p.

Research output: Contribution to journalArticle

Vulva
vulva
Random processes
Stochastic Processes
Nematoda
2006

Novel gain-of-function alleles demonstrate a role for the heterochronic gene lin-41 in C. elegans male tail tip morphogenesis

Del Rio-Albrechtsen, T., Kiontke, K., Chiou, S. Y. & Fitch, D. H. A., Sep 1 2006, In : Developmental Biology. 297, 1, p. 74-86 13 p.

Research output: Contribution to journalArticle

Morphogenesis
Alleles
Genes
Phenotype
Mutation
2005

Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans

Maciejowski, J., Ahn, J. H., Cipriani, P. G., Killian, D. J., Chaudhary, A. L., Ji, I. L., Voutev, R., Johnsen, R. C., Baillie, D. L., Gunsalus, K. C., Fitch, D. H. A. & Hubbard, E. J. A., Apr 2005, In : Genetics. 169, 4, p. 1997-2011 15 p.

Research output: Contribution to journalArticle

X-Linked Genes
Caenorhabditis elegans
Germ Cells
Genes
Carisoprodol

Evolution: An ecological context for C. elegans

Fitch, D. H. A., Sep 6 2005, In : Current Biology. 15, 17

Research output: Contribution to journalArticle

nematode larvae
Caenorhabditis elegans
outcrossing
selfing
Population

Introduction to nematode evolution and ecology.

Fitch, D., 2005, In : WormBook : the online review of C. elegans biology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Biological Models
Nematoda
Ecology

The phylogenetic relationships of Caenorhabditis and other rhabditids.

Kiontke, K. & Fitch, D., 2005, In : WormBook : the online review of C. elegans biology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Caenorhabditis
Tail
Disorders of Sex Development
Phylogeny
Vertebrates
2004

Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss

Kiontke, K., Gavin, N. P., Raynes, Y., Roehrig, C., Piano, F. & Fitcht, D. H. A., Jun 15 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 24, p. 9003-9008 6 p.

Research output: Contribution to journalArticle

Caenorhabditis
Disorders of Sex Development
Phylogeny
Introns
Caenorhabditis elegans
2003

Absence of Wolbachia in Nonfilariid Nematodes

Bordenstein, S. R., Fitch, D. H. A. & Werren, J. H., Sep 2003, In : Journal of Nematology. 35, 3, p. 266-270 5 p.

Research output: Contribution to journalArticle

Wolbachia
Nematoda
polymerase chain reaction
arthropods
Arthropoda

The genome sequence of Caenorhabditis briggsae: A platform for comparative genomics

Stein, L. D., Bao, Z., Blasiar, D., Blumenthal, T., Brent, M. R., Chen, N., Chinwalla, A., Clarke, L., Clee, C., Coghlan, A., Coulson, A., D'Eustachio, P., Fitch, D. H. A., Fulton, L. A., Fulton, R. E., Griffiths-Jones, S., Harris, T. W., Hillier, L. W., Kamath, R., Kuwabara, P. E. & 16 others, Mardis, E. R., Marra, M. A., Miner, T. L., Minx, P., Mullikin, J. C., Plumb, R. W., Rogers, J., Schein, J. E., Sohrmann, M., Spieth, J., Stajich, J. E., Wei, C., Willey, D., Wilson, R. K., Durbin, R. & Waterston, R. H., 2003, In : PLoS Biology. 1, 2

Research output: Contribution to journalArticle

Caenorhabditis
Caenorhabditis briggsae
Caenorhabditis elegans
Genomics
Genes
2002

One small step for worms, one giant leap for "Bauplan?"

Fitch, D. H. A. & Sudhaus, W., 2002, In : Evolution and Development. 4, 4, p. 243-246 4 p.

Research output: Contribution to journalArticle

Nonvertebrate Chordata
developmental biology
Developmental Biology
Nematoda
Arthropods

TLP-1 is an asymmetric cell fate determinant that responds to Wnt signals and controls male tail tip morphogenesis in C. elegans

Zhao, X., Yang, Y., Fitch, D. & Herman, M. A., 2002, In : Development. 129, 6, p. 1497-1508 12 p.

Research output: Contribution to journalArticle

Morphogenesis
Cell Polarity
T-Lymphocytes
Cell Fusion
Sp Transcription Factors
2001

Comparative studies on the phylogeny and systematics of the Rhabditidae (Nematoda)

Sudhaus, W. & Fitch, D., Mar 2001, In : Journal of Nematology. 33, 1, p. 1-70 70 p.

Research output: Contribution to journalArticle

Rhabditidae
Nematoda
phylogeny
2000

Evolution of "Rhabditidae" and the male tail

Fitch, D., Sep 2000, In : Journal of Nematology. 32, 3, p. 235-244 10 p.

Research output: Contribution to journalArticle

Rhabditidae
tail
phylogeny
Caenorhabditis elegans
morphogenesis

Rearrangement of immunoglobulin genes in shark germ cells

Lee, S. S., Fitch, D., Flajnik, M. F. & Hsu, E., May 15 2000, In : Journal of Experimental Medicine. 191, 10, p. 1637-1647 11 p.

Research output: Contribution to journalArticle

Sharks
Immunoglobulin Genes
Germ Cells
Genetic Recombination
Genes
1999

Morphogenesis of the Caenorhabditis elegans male tail tip

Nguyen, C. Q., Hall, D. H., Yang, Y. & Fitch, D. H. A., Mar 1 1999, In : Developmental Biology. 207, 1, p. 86-106 21 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Morphogenesis
Tail
Adherens Junctions
Electron Microscopy
1997

Evolution of male tail development in rhabditid nematodes related to Caenorhabditis elegans

Fitch, D. H. A., Mar 1997, In : Systematic Biology. 46, 1, p. 145-179 35 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
nematode
Tail
tail
Ribosomal DNA
1995

18S ribosomal RNA gene phylogeny for some rhabditidae related to Caenorhabditis

Fitch, D. H. A., Bugaj-Gaweda, B. & Emmons, S. W., 1995, In : Molecular Biology and Evolution. 12, 2, p. 346-358 13 p.

Research output: Contribution to journalArticle

Caenorhabditis
18S Ribosomal RNA
Rhabditidae
Phylogeny
Ribosomal DNA
Caenorhabditis elegans
Tail
Male Genitalia
Adherens Junctions
Indirect Fluorescent Antibody Technique
1994

Caenorhabditis vulgaris sp.n. (Nematoda: Rhabditidae): A necromenic associate of pill bugs and snails

Baird, S. E., Fitch, D. & Emmons, S. W., 1994, In : Nematologica. 40, 1-4, p. 1-11 11 p.

Research output: Contribution to journalArticle

Caenorhabditis
Rhabditidae
Nematoda
Snails
snail

Widespread occurrence of the Tc1 transposon family: Tc1-like transposons from teleost fish

Radice, A. D., Bugaj, B., Fitch, D. & Emmons, S. W., Nov 1994, In : MGG Molecular & General Genetics. 244, 6, p. 606-612 7 p.

Research output: Contribution to journalArticle

Salmo salar
Oncorhynchus mykiss
Zebrafish
Fishes
Chordata
1993

Low codon bias and high rates of synonymous substitution in Drosophila hydei and D. melanogaster histone genes

Fitch, D. & Strausbaugh, L. D., Mar 1993, In : Molecular Biology and Evolution. 10, 2, p. 397-413 17 p.

Research output: Contribution to journalArticle

Drosophila hydei
histones
codons
Codon
Histones
1992
Atelinae
Globins
5' Flanking Region
Haplorhini
Gene Conversion
1991

Duplication of the γ-globin gene mediated by L1 long interspersed repetitive elements in an early ancestor of simian primates

Fitch, D., Bailey, W. J., Tagle, D. A., Goodman, M., Sieu, L. & Slightom, J. L., 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 16, p. 7396-7400 5 p.

Research output: Contribution to journalArticle

Interspersed Repetitive Sequences
Gene Duplication
Globins
Primates
Genes

Molecular evolution of the ψη-globin gene locus: Gibbon phylogeny and the hominoid slowdown

Bailey, W. J., Fitch, D., Tagle, D. A., Czelusniak, J., Slightom, J. L. & Goodman, M., Mar 1991, In : Molecular Biology and Evolution. 8, 2, p. 155-184 30 p.

Research output: Contribution to journalArticle

Hylobates
Hylobatidae
Globins
Molecular Evolution
Hominidae

Pattern formation in the nematode epidermis: Determination of the arrangement of peripheral sense organs in the C. elegans male tail

Baird, S. E., Fitch, D., Kassem, I. A. A. & Emmons, S. W., Oct 1991, In : Development. 113, 2, p. 515-526 12 p.

Research output: Contribution to journalArticle

Sense Organs
Epidermis
Tail
Sensilla
Neurons
Gene Conversion
Phylogenetics
Scanning
Genes
Gene
1990

Molecular history of gene conversions in the primate fetal γ-globin genes: Nucleotide sequences from the common gibbon, Hylobates lar

Fitch, D., Mainone, C., Goodman, M. & Slightom, J. L., Jan 15 1990, In : Journal of Biological Chemistry. 265, 2, p. 781-793 13 p.

Research output: Contribution to journalArticle

Hylobates
Gene Conversion
Globins
Primates
Nucleotides

On the origins of tandemly repeated genes: Does histone gene copy number in Drosophila reflect chromosomal location?

Fitch, D., Strausbaugh, L. D. & Barrett, V., Apr 1990, In : Chromosoma. 99, 2, p. 118-124 7 p.

Research output: Contribution to journalArticle

Gene Dosage
Histones
Drosophila
Genes
Polytene Chromosomes

Primate evolution at the DNA level and a classification of hominoids

Goodman, M., Tagle, D. A., Fitch, D., Bailey, W., Czelusniak, J., Koop, B. F., Benson, P. & Slightom, J. L., Mar 1990, In : Journal of Molecular Evolution. 30, 3, p. 260-266 7 p.

Research output: Contribution to journalArticle

Hominidae
primate
Primates
taxonomy
DNA
1989

Molecular phylogeny of the family of apes and humans

Goodman, M., Koop, B. F., Czelusniak, J., Fitch, D., Tagle, D. A. & Slightom, J. L., 1989, In : Genome. 31, 1, p. 316-335 20 p.

Research output: Contribution to journalArticle

Hominidae
Pongidae
Phylogeny
phylogeny
1988

The spider monkey ψη-globin gene and surrounding sequences: Recent or ancient insertions of LINEs and SINEs?

Fitch, D., Mainone, C., Sligtom, J. L. & Goodman, M., 1988, In : Genomics. 3, 3, p. 237-255 19 p.

Research output: Contribution to journalArticle

Atelinae
Short Interspersed Nucleotide Elements
Globins
Hominidae
Primates
1980

External review in quality assurance

Darnell, R. E. & Fitch, D. H., 1980, In : Physical Therapy. 60, 5, p. 559-63

Research output: Contribution to journalArticle