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Alan Healy

Assistant Professor of Chemistry

    20122019
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    Fingerprint Weighted list of dominant concepts in the researcher's publications (titles and abstracts).

    Metabolites Chemical Compounds
    Biological Products Chemical Compounds
    Biosynthesis Chemical Compounds
    Cells Chemical Compounds
    Genes Engineering & Materials Science
    Escherichia coli Engineering & Materials Science
    Tumors Chemical Compounds
    Peptide Synthases Chemical Compounds

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    Research Output 2012 2019

    Addendum: Synthesis and reactivity of precolibactin 886

    Healy, A. R., Wernke, K. M., Kim, C. S., Lees, N. R., Crawford, J. M. & Herzon, S. B., Dec 1 2019, In : Nature chemistry. 11, 12, 1 p.

    Research output: Contribution to journalArticle

    Open Access

    An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin

    Coufalova, D., Remnant, L., Hernychova, L., Muller, P., Healy, A., Kannan, S., Westwood, N., Verma, C. S., Vojtesek, B., Hupp, T. R. & Houston, D. R., May 15 2019, In : Journal of Proteomics. 199, p. 89-101 13 p.

    Research output: Contribution to journalArticle

    Oligomerization
    Protein Subunits
    Peptides
    Proteins
    Oligomers

    Structure elucidation of colibactin and its DNA cross-links

    Xue, M., Kim, C. S., Healy, A., Wernke, K. M., Wang, Z., Frischling, M. C., Shine, E. E., Wang, W., Herzon, S. B. & Crawford, J. M., Sep 6 2019, In : Science. 365, 6457, aax2685.

    Research output: Contribution to journalArticle

    DNA
    Isotope Labeling
    Bacteria
    Multigene Family
    Tandem Mass Spectrometry

    Synthesis and reactivity of precolibactin 886

    Healy, A., Wernke, K. M., Kim, C. S., Lees, N. R., Crawford, J. M. & Herzon, S. B., Oct 1 2019, In : Nature chemistry. 11, 10, p. 890-898 9 p.

    Research output: Contribution to journalArticle

    Metabolites
    Pyridones
    Cyclization
    Biosynthesis
    Biomimetics

    A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

    Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., Dec 1 2018, In : Nature Communications. 9, 1, 1107.

    Research output: Contribution to journalArticle

    dehydrogenases
    inhibitors
    Tumors
    tumors
    Cells