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Alan Healy

Assistant Professor of Chemistry

20122019
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Research Output 2012 2019

2019

An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin

Coufalova, D., Remnant, L., Hernychova, L., Muller, P., Healy, A., Kannan, S., Westwood, N., Verma, C. S., Vojtesek, B., Hupp, T. R. & Houston, D. R., May 15 2019, In : Journal of Proteomics. 199, p. 89-101 13 p.

Research output: Contribution to journalArticle

Oligomerization
Protein Subunits
Peptides
Proteins
Oligomers

Structure elucidation of colibactin and its DNA cross-links

Xue, M., Kim, C. S., Healy, A., Wernke, K. M., Wang, Z., Frischling, M. C., Shine, E. E., Wang, W., Herzon, S. B. & Crawford, J. M., Sep 6 2019, In : Science. 365, 6457, aax2685.

Research output: Contribution to journalArticle

DNA
Isotope Labeling
Bacteria
Multigene Family
Tandem Mass Spectrometry

Synthesis and reactivity of precolibactin 886

Healy, A., Wernke, K. M., Kim, C. S., Lees, N. R., Crawford, J. M. & Herzon, S. B., Oct 1 2019, In : Nature chemistry. 11, 10, p. 890-898 9 p.

Research output: Contribution to journalArticle

Metabolites
Pyridones
Cyclization
Biosynthesis
Biomimetics
2018

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., Dec 1 2018, In : Nature Communications. 9, 1, 1107.

Research output: Contribution to journalArticle

dehydrogenases
inhibitors
Tumors
tumors
Cells

Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (Nature Communications (2018) DOI: 10.1038/s41467-018-03441-3)

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., Dec 1 2018, In : Nature Communications. 9, 1, 2071.

Research output: Contribution to journalComment/debate

document markup languages
inhibitors
Publications
Tumors
tumors

Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria

Shine, E. E., Xue, M., Patel, J. R., Healy, A., Surovtseva, Y. V., Herzon, S. B. & Crawford, J. M., Dec 21 2018, In : ACS Chemical Biology. 13, 12, p. 3286-3293 8 p.

Research output: Contribution to journalArticle

Bacteria
Cells
Cell culture
Peptide Synthases
DNA
2017

ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance

Tripathi, P., Shine, E. E., Healy, A., Kim, C. S., Herzon, S. B., Bruner, S. D. & Crawford, J. M., Dec 13 2017, In : Journal of the American Chemical Society. 139, 49, p. 17719-17722 4 p.

Research output: Contribution to journalArticle

Hydrolases
Genes
Bacteria
Biosynthesis
Binding sites

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis

Trautman, E. P., Healy, A., Shine, E. E., Herzon, S. B. & Crawford, J. M., Mar 22 2017, In : Journal of the American Chemical Society. 139, 11, p. 4195-4201 7 p.

Research output: Contribution to journalArticle

Peptide Synthases
Polyketide Synthases
Metabolomics
Biosynthesis
Peptides

Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective

Healy, A. & Herzon, S. B., Oct 25 2017, In : Journal of the American Chemical Society. 139, 42, p. 14817-14824 8 p.

Research output: Contribution to journalReview article

Metabolites
Colorectal Neoplasms
Imines
Mutagens
Cyclization

Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway

Guntaka, N. S., Healy, A., Crawford, J. M., Herzon, S. B. & Bruner, S. D., Oct 20 2017, In : ACS Chemical Biology. 12, 10, p. 2598-2608 11 p.

Research output: Contribution to journalArticle

Functional analysis
Biosynthetic Pathways
Metabolites
Genes
Pyridones
2016

A Mechanistic Model for Colibactin-Induced Genotoxicity

Healy, A., Nikolayevskiy, H., Patel, J. R., Crawford, J. M. & Herzon, S. B., Dec 7 2016, In : Journal of the American Chemical Society. 138, 48, p. 15563-15570 8 p.

Research output: Contribution to journalArticle

DNA
Imines
Pyridones
Escherichia coli
Alkylation

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A

Healy, A., Vizcaino, M. I., Crawford, J. M. & Herzon, S. B., Apr 27 2016, In : Journal of the American Chemical Society. 138, 16, p. 5426-5432 7 p.

Research output: Contribution to journalArticle

Metabolites
Escherichia coli
Polyketides
Double-Stranded DNA Breaks
Asparagine

Selective and efficient generation of ortho-brominated para-substituted phenols in ACS-grade methanol

Georgiev, D., Saes, B. W. H., Johnston, H. J., Boys, S. K., Healy, A. & Hulme, A. N., Jan 1 2016, In : Molecules. 21, 1, 21010088.

Research output: Contribution to journalArticle

Naphthols
Phenols
Halogenation
Phenol
phenols
2015

Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin

Healy, A., Houston, D. R., Remnant, L., Huart, A. S., Brychtova, V., Maslon, M. M., Meers, O., Muller, P., Krejci, A., Blackburn, E. A., Vojtesek, B., Hernychova, L., Walkinshaw, M. D., Westwood, N. J. & Hupp, T. R., May 1 2015, In : Chemical Science. 6, 5, p. 3109-3116 8 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Ligands
Proteins
Tumor Suppressor Protein p53
Oligomerization

Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis

Healy, A., Izumikawa, M., Slawin, A. M. Z., Shin-Ya, K. & Westwood, N. J., Mar 23 2015, In : Angewandte Chemie - International Edition. 54, 13, p. 4046-4050 5 p.

Research output: Contribution to journalArticle

Proteins
Stereochemistry
Acids
Proteasome Endopeptidase Complex
Bioactivity

Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction

Healy, A. & Westwood, N. J., Jan 1 2015, In : Organic and Biomolecular Chemistry. 13, 42, p. 10527-10531 5 p.

Research output: Contribution to journalArticle

Diels-Alder reactions
Cycloaddition Reaction
activity (biology)
Biological Products
pyruvates

Total synthesis and biological evaluation of the tetramic acid based natural product harzianic acid and its stereoisomers

Healy, A., Vinale, F., Lorito, M. & Westwood, N. J., Feb 6 2015, In : Organic Letters. 17, 3, p. 692-695 4 p.

Research output: Contribution to journalArticle

Stereoisomerism
Biological Products
activity (biology)
Isomers
acids
2012

Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes

Taladriz, A., Healy, A., Flores Pérez, E. J., Herrero García, V., Ríos Martínez, C., Alkhaldi, A. A. M., Eze, A. A., Kaiser, M., De Koning, H. P., Chana, A. & Dardonville, C., Mar 22 2012, In : Journal of Medicinal Chemistry. 55, 6, p. 2606-2622 17 p.

Research output: Contribution to journalArticle

Pentamidine
Trypanosomiasis
Salts
Trypanosoma brucei brucei
Pharmaceutical Preparations