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Andrew Hamilton

President

    1977 …2019
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    Fingerprint Weighted list of dominant concepts in the researcher's publications (titles and abstracts).

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    Farnesyltranstransferase Medicine & Life Sciences
    Artificial Receptors Chemical Compounds
    Scaffolds Chemical Compounds
    Hydrogen bonds Chemical Compounds
    Prenylation Medicine & Life Sciences
    Peptidomimetics Medicine & Life Sciences
    Molecular recognition Chemical Compounds
    Proteins Chemical Compounds

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    Research Output 1977 2019

    Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors

    Kazi, A., Xiang, S., Yang, H., Chen, L., Kennedy, P., Ayaz, M., Fletcher, S., Cummings, C., Lawrence, H. R., Beato, F., Kang, Y., Kim, M. P., Delitto, A., Underwood, P. W., Fleming, J. B., Trevino, J. G., Hamilton, A. & Sebti, S. M., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5984-5996 13 p.

    Research output: Contribution to journal › Article

    Farnesyltranstransferase
    Transferases
    Pancreatic Neoplasms
    Heterografts
    Prenylation

    Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers

    Meisel, J. W., Hu, C. T. & Hamilton, A., Oct 4 2019, In : Organic Letters. 21, 19, p. 7763-7767 5 p.

    Research output: Contribution to journal › Article

    Open Access
    Functional groups
    Bearings (structural)
    Artificial Receptors
    Molecular recognition
    Solid-Phase Synthesis Techniques

    α-Helix-Mimetic Foldamers for Targeting HIV-1 TAR RNA

    Maity, D., Kumar, S., Curreli, F., Debnath, A. K. & Hamilton, A., Jan 1 2019, In : Chemistry - A European Journal.

    Research output: Contribution to journal › Article

    RNA
    Proteins
    Scaffolds (biology)
    Scaffolds
    Conformations

    Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin

    Lee, C. H., Yu, J. R., Kumar, S., Jin, Y., LeRoy, G., Bhanu, N., Kaneko, S., Garcia, B. A., Hamilton, A. & Reinberg, D., Jan 1 2018, (Accepted/In press) In : Molecular Cell.

    Research output: Contribution to journal › Article

    Chromatin
    Mutation
    Personnel Selection
    Neoplasms
    Clinical Trials

    Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer

    Meisel, J. W., Hu, C. T. & Hamilton, A., Jul 6 2018, In : Organic Letters. 20, 13, p. 3879-3882 4 p.

    Research output: Contribution to journal › Article

    Scaffolds
    Conformations
    Hydrogen
    Hydrogen bonds
    flexibility