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David Fitch

Professor Of Biology

    1980 …2019
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    Research Output 1980 2019

    2019

    The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28

    Kiontke, K. C., Herrera, R. A., Vuong, E., Luo, J., Schwarz, E. M., Fitch, D. & Portman, D. S., May 20 2019, In : Developmental Cell. 49, 4, p. 542-555.e9

    Research output: Contribution to journalArticle

    Long Noncoding RNA
    MicroRNAs
    Morphogenesis
    Tail
    Caenorhabditis

    The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system

    Lawson, H., Vuong, E., Miller, R. M., Kiontke, K., Fitch, D. & Portman, D. S., Jul 2 2019, In : eLife. 8

    Research output: Contribution to journalArticle

    Open Access
    Long Noncoding RNA
    Sexual Maturation
    Neurology
    Nervous System
    Sex Differentiation
    2018

    From “the worm” to “the worms” and back again: The evolutionary developmental biology of nematodes

    Haag, E. S., Fitch, D. & Delattre, M., Oct 1 2018, In : Genetics. 210, 2, p. 397-433 37 p.

    Research output: Contribution to journalArticle

    Developmental Biology
    Caenorhabditis elegans
    Caenorhabditis
    Phylogeny
    Cell Biology
    2017

    Genome Architecture and Evolution of a Unichromosomal Asexual Nematode

    Fradin, H., Kiontke, K., Zegar, C., Gutwein, M., Lucas, J., Kovtun, M., Corcoran, D. L., Baugh, L. R., Fitch, D. H. A., Piano, F. & Gunsalus, K. C., 2017, (Accepted/In press) In : Current Biology.

    Research output: Contribution to journalArticle

    Chromosomes
    heterozygosity
    Genes
    Nematoda
    Genome
    2016

    Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans

    Antonio Herrera, R., Kiontke, K. & Fitch, D., Mar 1 2016, In : Development. 143, 5, p. 799-809 11 p.

    Research output: Contribution to journalArticle

    Caenorhabditis elegans
    Genes
    Molting
    Sexual Behavior
    Proteolysis
    2014

    A critique of Rossberg et al. Noise obscures the genetic signal of meiobiotal ecospecies in ecogenomic datasets

    Morgan, M. J., Bass, D., Bik, H., Birky, C. W., Blaxter, M., Crisp, M. D., Derycke, S., Fitch, D., Fontaneto, D., Hardy, C. M., King, A. J., Kiontke, K. C., Moens, T., Pawlowski, J. W., Porazinska, D., Tang, C. Q., Thomas, W. K., Yeates, D. K. & Creer, S., May 22 2014, In : Proceedings. Biological sciences / The Royal Society. 281, 1783, p. 20133076 1 p.

    Research output: Contribution to journalArticle

    meiofauna
    error analysis
    genetic analysis
    Signal-To-Noise Ratio
    Genomics

    Comparative validation of the D. melanogaster modENCODE transcriptome annotation

    Chen, Z. X., Sturgill, D., Qu, J., Jiang, H., Park, S., Boley, N., Suzuki, A. M., Fletcher, A. R., Plachetzki, D. C., FitzGerald, P. C., Artieri, C. G., Atallah, J., Barmina, O., Brown, J. B., Blankenburg, K. P., Clough, E., Dasgupta, A., Gubbala, S., Han, Y., Jayaseelan, J. C. & 43 others, Kalra, D., Kim, Y. A., Kovar, C. L., Lee, S. L., Li, M., Malley, J. D., Malone, J. H., Mathew, T., Mattiuzzo, N. R., Munidasa, M., Muzny, D. M., Ongeri, F., Perales, L., Przytycka, T. M., Pu, L. L., Robinson, G., Thornton, R. L., Saada, N., Scherer, S. E., Smith, H. E., Vinson, C., Warner, C. B., Worley, K. C., Wu, Y. Q., Zou, X., Cherbas, P., Kellis, M., Eisen, M. B., Piano, F., Kionte, K., Fitch, D. H., Sternberg, P. W., Cutter, A. D., Duff, M. O., Hoskins, R. A., Graveley, B. R., Gibbs, R. A., Bickel, P. J., Kopp, A., Carninci, P., Celniker, S. E., Oliver, B. & Richards, S., 2014, In : Genome Research. 24, 7, p. 1209-1223 15 p.

    Research output: Contribution to journalArticle

    Transcriptome
    Genome
    Drosophila
    Molecular Sequence Annotation
    Genetic Testing
    2013

    Nematodes

    Kiontke, K. & Fitch, D. H. A., Oct 7 2013, In : Current Biology. 23, 19

    Research output: Contribution to journalArticle

    Caenorhabditis elegans
    Cell death
    Green Fluorescent Proteins
    Gene expression
    Genes
    2011

    A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans

    Nelson, M. D., Zhou, E., Kiontke, K., Fradin, H., Maldonado, G., Martin, D., Shah, K. & Fitch, D. H. A., Mar 2011, In : PLoS Genetics. 7, 3, e1002010.

    Research output: Contribution to journalArticle

    morphogenesis
    Caenorhabditis elegans
    RNA Interference
    Morphogenesis
    genome

    A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits

    Kiontke, K. C., Félix, M. A., Ailion, M., Rockman, M. V., Braendle, C., Pénigault, J. B. & Fitch, D. H. A., 2011, In : BMC Evolutionary Biology. 11, 1, 339.

    Research output: Contribution to journalArticle

    Caenorhabditis
    barcoding
    Caenorhabditis elegans
    phylogeny
    fruit

    Overlap extension PCR: an efficient method for transgene construction.

    Nelson, M. D. & Fitch, D. H. A., 2011, In : Methods in Molecular Biology. 772, p. 459-470 12 p.

    Research output: Contribution to journalArticle

    Transgenes
    Polymerase Chain Reaction
    Genes
    Mutation
    Biological Science Disciplines
    2010

    David fitch

    Fitch, D., Oct 26 2010, In : Current Biology. 20, 20

    Research output: Contribution to journalArticle

    Phenotypic plasticity: Different teeth for different feasts

    Kiontke, K. & Fitch, D. H. A., Sep 14 2010, In : Current Biology. 20, 17

    Research output: Contribution to journalArticle

    Genetic Models
    phenotypic plasticity
    Cues
    Plasticity
    Tooth
    2009

    Evolution of early embryogenesis in rhabditid nematodes

    Brauchle, M., Kiontke, K., MacMenamin, P., Fitch, D. H. A. & Piano, F., Nov 1 2009, In : Developmental Biology. 335, 1, p. 253-262 10 p.

    Research output: Contribution to journalArticle

    Embryonic Development
    Embryonic Structures
    Phenotype
    Cell Polarity
    Phylogeny
    2008

    Dropout alignment allows homology recognition and evolutionary analysis of rDNA intergenic spacers

    Ryu, S., Do, Y., Fitch, D. H. A., Kim, W. & Mishra, B., Apr 2008, In : Journal of Molecular Evolution. 66, 4, p. 368-383 16 p.

    Research output: Contribution to journalArticle

    dropouts
    Ribosomal DNA
    intergenic DNA
    homology
    RNA Polymerase I

    Teratorhabditis synpapillata Sudhaus, 1985 (Rhabditida: Rhabditidae) is an associate of the red palm weevil, Rhynchophorus ferrugineus (Coleoptera: Curculionidae)

    Kanzaki, N., Abe, F., Giblin-Davis, R. M., Kiontke, K., Fitch, D. H. A., Hata, K. & Soné, K., Jan 3 2008, In : Nematology. 10, 2, p. 207-218 12 p.

    Research output: Contribution to journalArticle

    Rhabditidae
    Rhynchophorus ferrugineus
    Curculionidae
    nematode
    Phoenix canariensis
    2007

    Caenorhabditis evolution: if they all look alike, you aren't looking hard enough

    Haag, E. S., Chamberlin, H., Coghlan, A., Fitch, D. H. A., Peters, A. D. & Schulenburg, H., Mar 2007, In : Trends in Genetics. 23, 3, p. 101-104 4 p.

    Research output: Contribution to journalArticle

    Caenorhabditis
    Developmental Biology
    Portugal
    Caenorhabditis elegans
    Population Genetics

    Population structure of plasmid-containing strains of Streptococcus mutans, a member of the human indigenous biota

    Caufield, P. W., Saxena, D., Fitch, D. & Li, Y., Feb 2007, In : Journal of Bacteriology. 189, 4, p. 1238-1243 6 p.

    Research output: Contribution to journalArticle

    Biota
    Streptococcus mutans
    Plasmids
    Phylogeny
    Population

    Trends, Stasis, and Drift in the Evolution of Nematode Vulva Development

    Kiontke, K., Barrière, A., Kolotuev, I., Podbilewicz, B., Sommer, R., Fitch, D. H. A. & Félix, M. A., Nov 20 2007, In : Current Biology. 17, 22, p. 1925-1937 13 p.

    Research output: Contribution to journalArticle

    Vulva
    vulva
    Random processes
    Stochastic Processes
    Nematoda
    2006

    Novel gain-of-function alleles demonstrate a role for the heterochronic gene lin-41 in C. elegans male tail tip morphogenesis

    Del Rio-Albrechtsen, T., Kiontke, K., Chiou, S. Y. & Fitch, D. H. A., Sep 1 2006, In : Developmental Biology. 297, 1, p. 74-86 13 p.

    Research output: Contribution to journalArticle

    Morphogenesis
    Alleles
    Genes
    Phenotype
    Mutation
    2005

    Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans

    Maciejowski, J., Ahn, J. H., Cipriani, P. G., Killian, D. J., Chaudhary, A. L., Ji, I. L., Voutev, R., Johnsen, R. C., Baillie, D. L., Gunsalus, K. C., Fitch, D. H. A. & Hubbard, E. J. A., Apr 2005, In : Genetics. 169, 4, p. 1997-2011 15 p.

    Research output: Contribution to journalArticle

    X-Linked Genes
    Caenorhabditis elegans
    Germ Cells
    Genes
    Carisoprodol

    Evolution: An ecological context for C. elegans

    Fitch, D. H. A., Sep 6 2005, In : Current Biology. 15, 17

    Research output: Contribution to journalArticle

    nematode larvae
    Caenorhabditis elegans
    outcrossing
    selfing
    Population

    Introduction to nematode evolution and ecology.

    Fitch, D., 2005, In : WormBook : the online review of C. elegans biology. p. 1-8 8 p.

    Research output: Contribution to journalArticle

    Biological Models
    Nematoda
    Ecology

    The phylogenetic relationships of Caenorhabditis and other rhabditids.

    Kiontke, K. & Fitch, D., 2005, In : WormBook : the online review of C. elegans biology. p. 1-11 11 p.

    Research output: Contribution to journalArticle

    Caenorhabditis
    Tail
    Disorders of Sex Development
    Phylogeny
    Vertebrates
    2004

    Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss

    Kiontke, K., Gavin, N. P., Raynes, Y., Roehrig, C., Piano, F. & Fitcht, D. H. A., Jun 15 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 24, p. 9003-9008 6 p.

    Research output: Contribution to journalArticle

    Caenorhabditis
    Disorders of Sex Development
    Phylogeny
    Introns
    Caenorhabditis elegans
    2003

    Absence of Wolbachia in Nonfilariid Nematodes

    Bordenstein, S. R., Fitch, D. H. A. & Werren, J. H., Sep 2003, In : Journal of Nematology. 35, 3, p. 266-270 5 p.

    Research output: Contribution to journalArticle

    Wolbachia
    Nematoda
    polymerase chain reaction
    arthropods
    Arthropoda

    The genome sequence of Caenorhabditis briggsae: A platform for comparative genomics

    Stein, L. D., Bao, Z., Blasiar, D., Blumenthal, T., Brent, M. R., Chen, N., Chinwalla, A., Clarke, L., Clee, C., Coghlan, A., Coulson, A., D'Eustachio, P., Fitch, D. H. A., Fulton, L. A., Fulton, R. E., Griffiths-Jones, S., Harris, T. W., Hillier, L. W., Kamath, R., Kuwabara, P. E. & 16 others, Mardis, E. R., Marra, M. A., Miner, T. L., Minx, P., Mullikin, J. C., Plumb, R. W., Rogers, J., Schein, J. E., Sohrmann, M., Spieth, J., Stajich, J. E., Wei, C., Willey, D., Wilson, R. K., Durbin, R. & Waterston, R. H., 2003, In : PLoS Biology. 1, 2

    Research output: Contribution to journalArticle

    Caenorhabditis
    Caenorhabditis briggsae
    Caenorhabditis elegans
    Genomics
    Genes
    2002

    One small step for worms, one giant leap for "Bauplan?"

    Fitch, D. H. A. & Sudhaus, W., 2002, In : Evolution and Development. 4, 4, p. 243-246 4 p.

    Research output: Contribution to journalArticle

    Nonvertebrate Chordata
    developmental biology
    Developmental Biology
    Nematoda
    Arthropods

    TLP-1 is an asymmetric cell fate determinant that responds to Wnt signals and controls male tail tip morphogenesis in C. elegans

    Zhao, X., Yang, Y., Fitch, D. & Herman, M. A., 2002, In : Development. 129, 6, p. 1497-1508 12 p.

    Research output: Contribution to journalArticle

    Morphogenesis
    Cell Polarity
    T-Lymphocytes
    Cell Fusion
    Sp Transcription Factors
    2001

    Comparative studies on the phylogeny and systematics of the Rhabditidae (Nematoda)

    Sudhaus, W. & Fitch, D., Mar 2001, In : Journal of Nematology. 33, 1, p. 1-70 70 p.

    Research output: Contribution to journalArticle

    Rhabditidae
    Nematoda
    phylogeny
    2000

    Evolution of "Rhabditidae" and the male tail

    Fitch, D., Sep 2000, In : Journal of Nematology. 32, 3, p. 235-244 10 p.

    Research output: Contribution to journalArticle

    Rhabditidae
    tail
    phylogeny
    Caenorhabditis elegans
    morphogenesis

    Rearrangement of immunoglobulin genes in shark germ cells

    Lee, S. S., Fitch, D., Flajnik, M. F. & Hsu, E., May 15 2000, In : Journal of Experimental Medicine. 191, 10, p. 1637-1647 11 p.

    Research output: Contribution to journalArticle

    Sharks
    Immunoglobulin Genes
    Germ Cells
    Genetic Recombination
    Genes
    1999

    Morphogenesis of the Caenorhabditis elegans male tail tip

    Nguyen, C. Q., Hall, D. H., Yang, Y. & Fitch, D. H. A., Mar 1 1999, In : Developmental Biology. 207, 1, p. 86-106 21 p.

    Research output: Contribution to journalArticle

    Caenorhabditis elegans
    Morphogenesis
    Tail
    Adherens Junctions
    Electron Microscopy
    1997

    Evolution

    Fitch, D. H. A. & Kelley Thomas, W., 1997, C. elegans II. Riddle, D. L., Blumenthal, T., Meyer, B. J. & Priess, J. R. (eds.). Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Evolution of male tail development in rhabditid nematodes related to Caenorhabditis elegans

    Fitch, D. H. A., Mar 1997, In : Systematic Biology. 46, 1, p. 145-179 35 p.

    Research output: Contribution to journalArticle

    Caenorhabditis elegans
    nematode
    Tail
    tail
    Ribosomal DNA
    1995

    18S ribosomal RNA gene phylogeny for some rhabditidae related to Caenorhabditis

    Fitch, D. H. A., Bugaj-Gaweda, B. & Emmons, S. W., 1995, In : Molecular Biology and Evolution. 12, 2, p. 346-358 13 p.

    Research output: Contribution to journalArticle

    Caenorhabditis
    18S Ribosomal RNA
    Rhabditidae
    Phylogeny
    Ribosomal DNA
    Caenorhabditis elegans
    Tail
    Male Genitalia
    Adherens Junctions
    Indirect Fluorescent Antibody Technique
    1994

    Caenorhabditis vulgaris sp.n. (Nematoda: Rhabditidae): A necromenic associate of pill bugs and snails

    Baird, S. E., Fitch, D. & Emmons, S. W., 1994, In : Nematologica. 40, 1-4, p. 1-11 11 p.

    Research output: Contribution to journalArticle

    Caenorhabditis
    Rhabditidae
    Nematoda
    Snails
    snail

    Widespread occurrence of the Tc1 transposon family: Tc1-like transposons from teleost fish

    Radice, A. D., Bugaj, B., Fitch, D. & Emmons, S. W., Nov 1994, In : MGG Molecular & General Genetics. 244, 6, p. 606-612 7 p.

    Research output: Contribution to journalArticle

    Salmo salar
    Oncorhynchus mykiss
    Zebrafish
    Fishes
    Chordata
    1993

    Low codon bias and high rates of synonymous substitution in Drosophila hydei and D. melanogaster histone genes

    Fitch, D. & Strausbaugh, L. D., Mar 1993, In : Molecular Biology and Evolution. 10, 2, p. 397-413 17 p.

    Research output: Contribution to journalArticle

    Drosophila hydei
    histones
    codons
    Codon
    Histones
    1992
    Atelinae
    Globins
    5' Flanking Region
    Haplorhini
    Gene Conversion
    1991

    Duplication of the γ-globin gene mediated by L1 long interspersed repetitive elements in an early ancestor of simian primates

    Fitch, D., Bailey, W. J., Tagle, D. A., Goodman, M., Sieu, L. & Slightom, J. L., 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 16, p. 7396-7400 5 p.

    Research output: Contribution to journalArticle

    Interspersed Repetitive Sequences
    Gene Duplication
    Globins
    Primates
    Genes

    Molecular evolution of the ψη-globin gene locus: Gibbon phylogeny and the hominoid slowdown

    Bailey, W. J., Fitch, D., Tagle, D. A., Czelusniak, J., Slightom, J. L. & Goodman, M., Mar 1991, In : Molecular Biology and Evolution. 8, 2, p. 155-184 30 p.

    Research output: Contribution to journalArticle

    Hylobates
    Hylobatidae
    Globins
    Molecular Evolution
    Hominidae

    Pattern formation in the nematode epidermis: Determination of the arrangement of peripheral sense organs in the C. elegans male tail

    Baird, S. E., Fitch, D., Kassem, I. A. A. & Emmons, S. W., Oct 1991, In : Development. 113, 2, p. 515-526 12 p.

    Research output: Contribution to journalArticle

    Sense Organs
    Epidermis
    Tail
    Sensilla
    Neurons
    Gene Conversion
    Phylogenetics
    Scanning
    Genes
    Gene
    1990

    Molecular history of gene conversions in the primate fetal γ-globin genes: Nucleotide sequences from the common gibbon, Hylobates lar

    Fitch, D., Mainone, C., Goodman, M. & Slightom, J. L., Jan 15 1990, In : Journal of Biological Chemistry. 265, 2, p. 781-793 13 p.

    Research output: Contribution to journalArticle

    Hylobates
    Gene Conversion
    Globins
    Primates
    Nucleotides

    On the origins of tandemly repeated genes: Does histone gene copy number in Drosophila reflect chromosomal location?

    Fitch, D., Strausbaugh, L. D. & Barrett, V., Apr 1990, In : Chromosoma. 99, 2, p. 118-124 7 p.

    Research output: Contribution to journalArticle

    Gene Dosage
    Histones
    Drosophila
    Genes
    Polytene Chromosomes

    Primate evolution at the DNA level and a classification of hominoids

    Goodman, M., Tagle, D. A., Fitch, D., Bailey, W., Czelusniak, J., Koop, B. F., Benson, P. & Slightom, J. L., Mar 1990, In : Journal of Molecular Evolution. 30, 3, p. 260-266 7 p.

    Research output: Contribution to journalArticle

    Hominidae
    primate
    Primates
    taxonomy
    DNA
    1989

    Molecular phylogeny of the family of apes and humans

    Goodman, M., Koop, B. F., Czelusniak, J., Fitch, D., Tagle, D. A. & Slightom, J. L., 1989, In : Genome. 31, 1, p. 316-335 20 p.

    Research output: Contribution to journalArticle

    Hominidae
    Pongidae
    Phylogeny
    phylogeny
    1988

    The spider monkey ψη-globin gene and surrounding sequences: Recent or ancient insertions of LINEs and SINEs?

    Fitch, D., Mainone, C., Sligtom, J. L. & Goodman, M., 1988, In : Genomics. 3, 3, p. 237-255 19 p.

    Research output: Contribution to journalArticle

    Atelinae
    Short Interspersed Nucleotide Elements
    Globins
    Hominidae
    Primates