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Alan Healy

Assistant Professor of Chemistry

20122019
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Fingerprint Weighted list of dominant concepts in the researcher's publications (titles and abstracts).

Metabolites Chemical Compounds
Biological Products Chemical Compounds
Biosynthesis Chemical Compounds
Cells Chemical Compounds
Genes Engineering & Materials Science
Escherichia coli Engineering & Materials Science
Tumors Chemical Compounds
Peptide Synthases Chemical Compounds

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Research Output 2012 2019

An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin

Coufalova, D., Remnant, L., Hernychova, L., Muller, P., Healy, A., Kannan, S., Westwood, N., Verma, C. S., Vojtesek, B., Hupp, T. R. & Houston, D. R., May 15 2019, In : Journal of Proteomics. 199, p. 89-101 13 p.

Research output: Contribution to journalArticle

Oligomerization
Protein Subunits
Peptides
Proteins
Oligomers

Structure elucidation of colibactin and its DNA cross-links

Xue, M., Kim, C. S., Healy, A., Wernke, K. M., Wang, Z., Frischling, M. C., Shine, E. E., Wang, W., Herzon, S. B. & Crawford, J. M., Sep 6 2019, In : Science. 365, 6457, aax2685.

Research output: Contribution to journalArticle

DNA
Isotope Labeling
Bacteria
Multigene Family
Tandem Mass Spectrometry

Synthesis and reactivity of precolibactin 886

Healy, A., Wernke, K. M., Kim, C. S., Lees, N. R., Crawford, J. M. & Herzon, S. B., Oct 1 2019, In : Nature chemistry. 11, 10, p. 890-898 9 p.

Research output: Contribution to journalArticle

Metabolites
Pyridones
Cyclization
Biosynthesis
Biomimetics

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., Dec 1 2018, In : Nature Communications. 9, 1, 1107.

Research output: Contribution to journalArticle

dehydrogenases
inhibitors
Tumors
tumors
Cells

Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (Nature Communications (2018) DOI: 10.1038/s41467-018-03441-3)

Ladds, M. J. G. W., Van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A. L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., Dec 1 2018, In : Nature Communications. 9, 1, 2071.

Research output: Contribution to journalComment/debate

document markup languages
inhibitors
Publications
Tumors
tumors