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Alan Healy

Assistant Professor of Chemistry

20122019
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Fingerprint Weighted list of dominant concepts in the researcher's publications (titles and abstracts).

Biological Products Chemical Compounds
Metabolites Chemical Compounds
Cells Chemical Compounds
Biosynthesis Chemical Compounds
Tumors Chemical Compounds
Genes Engineering & Materials Science
Escherichia coli Engineering & Materials Science
Peptide Synthases Chemical Compounds

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Research Output 2012 2019

An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin

Coufalova, D., Remnant, L., Hernychova, L., Muller, P., Healy, A., Kannan, S., Westwood, N., Verma, C. S., Vojtesek, B., Hupp, T. R. & Houston, D. R., May 15 2019, In : Journal of Proteomics. 199, p. 89-101 13 p.

Research output: Contribution to journalArticle

Oligomerization
Protein Subunits
Peptides
Proteins
Oligomers

Structure elucidation of colibactin and its DNA cross-links

Xue, M., Kim, C. S., Healy, A., Wernke, K. M., Wang, Z., Frischling, M. C., Shine, E. E., Wang, W., Herzon, S. B. & Crawford, J. M., Sep 6 2019, In : Science. 365, 6457, aax2685.

Research output: Contribution to journalArticle

DNA
Isotope Labeling
Bacteria
Multigene Family
Tandem Mass Spectrometry

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., Dec 1 2018, In : Nature Communications. 9, 1, 1107.

Research output: Contribution to journalArticle

dehydrogenases
inhibitors
Tumors
tumors
Cells

Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (Nature Communications (2018) DOI: 10.1038/s41467-018-03441-3)

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., Dec 1 2018, In : Nature Communications. 9, 1, 2071.

Research output: Contribution to journalComment/debate

document markup languages
inhibitors
Publications
Tumors
tumors

Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria

Shine, E. E., Xue, M., Patel, J. R., Healy, A., Surovtseva, Y. V., Herzon, S. B. & Crawford, J. M., Dec 21 2018, In : ACS Chemical Biology. 13, 12, p. 3286-3293 8 p.

Research output: Contribution to journalArticle

Bacteria
Cells
Cell culture
Peptide Synthases
DNA